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20208月份
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最後更新2020/07/29
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::: * 首頁 > 師資陣容new5 > 鄭建中教授

* * 鄭建中教授
*

友善列印

鄭建中 教授    Dr. Chien-Chung Cheng

現職:國立嘉義大學應用化學系教授

+886-(0)5-2766084E-mail: cccheng@mail.ncyu.edu.tw

生物無機;核酸化學;生物有機化學

 

一、學歷

美國紐約州立大學石溪分校化學系博士(1989-1993)

東海大學化學系學士 (1985)

 

二、經歷

嘉義大學應用化學系教授(2006/08-迄今)

上海交通大學化學化工學院,訪問學者,2013/10

吉林大學超分子及材料國家重點實驗室,訪問學者,2013/08

淡江大學生命科學研究所合聘教授 (2002/08-2006/07)

淡江大學化學系教授 (2005/02-2006/07)

淡江大學化學系副教授 (2001/08-2005/02)

中央研究院化學所副研究員 (2000/5-2001/07)

中央研究院化學所助研究員(1996/02-2000/05)

美國北卡羅萊那大學教堂山分校博士後研究 (1993-1995)

 

三、專業領域:

生物無機;核酸化學;生物有機化學

 

四、連絡方式(Tel and FAX)

Tel: +886- 05-2766084; 

Fax: +886-05-2717901; 

E-mail: cccheng@mail.ncyu.edu.tw

 

五、研究方向:

1. DNA/RNA結構及生物功能:化學探針研究;化學感測物;含金屬之抗腫瘤試劑;DNA藥物試劑;專一辨識化學分子之DNA試管篩選

2. 化學在綠色生物材料及催化:模擬酵素催化作用;綠色化學之高溫菌催化反應;化學分子對斑馬魚的生物模擬作用;植物的活性分子分析

3. 化學分子之運送:金屬藥物的蛋白質體的作用;天然藥物修飾成運送載體;功能性脂肪球

 

六、選列期刊發表(Selected Publications)  校務系統研究成果

1.     Cheng, C.-C.; Lu, Y.-L.; Lo, C.-J. “DNA cleavage of Water-soluble Ruthenium(III) Complexes Containing Pyridiyl-Schiff Based in the Presence of H2O2,” Bull. Inst. Chem. Acad. Sinica 1997, 44, 61-69.

 

2.     Cheng, C.-C. and Pai, C.-H. “Specific Displacement of Glutathione from the Pt(II)-Glutathione Adduct from the Pt(II)-Glutathione Adduct,” J. Inorg. Biochem. 1998, 71, 109-113.

 

3.     Cheng, C.-C.; Jian, Y.-H.; Lo, C.-J. and Cheng, J.-W. “Design and Characterization of a Short HMG-I / DAT1 Peptide that Binds Specifically to the Minor Groove of DNA,” J. Chin. Chem. Soc. 1998, 45, 619-624.

 

4.     Cheng, C.-C. and Lu, Y.-L. “Novel Water-Soluble 4,4’-Disubstituted Ruthenium(III)-Salen Complexes in DNA Stranded Scission,” J. Chin. Chem. Soc. 1998, 45, 611-617.

 

5.     Cheng, C.-C. and Lu, Y.-L. “Cleavage of Pt-S bond of Platinum-thiolated Complexes Mediated by Cu(II) and Zn(II) ain Phosphate buffer,” Chem. Commun. 1998, 253. 5.504

 

6.     Carter, P. J.; Cheng, C.-C. and Thorp, H. H. “Oxidation of DNA and RNA by oxoruthenium(IV) Metallointercalators: Visualizing the Recognition Properties of  Dipyridophenazine by High-Resolution Electrophoresis,” J. Am. Chem. Soc. 1998, 120, 632-642.

 

7.     Cheng, C.-C.; Kuo, Y.-N.; Chuang, K.-S.; Luo, C. F. and Wang, W. C. “CoII (HAPP) (TFA)2 Complex: a DNA Bulge-Specific Probe,” Angew. Chem. Intl. Ed. Engl., 1999, 38, 1255-1257.

 

8.     Cheng, C.-C. and Liu, M.-C. “Novel Ca2+-Specific Receptors Derived from 3-Formyl-2-Hydroxybenzoic Acid,” Tetrahedron Lett., 2000, 41, 10047-10053.

 

9.     Cheng, C.-C.; Lee, W.-L.; Su, C.-K.; Liu, C.-L. “Determination of DNA Covalent Bond Formation of Ru(terpy)(tmephen)Cl+: A Potential Metal-Based Anticancer Drug,” J. Chin. Chem. Soc. 2000, 47, 213-220.

 

10.  Yang, C.-H; Chou, P.-J.; Zhen, Chang, J.-C.; Cheng, C.-C. “Preferential binding to DNA sequences of peptides related to a novel XPRK motif,” Bioorganic and Medicinal Chemistry 2003, 11, 3279-3288.

 

11.  Ong, C. W.; Chang, Y. A.; Wu, J.-Y. and Cheng, C.-C. “Novel design of a pentacyclic scaffold as structural mimic of saframycin A,” Tetrahedron 2003, 59, 8245-8249.

 

12.  Cheng, C.-C.; Hung, S.-M.; Yeh, C.-Y.; Chang, C.-S. and Wang, W. J. “Novel DNA binding agents: hydrazone-based helical trinuclear Ag complexes,” J. Chin. Chem. Soc. 2003, 50, 189-192.

 

13.  Cheng, C.-C.; Huang-Fu, W.-C.; Hung, K.-C.; Chen, P.-J.; Wang, W. J.; Chen, Y.-J. “Mechanistic Aspect of Co(HAPP)(TFA)2 in DNA Bulge-Specific Recognition,” Nucleic Acids Research 2003, 31, 2227-2233.

 

14.  Chen, Y.-J.; Chen, P.-J.; Wang, H.-T.; Cheng, C.-C. ”Specific Recognition of DNA Bulge Structure by Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry,” Rapid Comm. Mass Spec. 2004, 18, 609-616.

 

15.  Chang, J.- C.; Yang., C.- H.; Chou, P.- Y.; Yang, W.- H.; Chou, I.- C. Lu, C- T.; Lin, P.- H.; Hou, P. C.- W.; Jeng, K.- C. G.; Cheng, C.- C. and L. Sheh “DNA Sequence-specific Recognition of Peptides Incorporating the HPRK and Polyamide Motifs,” Bioorganic and Medicinal Chemistry 2004, 12(1) , 53-61

 

16.  Lin, C.-C.; Hung, S.-M.; Lee, K.-C. and Cheng, C.-C. “pH Dependent Thermal Stabilization of DNA by Glcb(1→3)GlcNAcb1→STol,” J. Chin. Chem. Soc. 2004, 51(3), 655-658.

 

17.  Cheng, C.-C.; Huang, Y.-C. and Liu., M.-C. “DNA Hydrolysis Catalyzed by Tris(diisopropyl-1,4,7- triazacyclononanes)ethane Metal Complexes” J. Chin. Chem. Soc. 2004, 51(5B), 1201-1208.

 

18.  Chen, C.-T.; Lin, J.-S.; Kuo, J.-H.;Weng, S.-S.;Cuo, T.-S.; Lin, Y.-W.; Cheng, C.-C.; Huang, Y.-C.; Yu, J.-K., Chou, P.-T. “Site-Selective DNA Photocleavage Involving Unusual Photoinitiated Tautomerization of Chiral Tridentate Vanadyl(V) Complexes Derived from N-Salicylidene <!--[if !vml]--> <!--[endif]-->-Amino Acids,” Org. Lett., 2004, 6(24), 4471 -4474.

 

19.  Cheng, C.-C.; Hung, K. C.; Huang-Fu, W. C. “Differentiate RNA single-stranded region of the branched structures and hairpin loops by an octahedral cobalt(II) complex” J. Chin. Chem. Soc. 2005, 52, 1291-1297.

 

20.  Hui-Huang Hsu,* Chao-Hsun Yang, Cheng-Wei Hsieh, and Chien-Chung Cheng, “Networked Information Integration for Protein Identification,” Journal of Information Technology, 2008, 9(1), 101-109.

 

21.  Wang YH, Wen CC, Yang ZS, Cheng CC, Tsai, JN, Ku CC, Wu HJ and Chen YH* “Development of a whole-organism model to screen new compounds for sun protection.” Marine Biotechnology, 2008, Online Original Article

 

22.  Ming-Yi Ho, Yu-Tse Shieh , Chung-Lin Liao , Yau-Hung Chen , Chien-Chung Cheng, “Functional dihydro-1H-imidazole derivatives for MALDI signal enhancement of a lysine-specific chemical modification” J. Chin. Chem. Soc. 2009, 56, 987-994.

 

23.  Yun-Hsin Wang, Chien-Chung Cheng, Wen-Jie Lee, Min-Lun Chiou, Chiung-Wen Pai, Chi-Chung Wen, Wei-Li Chen, and Yau-Hung Chen. “A novel phenotype-based approach for systematically screening antiproliferation metallodrugs”, Chemico-Biological Interactions, 2009, 182, 84–91.

 

24.  Ming-Yi Ho, Min-Lun Chiou, Ruei-Chi Chang, Yau-Hung Chen, Chien-Chung Cheng. “Outer membrane protein OmpF involved in the transportation of polypyridyl ruthenium complexes into Escherichia coli” J. Inorg. Biochem. 2010, 104, 614-617.

 

25.  Hsi-Chu Peng, Yun-Hsin Wang, Chi-Chung Wen, Wei-Hua Wang, Chien-Chung Cheng, Yau-Hung Chen “Nephrotoxicity assessments of acetaminophen during zebrafish embryogenesisComp. Biochem. Physiol. C. 2010, 151, 480-486.

 

26.  Yau-Hung Chen,* Chien-Hui Chiou, Wei-Li Chen, Yu-Ru Jhou, Ya-Ting Lee, Chien-Chung Cheng,* “Rhodamine-Ethylenediol, A Novel Vital Fluorescent Probe for Labelling Alkaline Phosphatase-Rich Organelles” J. Chin. Chem. Soc. 2010, 57, 1257-1261.

 

27.  Yau-Hung Chen*, Min-Chuan Chiou, Yun-Feng Liao, Jen-Ning Tsai, Chi-Chung Wen, Yun-Hsin Wang, and Chien-Chung Cheng* “Resveratrol Treatment Attenuates the Wound-induced Inflammation in Zebrafish Larvae through the Suppression of Myeloperoxidase Expression” J. Food. Drug Anal. 2011, 19, 167-173.

 

28.  Ming-Yi Ho, Min-Lun Chiou, Wan-Shan Du, Fang Ying Chang, Yau-Hung Chen, Yu-Jong Weng, Chien-Chung Cheng,* “Inductive properties of polypyridyl ruthenium complexes significantly regulate various protein distributions in Escherichia coli” J. Inorg. Biochem. 2011,105, 902-910.

 

29.  Chen YH, Tsai IT, Wen CC, Wang YH, Cheng CC, Hu SC, Chen YH*, “Fin-reduction is a novel and unexpected teratogenic effect of amikacin-treated zebrafish embryos” Toxicology Mechanisms and Methods 2012; 22(2): 151–158.

 

30.  Tsai IT, Yang ZS, Lin ZY, Wen CC, Cheng CC, Chen YH, “Flavone is efficient to protect zebrafish fins from UV-induced damage”, Drug and Chemical Toxicology, 2012, 35(3), 341-6.

 

31.  Yeh CH, Liao YF, Chang CY, Tsai JN, Wang YH, Cheng CC, Wen CC, Chen YH* “Caffeine treatment disturbs the angiogenesis of zebrafish larvae.” Drug Chem. Toxicol. 2012, 35, 361-365.

 

32.  Yu-Ru Jhou, Chien-Hui Chiou, Lin-Kia Ni, Li-Chou Chen, Yau-Hung Chen, and Chien-Chung Cheng ”Cellular uptake of a polypyridyl ruthenium complex revealed using a fluorescent rhodamine-modified ruthenium complex, J. Chin. Chem. Soc. 2012, 59, 1053-1057.

 

33.  Der-Lii M. Tzou,* Lin-Kai Ni, Mei-Man Chen, Min-Chuan Chiou, Li-Chou Chen, Shan-Te Hsu, Kuo-Lung Ku, and Chien-Chung Cheng,* “Solid-state 13C NMR analysis of Phalaenopsis tissues during the growth period and spiking induction”, J. Chin. Chem. Soc. 2013, 60, 1107-1112. (Cover) (2014 CCS Award)

 

34.  Li-Chou Chen, Shih-Shan Lin, Cun-Zhao Li, Hsiu-Fu Hsu,* Yu-Jong Weng, Chien-Chung Cheng,* “Dynamic structural transformation of resveratrol-modified stearate liposomes to a metastable helical supra-structure for drug release”, J. Chin. Chem. Soc. 2013, 60, 1099-1102.

 

35.  Cheng CC*, Chou CY, Chang YC, Wang HW, Wen CC, Chen YH*, “Protective role of comfrey leave extracts on UV-induced zebrafish fin damages” Journal of Toxicologic Pathology, 2014, 27, 115-121.

 

36.  Shan-Te Hsu, Wan-Shan Du, Hsing-Chin Liu, Le-Chou Cheng, Chien-Chung Cheng* “Protein Redistribution and Stalk Localization Following Temperature Variation in the Growth and Spiking Period of Phalaenopsis”, J. Chin. Chem. Soc. 2014, 61(11), 1231-1236

 

37.  Yue-Jyun Chen, Chi-Yuan Chou, Chi-Chung Wen, Chen-Yu Fan, Chien-Chung Cheng *, Yau-Hung Chen “UV-protective activities of pineapple leaves extract in zebrafish embryos” 2015, submitted

 

38.  Chen, Chien-Han; Hu, Tsung-Hao; Huang, Tzu-Chiao; Chen, Ying-Lan; Chen, Yet-Ran; Cheng, Chien-Chung; Chen, Chao-Tsen  "A SiteSpecific Telomeric GQuadruplex Alkylating Agent", 2015 submitted

 

39.  Deyue Yan, Lin-Kai Ni, Ho-Lun Chen, Li-Chou Chen, Yau-Hung Chen, Chien-Chung Cheng "Amphiphilic Nanoparticles of Resveratrol-Norcantharidin to Enhance the Toxicity in Zebrafish Embryo", 2016 submitted

 

 

專書

三大科技革命與時空宇宙:生化科技革命 2002 ,淡江大學出版社。

 

專利

1. A specific DNA probe: CoII(HAPP)(TFA)2 complexes (USA Patent No. 6,348,588B1, 2002)

2. Nucleic acid bulge-detecting agent (US Patent No. 6,770,760, August 3, 2004)

3. 專利:「核酸突起結構的偵測劑」,台灣專利案(證號:I2224522003)

 

七、 研討會論文

國際學術邀請演講2001-迄今)

1. 第十屆國際生物無機會議,義大利的佛羅倫斯,200182631日。

Mechanistic studies of a DNA/RNA Bulge-specific detecting agent: Co(HAPP)(TFA)22+

2. 8屆國際應用生物無機會議,香港的香港大學,2004425

     “Differentiate RNA Branched Structures by Selective Cleavage with an Octahedral Co (II) Complex”

3. 3屆亞洲生物無機會議,南京大學,20061031114日。
     “Study of the Structure-Reactivity Relationship of Polypyridyl Ruthenium Complexes by Proteomics”

4. 2nd Korea-Taiwan Bilateral Symposium, Sogang University, Korea, Oct 23-26, 2009

     Title:Outer membrane protein OmpF involved in the transportation of polypyridyl ruthenium complexes into Escherichia coli”.

5. Taipei-Shanghai Symposium of Materials Chemistry台北-上海材料化學學術研討會Academia Sinica, Taipei, Taiwan, Nov 27- Dec 2, 2009. Alkaline Phosphatase-Specific Recognition by a Fluorescent Probe of Rhodamine-Ethylenediol Disclosed by Zebrafish

6. Taipei-Shanghai Symposium of Materials Chemistry(滬台材料化學學術研討會)Shanghai, July 21-24, 2011

     “Specific Chiral Recognition of Monosaccharides by DNA Biosensors”

7. The Supramolecular Symposium: Dynamics and Adaption, Hangzhou, China, November 4-6th, 2012. “Formation of Self-Assembling Helical Conformation by Aliphatic Resveratrol Derivatives”

8. 2013 Taipei-Shanghai Symposium of Materials Chemistry(滬台材料化學學術研討會), Kaohsiung, November, 8-12, 2013. ” Dynamic structural transformation of resveratrol-modified stearate liposomes to a metastable helical supra-structure for drug release”

9. 2014 Korea-Taiwan Bilateral Symposium, Sogang University, Korea, Jan. 12-16, 2014. “Self-Assembly of
    Resveratrol-based Stearate Liposomes for Drug Delivery”

10. The 8th Taiwan-Japan Bilateral Symposium on Architecture of Functional Organic Molecules, Kyushu University, Japan, November 27-29, 2014. “Self-Assembly of 4-Vinylphenol Based Amphiphiles for Drug Delivery and Release”

 

短期參訪演講

2014 杭州浙江大學高分子所邀請訪問。時間:2014052629日;地點:浙江大學玉泉校區,

講題:Investigation of Potential Antitumor Ruthenium Complexes by Proteomics and Development of Resveratrol-Modified Liposomes for Drug Delivery

 

國內會議邀請演講(選列)

2007台灣生物無機年會 (嘉義大學應化系主辦)

2008無機錯鹽研討會(東吳大學化學系主辦)

2010台灣化學年會(台灣大學化學系主辦) ”Ru-protein interactions of antitumor reagents of polypyridiyl Ru(II) complexes in E. coli revealed by metalloproteomics

2011台灣化學年會(由清華大學化學系主辦)”Trans Influence of Polypyridyl Ru(II) Complexes Significantly Influenced the Ru-Protein Interactions in Escherichia coli Revealed by Metalloproteomics

2014 Southern Taiwan Frontier Conference in Applied Chemistry, Keynote Lecture, National Ping-Tung University, Nov.15-16, 2014Multi-Functional Liposomes Assembled by Natural-Product-Based Materials for Drug Delivery

 

國際會議壁報論文發表 (選列 2002 -迄今)

1. 第三十五屆國際配位化學會議 (35th International Conference of Coordination Chemistry)

        地點:德國的海德堡(HeidelbergGermany);時間:2002 719日至26

        題目:Novel DNA binding agents: the self-assembling trinuclear Ag complexes

2. 第十一屆國際生物無機會議 (11th International Conference of Biological Inorganic Chemistry)

        地點:澳洲的凱恩斯;時間:2003 719日至23日,會期共五天。

        題目:DNA hydrolysis by Tris-triazacyclononanes Metal Complexes

3. 14屆國際均勻相催化化學會議 (14th International Symposium on Homogeneous Catalysis)

        地點:德國的慕尼黑;時間:2004759日,會期共五天。

       題目:Catalytic Epoxidation by Spatial Orientation of Tris(1,4,7-triazacyclononanemethyl)- ethane Metal Complexes

4. 第十三屆國際有機金屬化學導引有機合成會議(OMCOS-13),

           地點:瑞士的日內瓦,時間:200571721日,

題目:Hydrophobic Cavity of Macrocyclic Metal Complexes in Catalytic Epoxidation

5. 第十二屆國際高分子暨有機化學會議12th International Conference on Polymers and Organic Chemistry地點:日本岡崎(Okazaki),時間:2006727

6. 第十三屆國際生物無機會議 (13th International Conference of Biological Inorganic Chemistry),地點:奧地利的維也納,時間:2007715日至20

        題目:Structure-Reactivity Relationship of Polypyridyl Ru Complexes in Proteomics and Zerbrafish 
7. 第十四屆國際進階選擇性催化會前會議(ICC-14 Pre-Symposium)
        地點:日本的京都,時間:2008 7 8 12日,

      題目:Tris(1,4,7-triazacyclononanemethyl)ethane-based Multi-nuclear Metal Complexes in Catalytic Epoxidation and DNA Hydrolysis

8. 第四屆亞洲生物無機會議 (4th Asia Biological Inorganic Chemistry)

      地點:韓國濟州島,時間:2008119日至13

      題目一:Stress-Regulated Transportation of E. Coli. Induced by Polypyridyl Ruthenium Complexes by Metalloprotomic 
      題目二:Synthesis of Fluorescent Polypyridyl Ruthenium Complexes for Metallopharmaceuticals

      題目三:Catalytic Epoxidation and DNA Hydrolysis by Tris(1,4,7-triazacyclononanemethyl)ethane-based Multi-nuclear Metal Complexes

      題目四:Metal-dependent hydrolysis of phosphoester using hyperthermophilic proteins

9. 第十四屆國際生物無機會議 (14th International Conference of Biological Inorganic Chemistry),地點:日本的名古屋,時間:2009725日至30

        題目一:Stress-Regulated Transportation by Polypyridyl Ruthenium Complexes in E. Coli. Identified by Metalloprotomics 

      題目二:Metalloproteomics of Polypyridyl Ruthenium Complexes Explored by LC-Nanospray-MS.

10.第三十九屆國際配位化學會議 (39th International Conference of Coordination Chemistry)

        地點:澳洲的阿得雷德(AdelaideAustralia);時間:2010 725日至30

      題目:Modified Bipyridine Ligand of Ruthenium Complexes Related to the Anti-proliferations in Zebrafish

11. 第十五屆國際生物無機會議 (15th International Conference of Biological Inorganic Chemistry),地點:加拿大溫哥華 (Vancouver, Canada),時間:201187日至12

      題目:Trans-influence of polypyridyl ruthenium complexes related to various protein distributions in Escherichia coli by metalloproteomics

12. 15th International Symposium on Novel Aromatic Compounds (ISNA-15), Taipei, July 28-August 02, 2013.

“Resveratrol-modified Stearate Liposomes Induced Spontaneous Drug Release by Dynamic Structural Transformation”

 

 

國內之科普演講

2010 擔任「科學到民間-真理大學麻豆校區場次」義務講師;時間:1230日;地點:真理大學台南麻豆校區;( 慶祝科學月刊四十週年科學到民間科普系列講座);講題:生活分子與分子生活;

2012 擔任「科學到民間」系列講師,時間:0617日;地點:台北市立圖書館內湖分館;講題:生活分子與分子生活

2013高中優質化策略聯盟」邀請之科普講座。時間:0401日;地點:嘉義縣竹崎高中,講題:生活分子與分子生活

 

八、獲獎榮譽

1999 中國化學學會傑出青年化學獎章

1999 國科會績優新進研究人員

2001 國科會績優新進研究人員

2004 淡江大學92學年度優良導師獎

2012 嘉義大學100學年度教學績優/教學肯定獎

2013 嘉義大學101年度傑出通識教育教師獎

2014 中國化學會誌論文獎

 

九、學術專業服務經歷

2003200420052006台灣生物無機會議,籌備委員

200020012007台灣生物無機會議,主辦人

2000-2013 台灣生物無機小組,委員

2006 國科會自然處化學學門,諮詢委員

2006 95年中國化學年會,學術演講召集人

2007-2010 Asian Biological Inorganic Chemistry Organization committee member.

2010,第五屆亞洲生物無機會議,籌備委員

20112012,台灣生物無機協會,理事

2012-2014,台灣化學學會之嘉義分會理事

2013,台灣生物無機協會,監事

2015 台灣化學學會之嘉義分會理事

 

十、產學及其他相關服務

2000-2001,百恩諾生物科技公司,顧問

2010-2014,百菲生技股份有限公司,顧問

2011,嘉大蘭花研發團隊成員之一。開發保養產品「嘉蘭之心潤膚水」

2012,台南市101學年度教師甄試複試評審委員

2012,嘉大應化系之「嘉大白面膜」開發小組

201320142015 擔任「國家圖書館」之選書委員(知識性圖書組)

2014-presentSo Organic Biotech Enterprise (SOBE) LTD.,顧問


十一、教授課目

生物無機;核酸化學;生物有機化學



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