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last update time 2022/09/15
:::* Home > Professor > Chien-Chung Cheng

** Professor

Chien-Chung Cheng  

Professor, Department of Applied Chemistry, National Chia-Yi University,

Chia-Yi City, Taiwan, 60004, ROC




B.S. in Chemistry, Tung-Hai University, Taiwan, R.O.C. (1985);

Ph.D., State University of New York at Stony Brook (1989-1993);



Professor, National Chia-Yi University (2006/08- present)

Postdoctoral Fellow, University of North Carolina at Chapel Hill (1993-1995);

Assistant Research Fellow, Institute of Chemistry, Academia Sinica (1996-2000);

Associate Research Fellow, Institute of Chemistry, Academia Sinica (2000-2001);

Associate Professor, Department of Chemistry, Tamkang University (2001-2005/02);

Professor, Department of Chemistry, Tamkang University (2005/02-2006/7);

Professor, Graduate Institute of Life Sciences, Tamkang University (2003/02-2006/7). 

Visiting Professor, State Key Laboratory of Supramolecular Structure and Materials, Jilin University, China (2013/08-09)

Visiting Professor, School of Chemistry and Chemical Engineering, Shanghai Jiao-Tong University, China (2013/10-11)



1. Chinese Chemical Society Outstanding Young Chemist Award (1999).

2. National Science Council Outstanding Young Investigator Award (1999 and 2001);

3. Outstanding Student Advisor Award, 2004, Tamkang University

4. The Teaching Recognition Award, 2012, National Chia-Yi University.

5. Outstanding General Education Teaching Award of 2013, National Chia-Yi University

6. Best Article Award 2014, Chinese Chemical Society at Taipei


Research Interests:

1. To study the relationship between bio-molecules structures and their functions;

2. To mimic enzymes catalytic functions

3. To discover new chemotherapeutic agents (organic and inorganic) and DNA drugs

4. To explore chemical’s metabolic pathway using proteomics.

5. To develop the chemicals for cell transportation


Selected Publications

1.     Cheng, C.-C.; Lu, Y.-L.; Lo, C.-J. “DNA cleavage of Water-soluble Ruthenium(III) Complexes Containing Pyridiyl-Schiff Based in the Presence of H2O2,” Bull. Inst. Chem. Acad. Sinica 1997, 44, 61-69.


2.     Cheng, C.-C. and Pai, C.-H. “Specific Displacement of Glutathione from the Pt(II)-Glutathione Adduct from the Pt(II)-Glutathione Adduct,” J. Inorg. Biochem. 1998, 71, 109-113.


3.     Cheng, C.-C.; Jian, Y.-H.; Lo, C.-J. and Cheng, J.-W. “Design and Characterization of a Short HMG-I / DAT1 Peptide that Binds Specifically to the Minor Groove of DNA,” J. Chin. Chem. Soc. 1998, 45, 619-624.


4.     Cheng, C.-C. and Lu, Y.-L. “Novel Water-Soluble 4,4’-Disubstituted Ruthenium(III)-Salen Complexes in DNA Stranded Scission,” J. Chin. Chem. Soc. 1998, 45, 611-617.


5.     Cheng, C.-C. and Lu, Y.-L. “Cleavage of Pt-S bond of Platinum-thiolated Complexes Mediated by Cu(II) and Zn(II) ain Phosphate buffer,” Chem. Commun. 1998, 253. 5.504


6.     Carter, P. J.; Cheng, C.-C. and Thorp, H. H. “Oxidation of DNA and RNA by oxoruthenium(IV) Metallointercalators: Visualizing the Recognition Properties of  Dipyridophenazine by High-Resolution Electrophoresis,” J. Am. Chem. Soc. 1998, 120, 632-642.


7.     Cheng, C.-C.; Kuo, Y.-N.; Chuang, K.-S.; Luo, C. F. and Wang, W. C. “CoII (HAPP) (TFA)2 Complex: a DNA Bulge-Specific Probe,” Angew. Chem. Intl. Ed. Engl., 1999, 38, 1255-1257.


8.     Cheng, C.-C. and Liu, M.-C. “Novel Ca2+-Specific Receptors Derived from 3-Formyl-2-Hydroxybenzoic Acid,” Tetrahedron Lett., 2000, 41, 10047-10053.


9.     Cheng, C.-C.; Lee, W.-L.; Su, C.-K.; Liu, C.-L. “Determination of DNA Covalent Bond Formation of Ru(terpy)(tmephen)Cl+: A Potential Metal-Based Anticancer Drug,” J. Chin. Chem. Soc. 2000, 47, 213-220.


10.  Yang, C.-H; Chou, P.-J.; Zhen, Chang, J.-C.; Cheng, C.-C. “Preferential binding to DNA sequences of peptides related to a novel XPRK motif,” Bioorganic and Medicinal Chemistry 2003, 11, 3279-3288.


11.  Ong, C. W.; Chang, Y. A.; Wu, J.-Y. and Cheng, C.-C. “Novel design of a pentacyclic scaffold as structural mimic of saframycin A,” Tetrahedron 2003, 59, 8245-8249.


12.  Cheng, C.-C.; Hung, S.-M.; Yeh, C.-Y.; Chang, C.-S. and Wang, W. J. “Novel DNA binding agents: hydrazone-based helical trinuclear Ag complexes,” J. Chin. Chem. Soc. 2003, 50, 189-192.


13.  Cheng, C.-C.; Huang-Fu, W.-C.; Hung, K.-C.; Chen, P.-J.; Wang, W. J.; Chen, Y.-J. “Mechanistic Aspect of Co(HAPP)(TFA)2 in DNA Bulge-Specific Recognition,” Nucleic Acids Research 2003, 31, 2227-2233.


14.  Chen, Y.-J.; Chen, P.-J.; Wang, H.-T.; Cheng, C.-C. ”Specific Recognition of DNA Bulge Structure by Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry,” Rapid Comm. Mass Spec. 2004, 18, 609-616.


15.  Chang, J.- C.; Yang., C.- H.; Chou, P.- Y.; Yang, W.- H.; Chou, I.- C. Lu, C- T.; Lin, P.- H.; Hou, P. C.- W.; Jeng, K.- C. G.; Cheng, C.- C. and L. Sheh “DNA Sequence-specific Recognition of Peptides Incorporating the HPRK and Polyamide Motifs,” Bioorganic and Medicinal Chemistry 2004, 12(1) , 53-61


16.  Lin, C.-C.; Hung, S.-M.; Lee, K.-C. and Cheng, C.-C. “pH Dependent Thermal Stabilization of DNA by Glcb(1→3)GlcNAcb1→STol,” J. Chin. Chem. Soc. 2004, 51(3), 655-658.


17.  Cheng, C.-C.; Huang, Y.-C. and Liu., M.-C. “DNA Hydrolysis Catalyzed by Tris(diisopropyl-1,4,7- triazacyclononanes)ethane Metal Complexes” J. Chin. Chem. Soc. 2004, 51(5B), 1201-1208.


18.  Chen, C.-T.; Lin, J.-S.; Kuo, J.-H.;Weng, S.-S.;Cuo, T.-S.; Lin, Y.-W.; Cheng, C.-C.; Huang, Y.-C.; Yu, J.-K., Chou, P.-T. “Site-Selective DNA Photocleavage Involving Unusual Photoinitiated Tautomerization of Chiral Tridentate Vanadyl(V) Complexes Derived from N-Salicylidene <!--[if !vml]--> <!--[endif]-->-Amino Acids,” Org. Lett., 2004, 6(24), 4471 -4474.


19.  Cheng, C.-C.; Hung, K. C.; Huang-Fu, W. C. “Differentiate RNA single-stranded region of the branched structures and hairpin loops by an octahedral cobalt(II) complex” J. Chin. Chem. Soc. 2005, 52, 1291-1297.


20.  Hui-Huang Hsu,* Chao-Hsun Yang, Cheng-Wei Hsieh, and Chien-Chung Cheng, “Networked Information Integration for Protein Identification,” Journal of Information Technology, 2008, 9(1), 101-109.


21.  Wang YH, Wen CC, Yang ZS, Cheng CC, Tsai, JN, Ku CC, Wu HJ and Chen YH* “Development of a whole-organism model to screen new compounds for sun protection.” Marine Biotechnology, 2008, Online Original Article


22.  Ming-Yi Ho, Yu-Tse Shieh , Chung-Lin Liao , Yau-Hung Chen , Chien-Chung Cheng, “Functional dihydro-1H-imidazole derivatives for MALDI signal enhancement of a lysine-specific chemical modification” J. Chin. Chem. Soc. 2009, 56, 987-994.


23.  Yun-Hsin Wang, Chien-Chung Cheng, Wen-Jie Lee, Min-Lun Chiou, Chiung-Wen Pai, Chi-Chung Wen, Wei-Li Chen, and Yau-Hung Chen. “A novel phenotype-based approach for systematically screening antiproliferation metallodrugs”, Chemico-Biological Interactions, 2009, 182, 84–91.


24.  Ming-Yi Ho, Min-Lun Chiou, Ruei-Chi Chang, Yau-Hung Chen, Chien-Chung Cheng. “Outer membrane protein OmpF involved in the transportation of polypyridyl ruthenium complexes into Escherichia coli” J. Inorg. Biochem. 2010, 104, 614-617.


25.  Hsi-Chu Peng, Yun-Hsin Wang, Chi-Chung Wen, Wei-Hua Wang, Chien-Chung Cheng, Yau-Hung Chen “Nephrotoxicity assessments of acetaminophen during zebrafish embryogenesisComp. Biochem. Physiol. C. 2010, 151, 480-486.


26.  Yau-Hung Chen,* Chien-Hui Chiou, Wei-Li Chen, Yu-Ru Jhou, Ya-Ting Lee, Chien-Chung Cheng,* “Rhodamine-Ethylenediol, A Novel Vital Fluorescent Probe for Labelling Alkaline Phosphatase-Rich Organelles” J. Chin. Chem. Soc. 2010, 57, 1257-1261.


27.  Yau-Hung Chen*, Min-Chuan Chiou, Yun-Feng Liao, Jen-Ning Tsai, Chi-Chung Wen, Yun-Hsin Wang, and Chien-Chung Cheng* “Resveratrol Treatment Attenuates the Wound-induced Inflammation in Zebrafish Larvae through the Suppression of Myeloperoxidase Expression” J. Food. Drug Anal. 2011, 19, 167-173.


28.  Ming-Yi Ho, Min-Lun Chiou, Wan-Shan Du, Fang Ying Chang, Yau-Hung Chen, Yu-Jong Weng, Chien-Chung Cheng,* “Inductive properties of polypyridyl ruthenium complexes significantly regulate various protein distributions in Escherichia coli” J. Inorg. Biochem. 2011,105, 902-910.


29.  Chen YH, Tsai IT, Wen CC, Wang YH, Cheng CC, Hu SC, Chen YH*, “Fin-reduction is a novel and unexpected teratogenic effect of amikacin-treated zebrafish embryos” Toxicology Mechanisms and Methods 2012; 22(2): 151–158.


30.  Tsai IT, Yang ZS, Lin ZY, Wen CC, Cheng CC, Chen YH, “Flavone is efficient to protect zebrafish fins from UV-induced damage”, Drug and Chemical Toxicology, 2012, 35(3), 341-6.


31.  Yeh CH, Liao YF, Chang CY, Tsai JN, Wang YH, Cheng CC, Wen CC, Chen YH* “Caffeine treatment disturbs the angiogenesis of zebrafish larvae.” Drug Chem. Toxicol. 2012, 35, 361-365.


32.  Yu-Ru Jhou, Chien-Hui Chiou, Lin-Kia Ni, Li-Chou Chen, Yau-Hung Chen, and Chien-Chung Cheng ”Cellular uptake of a polypyridyl ruthenium complex revealed using a fluorescent rhodamine-modified ruthenium complex, J. Chin. Chem. Soc. 2012, 59, 1053-1057.


33.  Der-Lii M. Tzou,* Lin-Kai Ni, Mei-Man Chen, Min-Chuan Chiou, Li-Chou Chen, Shan-Te Hsu, Kuo-Lung Ku, and Chien-Chung Cheng,* “Solid-state 13C NMR analysis of Phalaenopsis tissues during the growth period and spiking induction”, J. Chin. Chem. Soc. 2013, 60, 1107-1112. (Cover) (2014 CCS Award)


34.  Li-Chou Chen, Shih-Shan Lin, Cun-Zhao Li, Hsiu-Fu Hsu,* Yu-Jong Weng, Chien-Chung Cheng,* “Dynamic structural transformation of resveratrol-modified stearate liposomes to a metastable helical supra-structure for drug release”, J. Chin. Chem. Soc. 2013, 60, 1099-1102.


35.  Cheng CC*, Chou CY, Chang YC, Wang HW, Wen CC, Chen YH*, “Protective role of comfrey leave extracts on UV-induced zebrafish fin damages” Journal of Toxicologic Pathology, 2014, 27, 115-121.


36.  Shan-Te Hsu, Wan-Shan Du, Hsing-Chin Liu, Le-Chou Cheng, Chien-Chung Cheng* “Protein Redistribution and Stalk Localization Following Temperature Variation in the Growth and Spiking Period of Phalaenopsis”, J. Chin. Chem. Soc. 2014, 61(11), 1231-1236


37.  Yue-Jyun Chen, Chi-Yuan Chou, Chi-Chung Wen, Chen-Yu Fan, Chien-Chung Cheng *, Yau-Hung Chen “UV-protective activities of pineapple leaves extract in zebrafish embryos” 2015, submitted


38.  Chen, Chien-Han; Hu, Tsung-Hao; Huang, Tzu-Chiao; Chen, Ying-Lan; Chen, Yet-Ran; Cheng, Chien-Chung; Chen, Chao-Tsen  "A SiteSpecific Telomeric GQuadruplex Alkylating Agent", 2015 submitted


39.  Deyue Yan, Lin-Kai Ni, Ho-Lun Chen, Li-Chou Chen, Yau-Hung Chen, Chien-Chung Cheng "Amphiphilic Nanoparticles of Resveratrol-Norcantharidin to Enhance the Toxicity in Zebrafish Embryo", 2016 submitted



1. A specific DNA probe: CoII(HAPP)(TFA)2 complexes (USA Patent No. 6,348,588B1, 2002).

2. Nucleic acid bulge-detecting agent (US Patent No. 6,770,760, August 3, 2004).

3. 專利:「核酸突起結構的偵測劑」,Taiwan Patent(NoI222452)2003, Taiwan.


Invited Lectures (International), 2001-Current

1. The 10th International Conference on Biological Inorganic Chemistry, Florence, Italia, Aug. 26-31, 2001.  “Mechanistic studies of a DNA/RNA Bulge-specific detecting agent: Co(HAPP)(TFA)22+

2. The 8th International Conference on Applied Biological Inorganic Chemistry, Hon Kong, Apr. 2-5, 2004.  “Differentiate RNA Branched Structures by Selective Cleavage with an Octahedral Co (II) Complex”

3. The 3rd Asian Biological Inorganic Chemistry Conference, Nanjiang, China, Oct. 31-Nov. 4, 2006.  Study of the Structure-Reactivity Relationship of Polypyridyl Ruthenium Complexes by Proteomics”

4. The 2nd Korea-Taiwan Bilateral Symposium, Sogang University, Korea, Oct 23-26, 2009.  “Outer membrane protein OmpF involved in the transportation of polypyridyl ruthenium complexes into Escherichia coli

5. 2009 Taipei-Shanghai Symposium of Materials Chemistry, Academia Sinica, Taipei, Taiwan, Nov 27- Dec 2, 2009. Alkaline Phosphatase-Specific Recognition by a Fluorescent Probe of Rhodamine-Ethylenediol Disclosed by Zebrafish

6. 2011 Taipei-Shanghai Symposium of Materials Chemistry, Shanghai, China, July 21-24, 2011. Specific Chiral Recognition of Monosaccharides by DNA Biosensors”

7. The Supramolecular Symposium: Dynamics and Adaption, Hangzhou, China, Nov. 4-6, 2012. “Formation of Self-Assembling Helical Conformation by Aliphatic Resveratrol Derivatives”

8. 2013 Taipei-Shanghai Symposium of Materials Chemistry, Kaohsiung, Nov. 8-12, 2013. ” Dynamic structural transformation of resveratrol-modified stearate liposomes to a metastable helical supra-structure for drug release”

9. 2014 Korea-Taiwan Bilateral Symposium, Sogang University, Korea, Jan. 12-16, 2014. “Self-Assembly of Resveratrol-based Stearate Liposomes for Drug Delivery”

10. The 8th Taiwan-Japan Bilateral Symposium on Architecture of Functional Organic Molecules, Kyushu University, Japan, Nov. 27-29, 2014. “Self-Assembly of 4-Vinylphenol Based Amphiphiles for Drug Delivery and Release”


Short-term Visiting Invitation

Invitation Lecture: Department of polymer Science and Engineering, Zhejiang University, May 26-29, 2014. “Investigation of Potential Antitumor Ruthenium Complexes by Proteomics and Development of Resveratrol-Modified Liposomes for Drug Delivery”



Others Academia Services

2006 Consultant, Chemistry Center, National Science Council

2007-2010 Organization Committee Member, Asian Biological Inorganic Chemistry.

2010 Organization Committee of the 5th Asia Biological Inorganic Chemistry

2011 Member of a board of directors, Taiwan Bioinorganic Society

2013 Member of Supervisors, Taiwan Bioinorganic Society

2013-2014, 2015-2016, Member of a board of directors, Chia-Yi Affiliate, Chemical Society Located in Taipei 





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