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最後更新2019/11/13
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友善列印

我們的副教務長

 

林芸薇 副教務長

國立嘉義大學生化科技系

教授兼副教務長

聯絡電話:271-7770

E-maillinyw@mail.ncyu.edu.tw

學歷

國立清華大學生命科學系博士

研究領域

分子腫瘤學;分子生物學;訊號傳遞;基因與細胞毒理;核酸修補

期刊論文

1.Ko JC, Chen JC, Yen TC, Chen TY, Ma PF, Lin YC, Cheng HH, Taso YC Taso, and Lin YW*. Nitroglycerin enhances cisplatin-induced cytotoxicity via AKT inactivation and thymidylate synthase down-regulation in human lung cancer cells. Pharmacology 2019 Oct 18:1-16. doi: 10.1159/000503688. [SCI]

2.Chen JC, Ko JC, Yen TC, Chen TY, Lin YC, Ma PF, and Lin YW*. Capsaicin enhances erlotinib-induced cytotoxicity via AKT inactivation and excision repair cross-complementary 1 (ERCC1) down-regulation in human lung cancer cells. Toxicology Research 2019 Mar; 8: 459–470. [SCI]

3.Ko JC, Chen JC, Chen TY, Yen TC, Ma PF, Lin YC, Wu CH, Peng YS, Zheng HY, Lin YW*. Inhibition of thymidine phosphorylase expression by Hsp90 inhibitor potentiates the cytotoxic effect of salinomycin in human non-small-cell lung cancer cells. Toxicology 2019 Feb 20;417:54-63.

4.Chen JC, Ma PF, Lin YC, Wu CH, Peng YS, Zheng HY, Lin MC, ·Li YT, Lin YW*. 17-(Allylamino)-17-Demethoxygeldanamycin Enhances Etoposide-Induced Cytotoxicity via the Downregulation of Xeroderma Pigmentosum Complementation Group C Expression in Human Lung Squamous Cell Carcinoma Cells. Pharmacology 2018 Jun 28;102(1-2):91-104.

5.Chen JC, Wu CH, Peng YS, Zheng HY, Lin YC, Ma PF, Yen TC, Chen TY, Lin YW*. Astaxanthin enhances erlotinib-induced cytotoxicity by p38 MAPK mediated xeroderma pigmentosum complementation group C (XPC) down-regulation in human lung cancer cells. Toxicology Research 2018 Sep19; 7(6): 1247–1256.

6.Hsieh C, Lin YW, Chen CH, Ku W, Ma F, Yu H, Chu C. Yellow and green pigments from Calophyllum inophyllum L. seed oil induce cell death in colon and lung cancer cells. Oncology Letters 2018 Apr;15(4):5915-5923. [SCI]

7.Tung CL, Chen JC, Wu CH, Peng YS, Chen WC, Zheng HY, Jian YJ, Wei CL, Cheng YT, and Lin YW*. Salinomycin acts through reducing AKT-dependent thymidylate synthase expression to enhance erlotinib-induced cytotoxicity in human lung cancer cells. Exp Cell Res 2017 Aug 1;357(1):59-66. [SCI]

8.Liao KS, Wei CL, Chen JC, Zheng HY, Chen WC, Wu CH, Wang TJ, Peng YS, Chang PY, and Lin YW*. Astaxanthin enhances pemetrexed-induced cytotoxicity by downregulation of thymidylate synthase expression in human lung cancer cells. Regulatory Toxicology and Pharmacology 2016 Sep. 28; 81:353-361. [SCI]

9.Ko JC, Zheng HY, Chen WC, Peng YS, Wu CH, CL Wei, JC Chen, and Lin YW*. Salinomycin enhances cisplatin-induced cytotoxicity in human lung cancer cells via down-regulation of AKT-dependent thymidylate synthase expression. Biochemical Pharmacology 2016 Dec. 15; 122:90-98 [SCI]

10.Tung CL, Jian YJ, Chen JC, Wang TJ, Chen WC, Zheng HY, Chang PY, Liao KS, and Lin YW*. Curcumin downregulates p38 MAPK–dependent X-ray repair cross-complement group 1 (XRCC1) expression to enhance cisplatin-induced cytotoxicity in human lung cancer cells. Naunyn-Schmiedeberg's Archives of Pharmacology 2016 Jun;389(6):657-66. [SCI]

11.Ko JC, Chen JC, Wang TJ, Zheng HY, Chen WC, Chang PY, and Lin YW*. Astaxanthin down-regulates Rad51 expression via inactivation of AKT kinase to enhance mitomycin C-induced cytotoxicity in human non-small cell lung cancer cells. Biochemical Pharmacology 2016 April 1; 105:91-100. [SCI]

12.Ko JC, Wang TJ, Chang PY, Syu JJ, Chen JC, Chen CY, Jian YT, Jian YJ, Zheng HY, Chen WC, and Lin YW*. Minocycline enhances mitomycin C-induced cytotoxicity through down-regulating ERK1/2-mediated Rad51 expression in human non-small cell lung cancer cells. Biochemical Pharmacology 2015 Oct 1; 97(3):331-340. [SCI]

13.Ko JC, Syu JJ, Chen JC, Wang TJ, Chang PY, Chen CY, Jian YT, Jian YJ, and Lin YW*. Resveratrol enhances etoposide-induced cytotoxicity through down-regulating ERK1/2 and AKT-mediated X-ray repair cross-complement group 1 (XRCC1) protein expression in human non-small-cell lung cancer cells. Basic & Clinical Pharmacology & Toxicology 2015 Dec; 117(6):383-391. [SCI]

14.Kuo CH, Lin YW, Chen RS. Lipopeptides extract from Bacillus amyloliquefaciens induce human oral squamous cancer cell death. Asian Pacific Journal of Cancer Prevention 2015; 16(1):91-6.

15.Tung CL, Jian YJ, Syu JJ, Wang TJ, Chang PY, Chen CY, Jian YT, and Lin YW*. Down-regulation of ERK1/2 and AKT-mediated X-ray repair cross-complement group 1 protein (XRCC1) expression by Hsp90 inhibition enhances the gefitinib-induced cytotoxicity in human lung cancer cells. Exp Cell Res 2015 May 15; 334(1):126-135. [SCI]

16.Ko JC, Chiu HC, Syu JJ, Chen CY, Jian YJ, Huang YJ, Wo TY, Jian YJ, Chang PY, Wang TJ, and Lin YW*. Down-regulation of MSH2 expression by Hsp90 inhibition enhances cytotoxicity affected by tamoxifen in human lung cancer cells. Biochemical and Biophysical Research Communications 2015 Jan 2; 456(1):506-512. [SCI]

17.Ko JC, Chiu HC, Syu JJ, Jian YJ, Chen CY, Jian YT, Huang YJ, Wo TY, Lin YW*. Tamoxifen enhances erlotinib-induced cytotoxicity through down-regulating AKT-mediated thymidine phosphorylase expression in human non-small-cell lung cancer cells. Biochemical Pharmacology 2014 Mar 1; 88(1):119-127. [SCI]

18.Tung CL, Chiu HC, Jian YJ, Jian YT, Chen CY, Syu JJ, Wo TY, Huang YJ, Tseng SC, and Lin YW*. Down-regulation of MSH2 expression by an Hsp90 inhibitor enhances pemetrexed-induced cytotoxicity in human non-small-cell lung cancer cells. Exp Cell Res 2014 Apr 1;322(2):345-354. [SCI]

19.Ko JC, Chiu HC, Wo TY, Huang YJ, Tseng SC, Huang YC, Chen HJ, Syu JJ, Chen CY, Jian YT, Jian YJ, Lin YW*. Inhibition of p38 MAPK-dependent MutS homologue-2 (MSH2) expression by metformin enhances gefitinib-induced cytotoxicity in human squamous lung cancer cells. Lung Cancer 2013 Dec; 82(3):397-406. [SCI]

20.Chen RS, Ko JC, Chiu HC, Wo TY, Huang YJ, Tseng SC, Chen HJ, Huang YC, Jian YJ, Lee WT, Lin YW*. Pemetrexed downregulates ERCC1 expression and enhances cytotoxicity effected by resveratrol in human nonsmall cell lung cancer cells. Naunyn-Schmiedeberg's Archives of Pharmacology 2013 Dec; 386(12): 1047-1059. [SCI]

21.Ko JC, Huang YC, Chen HJ, Tseng SC, Chiu HC, Wo TY, Huang YJ, Weng SH, Chiou RY, Lin YW*. Metformin induces cytotoxicity by down-regulating thymidine phosphorylase and excision repair cross-complementation 1 expression in non-small cell lung cancer cells. Basic & Clinical Pharmacology & Toxicology 2013 Jul; 113(1):56-65. [SCI]

22.Tseng SC, Huang YC, Chen HJ, Chiu HC, Huang YJ, Wo TY, Weng SH, Lin YW*. Metformin-mediated downregulation of p38 mitogen-activated protein kinase-dependent excision repair cross-complementing 1 decreases DNA repair capacity and sensitizes human lung cancer cells to paclitaxel. Biochemical Pharmacology 2013 Feb 15; 85(4):583-594. [SCI]

23.Ko JC, Chen HJ, Huang YC, Tseng SC, Weng SH, Wo TY, Huang YJ, Chiu HC, Tsai MS, Chiou RY, Lin YW*. HSP90 inhibition induces cytotoxicity via down-regulation of Rad51 expression and DNA repair capacity in non-small cell lung cancer cells. Regulatory Toxicology and Pharmacology 2012 Dec ;64(3): 415-424. [SCI]

24.Lu CH, Lin SC, Yang SY, Pan MY, Lin YW, Hsu CY, Wei YH, Chang JS, Chang CC*. Prodigiosin-induced cytotoxicity involves RAD51 down-regulation through the JNK and p38 MAPK pathways in human breast carcinoma cell lines. Toxicol Lett. 2012 Jul 7; 212(1):83-89. [SCI]

25.Weng SH, Tseng SC, Huang YC, Chen HJ, Lin YW*. Inhibition of thymidine phosphorylase expression by using an HSP90 inhibitor potentiates the cytotoxic effect of cisplatin in non-small-cell lung cancer cells. Biochemical Pharmacology 2012 Jul 1; 84(1):126-136. [SCI]

26.Tsai MS, Weng SH, Chen HJ, Chiu YF, Huang YC, Tseng SC, Kuo YH, Lin YW*. Inhibition of p38 MAPK–dependent excision repair cross-complementing 1 expression decreases the DNA repair capacity to sensitize lung cancer cells to etoposide. Molecular Cancer Therapeutics 2012 Mar; 11(3):561-571. [SCI]

27.Weng SH, Tsai MS, Chiu YF, Kuo YH, Chen HJ, Lin YW*. Enhancement of mitomycin C-induced cytotoxicity by curcumin results from down-regulation of MKK1/2-ERK1/2-mediated thymidine phosphorylase expression. Basic & Clinical Pharmacology & Toxicology 2012 Mar; 110(3):298-306. [SCI]

28.Ko JC, Tsai MS, Weng SH, Kuo YH, Chiu YF, Lin YW*. Curcumin enhances the mitomycin C-induced cytotoxicity via downregulation of MKK1/2-ERK1/2-mediated Rad51 expression in non-small cell lung cancer cells. Toxicology and Applied Pharmacology 2011 Sep 15;255(3):327-38. [SCI]

29.Shen YH, Chen BR, Cherng SH, Chueh PJ, Tan X, Lin YW, Lin JC, Chuang SM*. Cisplatin transiently up-regulates hHR23 expression through enhanced translational efficiency in A549 adenocarcinoma cells. Toxicol Lett. 2011 Sep 10; 205(3):341-350. [SCI]

30.Tsai MS, Weng SH, Kuo YH, Chiu YF, Lin YW*. Synergistic effect of curcumin and cisplatin via downregulation of thymidine phosphorylase and excision repair cross-complementary 1 (ERCC1). Molecular Pharmacology 2011 Jul; 80(1):136-146. [SCI]

31.Ko JC, Tsai MS, Chiu YF, Weng SH, Kuo YH, Lin YW*. Up-regulation of extracellular signal-regulated kinases 1/2-dependent thymidylate synthase and thymidine phosphorylase contributes to cisplatin resistance in human non-small- cell lung cancer cells. Journal of Pharmacology and Experimental Therapeutics 2011 Jul; 338(1):184-194. [SCI]

32.Ko JC, Tsai MS, Kuo YH, Chiu YF, Weng SH, Su YC, Lin YW*. Modulation of Rad51, ERCC1, and thymidine phosphorylase by emodin result in synergistic cytotoxic effect in combination with capecitabine. Biochemical Pharmacology 2011 Mar 1; 81(5):680-690. [SCI]

33.Tsai MS, Kuo YH, Chiu YF, Su YC, Lin YW*. Down-regulation of Rad51 expression overcomes drug resistance to gemcitabine in human non-small-cell lung cancer cells. Journal of Pharmacology and Experimental Therapeutics 2010 Dec; 335(3):830-840. [SCI]

34.Su YJ, Tsai MS, Kuo YH, Chiu YF, Cheng CM, Lin ST, Lin YW*. Role of Rad51 Down-Regulation and Extracellular Signal-Regulated Kinases 1 and 2 Inactivation in Emodin and Mitomycin C-Induced Synergistic Cytotoxicity in Human Non-Small-Cell Lung Cancer Cells. Molecular Pharmacology 2010 Apr; 77(4):633-643. [SCI]

35.Ko JC, Su YJ, Lin ST, Jhan JY, Ciou SC, Cheng CM, Lin YW*. Suppression of ERCC1 and Rad51 expression through ERK1/2 inactivation is essential in emodin-mediated cytotoxicity in human non-small cell lung cancer cells. Biochemical Pharmacology 2010 Feb 15; 79(4):655-664. [SCI]

36.Lin YW, Yang FJ, Chen CL, Lee WT, Chen RS*. Free radical scavenging activity and antiproliferative potential of Polygonum cuspidatum root extracts. Journal of Natural Medicines 2010 Apr; 64(2):146-152. [SCI]

37.Ko JC, Su YJ, Lin ST , Jhan JY, Ciou SC, Cheng CM, Chiu YF, Kuo YH, Tsai MS, Lin YW*. Emodin enhances cisplatin-induced cytotoxicity via down-regulation of ERCC1 and inactivation of ERK1/2. Lung Cancer 2010 Aug; 69(2):155-164. [SCI]

38.Ko JC, Ciou SC, Jhan JY, Cheng CM, Su YJ, Chuang SM, Lin ST, Chang CC, Lin YW*. Roles of MKK1/2-ERK1/2 and PI3K-AKT signaling pathways in erlotinib-induced Rad51 suppression and cytotoxicity in human non-small cell lung cancer cells. Molecular Cancer Research 2009 Aug; 7(8):1378-89. [SCI]

39.Chen RS, Jhan JY, Su YJ, Lee WT, Cheng CM, Ciou SC, Lin ST, Chuang SM, Ko JC, Lin YW*. Emodin enhances gefitinib-induced cytotoxicity via Rad51 downregulation and ERK1/2 inactivation. Exp Cell Res 2009 Sep 10; 315(15):2658-2672. [SCI]

40.Ko JC, Wang LH, Jhan JY, Ciou SC, Hong JH, Lin ST, Lin YW*. The role of celecoxib in Rad51 expression and cell survival affected by gefitinib in human non-small cell lung cancer cells. Lung Cancer 2009 Sep 10; 65(3):290-298. [SCI]

41.Huang S, Chueh PJ, Lin YW, Shih TS, Chuang SM*. Disturbed mitotic progression and genome segregation are involved in cell transformation mediated by nano-TiO2 long-term exposure. Toxicol Appl Pharmacol 2009 Dec 1; 241(2):182-94. [SCI]

42.Li JP, Wang CY, Tang YA, Lin YW, Yang JL*. Role of extracellular signal-regulated kinase (ERK) signaling in nucleotide excision repair and genotoxicity in response to As(III) and Pb(II). Pure Appl. Chem. 2008;80 (12):2735-2750. [SCI]

43.Ko JC, Hong JH, Wang LH, Cheng CM, Ciou SC, Lin ST, Jheng MY, Lin YW*. Role of repair protein Rad51 in regulating the response to gefitinib in human non-small cell lung cancer cells. Molecular Cancer Therapeutics 2008 Nov; 7(11):3632-41. [SCI]

44.Ko JC, Ciou SC, Cheng CM, Wang LH, Hong JH, Jheng MY, Ling ST, Lin YW*. Involvement of Rad51 in cytotoxicity induced by epidermal growth factor receptor inhibitor (gefitinib, IressaR) and chemotherapeutic agents in human lung cancer cells. Carcinogenesis 2008 Jul; 29(7):1448-58. [SCI]

45.Wang CY, Lin YW, Yang JL*. Activation of protein kinase Calpha signaling prevents cytotoxicity and mutagenicity following lead acetate in CL3 human lung cancer cells. Toxicology 2008 Aug 19; 250(1):55-61. [SCI]

46.Chuang SM, Wang LH, Hong JH, Lin YW*. Induction of Rad51 protein levels by p38 MAPK decreases cytotoxicity and mutagenicity in benzo[a]pyrene-exposed human lung cancer cells. Toxicol Appl Pharmacol 2008 Aug 1; 230(3):290-7. [SCI]

47.Ko JC, Hong JH, Wang LH, Lin YW*. The role of repair protein Rad51 in synergistic cytotoxicity and mutagenicity induced by epidermal growth factor receptor inhibitor (Gefitinib, IressaR) and benzo[a]pyrene in human lung cancer. Exp Cell Res 2008 May 1; 314(8):1881-91. [SCI]

48.Lin YW, Yang JL*. Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling. J Biol Chem 2006 Jan 13; 281(2):915-26. [SCI]

49.Lin YW, Chuang SM, Yang JL*. ERK1/2 achieves sustained activation by stimulating MAPK phosphatase-1 degradation via the ubiquitin-proteasome pathway. J Biol Chem 2003 Jun 13; 278(24):21534-41. [SCI]

50.Lin YW, Chuang SM, Yang JL*. Persistent activation of ERK1/2 by lead acetate increases nucleotide excision repair synthesis and confers anti-cytotoxicity and anti-mutagenicity. Carcinogenesis 2003 Jan; 24(1):53-61. [SCI]

 

會議論文

1.Lin, Y.-W., and Yang, J.-L. (2001) Activation of ERK by lead acetate confers anti-cytotoxixity and anti-mutagenicity in cultured human cells. 8th International Conference on Environmental Mutagens. Abstract No. P6-12. Shizuoka, Japan, October 21 – 26.

2.Yang, J.-L., Liou, G.-Y., Lin, Y.-W., Chuang, S.-M., and Chen, R.-H. (2001) Roles of three mitogen-activated protein kinase in UV-induced mutagenesis. 8th International Conference on Environmental Mutagens. Abstract No. P3-6. Shizuoka, Japan, October 21 – 26.

3.Yun-Wei Lin and Jai-Ling Yang. (2005) Proteolysis of Dual-Specificity MAPK Phosphatase MKP-1/CL100/DUSP1 via ERK Phosphorylation and SCFSkp2 Ubiquitination. FASEB Summer Research Conferences. Abstract No. 28. Snowmass, Colorado, July 16 – 21.

4.Lyu-Han Wang, Jhao-Hao Hong, and Yun-Wei Lin. (2007) p38 MAPK activation by benzo[a]pyrene increase Rad51 protein level and prevent cytotoxicity and mutagenicity in human lung cancer cells. The 1st International Cancer Symposium. Abstract No. 1-10. China Medical University and Hospital, Taiwan, November 16 – 17.

5.Jen-Chung Ko, Jhao-Hao Hong, Lyu-Han Wang and Yun-Wei Lin. (2008) The role of repair protein Rad51 in synergistic cytotoxicity and mutagenicity induced by epidermal growth factor receptor inhibitor (Gefitinib, IressaR) and benzo[a]pyrene in human lung cancer. American Association for Cancer Research Annual Meeting. Abstract No. 590. San Diego Convention Center, San Diego, CA. April 12 – 16.

6.Show-Mei Chuang, Lyu-Han Wang, Jhao-Hao Hong, and Yun-Wei Lin. (2008) Induction of Rad51 protein levels by p38 MAPK decreases cytotoxicity and mutagenicity in benzo[a]pyrene-exposed human lung cancer cells. American Association for Cancer Research Annual Meeting. Abstract No. 4372. San Diego Convention Center, San Diego, CA. April 12 – 16.

7.Jhao-Hao Hong and Yun-Wei Lin. (2008) The Role of Rad51 in Benzo[a]pyrene and Epidermal Growth Factor Receptor Inhibitor (Gefitinib, Iressa) Induced Synergistic Cytotoxicity in Human Lung Cancer. Abstract No. P144. The 23rd Joint Annual Conference of Biomedical Science (2008). National Defence Medical Center, Taiwan. March 29 – 30.

8.Lyu-Han Wang and Yun-Wei Lin. (2008) The Role of p38 MAPK and ATM/ATR Signal in Benzo[a]pyrene Induced Rad51 Gene and Protein Expression in Human Lung Cancer Cells. Abstract No. P568. The 23rd Joint Annual Conference of Biomedical Science (2008). National Defence Medical Center, Taiwan. March 29 – 30.

9.Jen-Chung Ko, Chao-Min Cheng, Shih-Ci Ciou, Jhih-Yuan Jhan, Ying-Jhen Su, Show-Mei Chuang, Szu-Ting Lin and Yun-Wei Lin. (2009) Role of MKK1/2-ERK1/2 and PI3K-AKT signaling in erlotinib decrease Rad51 expression and cell survival in human non-small cell lung cancer cells. Abstract No. 5046. American Association for Cancer Research Annual Meeting. Colorado Convention Center, Denver, CO. April 18 – 22.

10.Jhih-Yuan Jhan , Lyu-Han Wang, Shih-Ci Ciou and Yun-Wei Lin. (2009) Role of Celecoxib in Rad51 Expression and Cell Survival Affected by Gefitinib in Human Non-Small Cell Lung Cancer Cells. Abstract No. P788. The 24th Joint Annual Conference of Biomedical Science (2009). National Defense Medical Center, Taiwan. March 21 – 22.

11.Chao-Min Cheng, Shih-Ci Ciou, Yun-Wei Lin. (2009) Rad51 Regulate the Different Response to Gefitinib in Human Non-Small Cell Lung Cancer Cells. Abstract No. P716. The 24th Joint Annual Conference of Biomedical Science (2009). National Defense Medical Center, Taiwan. March 21 – 22.

12.Shih-Ci Ciou, Chao-Min Cheng, Yun-Wei Lin. (2009) Involvement of Rad51 in Cytotoxicity induced by Gefitinib and Chemotherapeutic agents in Human Lung Cancer Cells. Abstract No. P583. The 24th Joint Annual Conference of Biomedical Science (2009). National Defense Medical Center, Taiwan. March 21 – 22.

13.Min-Shao Tsai, Ying-Jhen Su, Szu-Ting Lin, Yu-Fan Chiu, Ya-Hsun Kuo, Yun-Wei Lin. (2009) Emodin enhances cisplatin-induced cytotoxicity via down-regulation of ercc1 and inactivation of erk1/2 in human non-small cell lung cancer cells. Abstract No. PP-21. Biotechnology Taiwan 2009 Conference. Chang Yung-Fa Foundation International Convention Center, Taipei, Taiwan. November 68.

14.Ying-Jhen Su, Szu-Ting Lin, Yun-Wei Lin. (2009) Suppression of ercc1 and rad51 expression through erk1/2 inactivation is essential in emodin-mediated cytotoxicity in human lung cancer cells. Abstract No. PP-22. Biotechnology Taiwan 2009 Conference. Chang Yung-Fa Foundation International Convention Center, Taipei, Taiwan. November 68.

15.Yun-Wei Lin, Jen-Chung Ko, Ying-Jhen Su. (2009) Roles of MKK1/2-ERK1/2 and PI3K-AKT signaling pathways in erlotinib-induced Rad51 suppression and cytotoxicity in human non-small cell lung cancer cells. Abstract No. PP-23. Biotechnology Taiwan 2009 Conference. Chang Yung-Fa Foundation International Convention Center, Taipei, Taiwan. November 68.

16.Su YJ, Tsai MS, Kuo YH, Chiu YF, Cheng CM, Lin ST, Lin YW. (2010) Role of Rad51 downregulation and ERK1/2 inactivation in emodin and mitomycin C-induced synergistic cytotoxicity in human non-small cell lung cancer cells. Abstract No. A19. AACR/JCA Joint Conference: Cancer Genomics, Epigenomics, and the Development of Novel Therapeutics. Hilton Waikoloa Village, Waikoloa, Hawaii. February 59.

17.Min-Shao Tsai, Yu-Fan Chiu, Shao-Hsing Weng, Ya-Hsun Kuo, and Yun-Wei Lin. (2011) Thymidylate synthase and thymidine phosphorylase expression contributes to cisplatin resistance. Abstract No. 1699. Session ID: Experimental and Molecular Therapeutics 12. 102nd AACR Annual Meeting. Orange Country Convention Center, Orlando, Florida. April 26.

18.Shao-Hsing Weng, Min-Shao Tsai, Yu-Fan Chiu, Ya-Hsun Kuo, and Yun-Wei Lin. (2011) Curcumin sensitizes non-small cell lung cancer cells to cisplatin induced cytotoxicity via thymidine phosphorylase and ERCC1 downregulation. Abstract No. P123. The 26th Joint Annual Conference of Biomedical Sciences, National Defense Medical Center, Taiwan. March 26 – 27.

19.Min-Shao Tsai, Ya-Hsun Kuo, Yu-Fan Chiu, Shao-Hsing Weng, and Yun-Wei Lin. (2011) Inhibition of Rad51 and ERCC1 and increase of thymidine phosphorylase by emodin enhance capecitabine-induced cytotoxicity in human non-small cell lung cancer cells. Abstract No. O24. The 26th Joint Annual Conference of Biomedical Sciences, National Defense Medical Center, Taiwan. March 26 – 27.

20.Min-Shao Tsai, Ya-Hsun Kuo, Yu-Fan Chiu, Ying-Chen Su, and Yun-Wei Lin. (2011) Downregulation of Rad51 expression overcomes drug resistance to gemcitabine in human non-small cell lung cancer cells. Abstract No. 22. Physiology Symposium 2011. International Conference Hall, Lan-tan Campus, National Chia-Yi University. April 1 – 2.

21.Yu-Fan Chiu, Min-Shao Tsai, Shao-Hsing Weng, Ya-Hsun Kuo, Yun-Wei Lin. (2011) Up-regulation of ERK1/2-dependent thymidylate synthase and thymidine phosphorylase contributes to cisplatin resistance in human non-small cell lung cancer cells. Abstract No. 24. Physiology Symposium 2011. International Conference Hall, Lan-tan Campus, National Chia-Yi University. April 1 – 2.

22.Yun-Wei Lin, Shao-Hsing Weng, Jen-Chung Ko, Huang-Jen Chen, Sheng-Chieh Tseng, Yu-Ching Huang, Min-Shao Tsai, Robin Y.-Y. Chiou. (2012) HSP90 inhibition induced cytotoxicity via downregulation of Rad51 expression and DNA repair capacity in non-small cell lung cancer cells. Abstract No. 2554. Session ID: Carcinogensis 2: DNA damage Repair and Signal Transduction. AACR Annual Meeting 2012. McCormik Place West, Chicago, IL. March 31April 4.

23.Yu-Ching Huang, Sheng-Chieh Tseng, Huang-Jen Chen, Shao-Hsing Weng, and Yun-Wei Lin*. (2012) HSP90 inhibition induced cytotoxicity through down-regulation of Rad51 and thymidine phosphorylase expression in human non-small cell lung cancer cells. Abstract No. P032. The 27th Joint Annual Conference of Biomedical Sciences, National Defense Medical Center, Taiwan. March 17 – 18.

24.Yu-Ching Huang, Sheng-Chieh Tseng, Shao-Hsing Weng, Huang-Jen Chen, and Yun-Wei Lin*. (2012) Down-regulation of thymidine phosphorylase expression by 17-AAG enhances the cytotoxic effect of cisplatin in human lung cancer cells. Abstract No. P41. The International Symposium in Commemoration of the 5th Anniversary of College of Life Sciences, China Medical University, Taiwan. May 04.

25.Hsien-Chun Chiu, Ting-Yu Wo, Yi-Jhen Huang, Yu-Ching Huang, Sheng-Chieh Tseng, Huang-Jen Chen, and Yun-Wei Lin*. (2013) Inhibition of p38 MAPK-dependent MutS homologue-2 (MSH2) expression by metformin sensitize human lung squamous cancer cells to gefitinib. Abstract No. P359. 2013 The 28th Joint Annual Conference of Biomedical Sciences, National Defense Medical Center, Taiwan. March 23 – 24.

26.Sheng-Chieh Tseng, Yu-Ching Huang, Huang-Jen Chen, Hsien-Chun Chiu, Yi-Jhen Huang, Ting-Yu Wo, and Yun-Wei Lin*. (2013) Role of ERCC1 in metformin enhancing paclitaxel-induced cytotoxicity. Abstract No. 1283. Session ID: Carcinogensis 2: Molecular Carcinogensis. AACR Annual Meeting 2013. Washington Convention Center, Washington, DC. April 610.

27.Yu-Ching Huang, Huang-Jen Chen, Sheng-Chieh Tseng, Shao-Hsing Weng, Hsien-Chun Chiu, Ting-Yu Wo, Yi-Jhen Huang, and Yun-Wei Lin*. (2013) Metformin induces cytotoxicity by TP and ERCC1 decrease. Abstract No. 1301. Session ID: Carcinogensis 2: Molecular Carcinogensis. AACR Annual Meeting 2013. Washington Convention Center, Washington, DC. April 610.

28.Yun-Wei Lin. (2013) Role of pemetrexed in DNA repair capacity and cell survival affected by resveratrol. Abstract No. LBP26. IBMS-JSBMR 2013. Kobe International Conference Center & Kobe Portopia Hotel Kobe, Japan. May 28 – June 01.

29.Yun-Wei Lin, Hsien-Chun Chiu, Jhan-Jhang Syu, Yun-Ting Jian, and Chien-Yu Chen (2014). Enhancement of thymidine phosphorylase downregulation by erlotinib enhances cytotoxicity affected by tamoxifen in human non-small cell lung cancer cells. Abstract No. A33. AACR special Conference on RAS Oncogene: From Biology to Therapy. Lake Buenea Vista, Florida. February 24– 27.

30.Jhan-Jhang Syu, Yun-Ting Jian, Chien-Yu Chen, Hsien-Chun Chiu, Yi-Jhen Huang, Ting-Yu Wo, Yi-Jun Jian, and Yun-Wei Lin*. (2014) Down-regulation of MSH2 expression by Hsp90 inhibition enhances cytotoxicity affected by tamoxifen in human lung cancer cells. Abstract No. P784. 2014 The 29th Joint Annual Conference of Biomedical Sciences, National Defense Medical Center, Taiwan. March 15 – 16.

31.Hsien-Chun Chiu, Jhan-Jhang Syu, and Yun-Wei Lin*. (2014) Down-regulation of MSH2 expression by Hsp90 inhibition enhances pemetrexed-induced cytotoxicity in human lung cancer cells. ICBPS 2014: International Conference on Biomedicine and Pharmaceutical Sciences, Tokyo, Japan. May 29-30.

32.Tai-Jing Wang, Po-Yuan Chang, Jhan-Jhang Syu, Yi-Jun Jian, Chien-Yu Chen, Yun-Ting Jian, and Yun-Wei Lin*. (2015) Resveratrol enhances etoposide-induced cytotoxicity through down-regulating XRCC1 expression in human lung cancer cells. Abstract No. P478. 2015 The 30th Joint Annual Conference of Biomedical Sciences, National Defense Medical Center, Taiwan. March 15 – 16.

33.Jen-Chung Ko, Jyh-Cheng Chen, Jhan-Jhang Syu, Tai-Jing Wang, Po-Yuan Chang, Chien-Yu Chen, Yun-Ting Jian, Yi-Jun Jian, and Yun-Wei Lin*. (2015) Down-regulation of XRCC1 by resveratrol enhances etoposide-induced cytotoxicity. The IRES-3rd International Conference on Medical and Health Science, Seoul, South Korea. May 24.

34.Jyh-Cheng Chen, Tai-Jing Wang, Hao-Yu Zheng, Wen-Ching Chen, and Yun-Wei Lin*. (2016) Inhibition of X-ray repair cross-complement group 1 (XRCC1) expression by curcumin enhances cisplatin-induced cytotoxicity in human lung cancer cells. Abstract No. 1035. The 6th International Congress on Chemical, Biological and Environmental Sciences (ICCBES), Osaka, Japan. May 10– 12.

35.Yuan-Cheng Lin, Jyh-Cheng Chen, Peng-Fang Ma, Chia-Hung Wu, Yi-Shuan Peng, Hao-Yu Zheng, and Yun-Wei Lin*. (2018) Curcumin Enhances Gemcitabine-induced Cytotoxicity Via Down-Regulation Of MutS Homolog 2 (MSH2) Expression In Human Lung Adenocarcinoma A549 Cells. Abstract No. CM118. The 33th Joint Annual Conference of Biomedical Sciences, National Defense Medical Center, Taiwan. March 24 – 25.

36.Peng-Fang Ma, Jyh-Cheng Chen, Yuan-Cheng Lin, Chia-Hung Wu, Yi-Shuan Peng, Hao-Yu Zheng, and Yun-Wei Lin*. (2018) Astaxanthin enforces cytotoxicity via p38 MAPK mediated Xeroderma pigmentosum complementation group C (XPC) down-regulation in human lung cancer cells. Abstract No. CM117. The 33th Joint Annual Conference of Biomedical Sciences, National Defense Medical Center, Taiwan. March 24 – 25.

37.Jen-Chung Ko, Jyh-Cheng Chen, Ting-Chuan Yen, Tzu-Ying Chen, Yuan-Cheng Lin, Peng-Fang Ma, and Yun-Wei Lin*. (2019) Nitroglycerin induced cytotoxicity in human lung cancer cells via AKT inactivation and thymidylate synthase (TS) down-regulation. (Poster Presentation GAOM-02) 23rdGlobal Annual Oncologists Meeting, Yokahama, Japan. July 15-16.

 

研究計畫

1.探索抑制熱休克蛋白90活性如何向下調控人類肺癌細胞內著色性乾皮互補組蛋白C的表現與核酸修補能力進而增加化療藥物敏感性之分子機轉MOST 108-2320-B-415-004,科技部, 108/08/01~109/07/31

2.蝦紅素向下調控人類肺癌細胞內著色性乾皮互補組蛋白C表現在增加得舒緩毒殺非小細胞肺癌細胞的分子機轉,MOST 107-2320-B-415-007-,科技部, 107/08/01~108/07/31

3.鹽黴素與硝化甘油導致胸腺嘧啶合成酶及乙醛去氫酶1A1表現下降在增加人類非小細胞肺癌細胞對於化療藥物順鉑敏感性之角色,MOST 107-2314-B-002-236-,科技部,107/08/01~108/07/31 [共同主持人]

4.滅糖敏藉由MKK3/6-p38 MAPK 訊號失活所導致MSH2表現下降進而增加標靶藥物艾瑞莎毒殺肺癌細胞的角色,MOST 105-2314-B-002-112,科技部,105/08/01~106/07/31

5.機能性水稻優質安全生產技術建立及加值產品研發,行政院農業委員會農試所嘉義分所,105/02/28~105/11/30

6.雌性激素受體拮抗劑向下調控thymidine phosphorylase表現在增加表皮生長因子受體抑制劑與化療藥物毒殺非小細胞肺癌細胞的分子機轉,MOST 104-2314-B-415-002,科技部,104/08/01~105/07/31

7.探索抑制熱休克蛋白90活性如何向下調控非小細胞肺癌細胞內ERCC1的表現與核酸修補能力進而增加化療藥物敏感性之分子機轉,NSC 102-2320-B-415 -006,國科會,102/08/01~103/07/31

8.滅糖敏向下調控核酸代謝酵素thymidine phosphorylase表現在增加肺癌細胞對化療藥物順鉑與標靶藥物艾瑞莎敏感性的分子機轉,NSC 102-2314-B-002 -095,國科會, 102/08/01~103/07/31

9.大黃素調控人類肺癌細胞內Rad51ERCC1對抗表皮生長因子受體抑制劑與化療藥物抗藥性的分子機轉,NSC 99-2320-B-415-001-MY3,國科會, 99/08/01~102/07/31

10.探索多苯環芳香烴調控Rad51基因與蛋白質表現之分子機制,NSC 97-2311-B-415-001-MY3,國科會,97/08/01~100/07/31

11.探討持續性p38 MAPK活化促進MKP-1蛋白質分解的分子機轉,NSC 96-2311-B-415-004,國科會,96/8/01~97/07/31

12.探討多苯環芳香誘發持續性p38 MAPK活化的分子機轉NSC 95-2311-B-415-005,國科會,95/11/01~96/07/31

 

獲獎榮譽

1.科技部108年度補助大專校院獎勵特殊優秀人才獎勵

2.科技部106年度補助大專校院獎勵特殊優秀人才獎勵

3.清華大學生命科學院第七屆傑出校友獎

4.科技部105年度補助大專校院獎勵特殊優秀人才獎勵

5.科技部104年度補助大專校院獎勵特殊優秀人才獎勵

6.103年度教育部大專院校獎勵特殊優秀人才

7.102年度教育部大專院校獎勵特殊優秀人才

8.102年嘉義地區社會優秀青年

9.101學年度國立嘉義大學教學肯定獎

10.行政院國家科學委員會101年度補助大專校院獎勵特殊優秀人才獎勵

11.101年度教育部大專院校獎勵特殊優秀人才

12.行政院國家科學委員會100年度補助大專校院獎勵特殊優秀人才獎勵

13.100學年度國立嘉義大學教學評量績優教師

14.行政院國家科學委員會99年度補助大專校院獎勵特殊優秀人才獎勵

15.99學年度教學卓越計畫『基礎分子生物學與實作之創新教材製作』優良社群

16.98學年度國立嘉義大學教學評量績優教師

 



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