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20215月份
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最後更新2021/05/14
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::: * 首頁 > 師資陣容new5 > 賴寧生教授(合聘)

* * 賴寧生教授(合聘)
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友善列印

 賴寧生  教授



TEL:                (05)-2648000 ext. 5010 (O)


Fax:                (05)-2648506


[Education]


學歷            1982  國立陽明醫學院醫學士


                MB, National Yang-Ming Medical College


                Faculty of Medicine


                1995  國立陽明大學臨床醫學研究所博士


                MD., Ph.D.  National Yang-Ming University


                Faculty of Clinical Medicine Research


 


[Postdoctoral Training]


醫師訓練        1981-1982  台北榮民總醫院實習醫師


                1984-1988  台中榮民總醫院內科部住院醫師   


1988-1989  台中榮民總醫院內科部過敏免疫風濕科住院總醫師 


1989-1996  台中榮民總醫院內科部過敏免疫風濕科主治醫師


1996-9      國立陽明醫科大學醫學院副教授


                1996.7-     嘉義榮民醫院風濕科主任


                1996.7-    嘉義榮民醫院醫學研究部主任


                1996.7-         嘉義醫療網醫療品質召集委員


                1996-1997   嘉義醫療網醫師教育委員會委員


1997.12-       嘉義榮民醫院內科部主任


1997.13-       中央健保局南區分局審核委員


1999.8-    醫杏風濕病關懷協會理事長


2000.7      慈濟大林醫院內科部主任兼過敏免疫風溼科主任


2001.4      慈濟大學醫學院專任副教授


2001.8.        慈濟大林醫院研究部主任


2001.9      國立嘉義大學理工學院副教授


                2001.11      中華民國第八屆風濕病醫學會理事


                2002.4      國立中正大學分子生物研究所副教授


                2003 -2005      嘉義縣醫師公會監事


                2004. 11        中華民國第九屆風濕病醫學會理事


2005. 9    慈濟大林醫院副院長


2006.12      中華民國第九屆免疫醫學會理事


2007.11     中華民國第十屆風濕病醫學會理事


2008.10-2012    慈濟大林醫院斗六分院院長


2009.6 - 2012   雲林縣醫師公會理事


2009.7      慈濟大學醫學院專任教授


2010.7      國立中正大學分子生物研究所兼任教授


2012-8      慈濟大林綜合醫院院長


2012-8      嘉義縣醫師公會理事


2012-8      中華民國區域醫院協會理事


2012-10     嘉義縣症府醫事審議委員會委員


2013-9      嘉義縣症府醫懲戒委員會委員


2013-1      南區醫療網聯繫會議委員


2013-3      台灣素食營養學會監事


2013-11      中華民國第十屆風濕病醫學會理事


2013-12     慈濟基金會教育志策會董事


2014-1      嘉義縣政府縣政顧問


2014-4      南區健保審核委員


 


[Licensure]


醫學執照        1982    中華民國醫師考試及格


                1982    美國醫師FMGEM考試及格


                1983    中華民國醫師高考及格


                1988    中華民國內科專科醫師考試及格


                1988    中華民國免疫病專科醫師考試及格


                1988    中華民國風濕病專科醫師考試及格


[Academic Appointment]


教職             


              1988-1991   國立陽明醫學院臨床講師 (Clinical Lecturer)


                1988-1992   國防醫學院臨床講師


                1991-1996   國立陽明大學內科講師 (Lecturer)


1996-            國立陽明大學內科副教授 (Associated Professor)


2001             慈濟大學醫學院專任副教授


2001             國立嘉義大學理工學院兼任副教授


2002             國立中正大學分子生物研究所兼任副教授


2009.7            慈濟大學醫學院專任教授


2010.7      國立中正大學分子生物研究所兼任教授


 


[Award]    1. New Investigator Award,


The Federation of Immunological Societies of Asia-Oceania, 1996


                 第一屆亞太免疫學會傑出研究人員獎


                


2.    Travel Award, The Federation of Immunological Societies of Asia-Oceania, 1996


 


3.    優良醫師,台中榮民總醫院,1986


 


4.    國科會八十二年度乙種研究獎勵


 


5.    國科會八十四年度甲種研究獎勵


 


6.    中央研究院優秀博士研究生獎暨獎助學金, 1993


 


7.    中央研究院優秀醫師研究獎暨獎助學金, 1998


 


8.    優良醫師,嘉義榮民總醫院,1998


 


9.    優良醫師 慈濟大林醫院, 2002


 


[Membership]


學會會員


              1984    中華醫學會


                1984    中華民國內科醫學會


                1988    中華民國過敏病醫學會


                1988    中華民國風濕病醫學會   


[Major Research Interests]


主要專長及研究


1.    流式細胞儀於細胞生理之研究


2.    僵直性脊椎炎之遺傳調控


3.    自體免疫疾病之神經內分泌分子調控


4.    風濕病基因調控研究


5.   傳統藥物治療自體免疫疾病角色之探討


6.   醫學奈米



Referred paper  (學術期刊論文)



1. Wen-Yao Yin, Ming-Chi Lu, Ming-Che Lee, Su-Chin Liu, Teng-Yi Lin, Ning-Sheng Lai.  A correlation between polyomavirus quantification and genotypes in renal transplantation.  The Am J Surg 2010, 200:53-58


2. Chun-Yu Chen, Ning-Sheng Lai, Jaw-Ji Yang, Hsien-Lu Huang, Wei-Chuan Hung, Chin Li, Ta-Hsien Lin, Hsien-Bin Huang. FLJ23654 encodes a heart protein phosphatase 1-binding protein (Hepp1). Biochem Biophy Research Communication 2010, 391:698-702.


3. Chien-Hsueh Tung, Kuo-Liang Yang, MSc, Su-Qin Liu , Ming-Chi Lu, Kuang-Yung Huang, Ning-Sheng Lai. HLA Class I and Class II Antigens in Ankylosing Spondylitis: Observations in Taiwanese Population and B27 Positive Controls.  Formosan J Rheumatology 2010; 24:8-13


 4. Bao-Bao Hsu, Chien-Hsueh Tung, Ming-Chi Lu, Kuang-Yung Huang, Ning-Sheng Lai. Chylothorax in autoimmune disease: A Case Report. J Formosan Medical Association. Formosan J of Rheumatology 2010; 24:88-90


 


5. Kuo-Chih Tseng, Chin-Kuo Chang, An-Liang Chou, Yu-His Hsieh, Chang-An  , Ning-Sheng Lai. Prognostic effect of human leukocyte antigen class I and class II alleles on chronic hepatitis C patients treated by pegylated nterferon-alfa plus Ribavirin in Taiwan. Hepato-Gastroenterology 2010; 57:456-61


6. Ming Chi Lu, Ning Sheng Lai, Hui Chun Yu, Hsien Bin Haung, Song Chou Hsieh, Chia Li Yu. Anti-Citrullinated Protein Antibodies Bind Surface-Expressed Citrullinated Grp78 on Monocyte/Macrophages and Stimulate Tumor Necrosis Factor α Production. Arthritis and Rheumatism  2010/05;62(5):1213-23


7. Tzung-Yi Tsai, Ning-Sheng Lai, Shu-Hui Kuo, Jui-Kun Chiang. The survey of intention to administer H1NI influenza vaccination and its influence factors among southern Taiwanese middle-ages adults  receiving health examination. Tzu Chi nursing journal 2011; 3:73-82


8. Yu Shan Lin1, Kuang Yung Huang, Tzu Fan Wang, Hsien Iu Huang, Hui Chun Yu, Jia Yi Yen, Shih Hui Hung, Su Qin Liu, Ning Sheng Lai*, Hsien Bin Huang*.


       Immunolocalization of Phostensin in Lymphatic Cells and Tissues. Journal of Histochemistry and Cytochemistry. 2011/08;59(8):741-9


9. Jui Kun Chiang, Ning Sheng Lai, Jiunn Kae Chang, Malcolm Koo. Predicting insulin resistance using the triglyceride-to-high-density lipoprotein cholesterol ratio in Taiwanese adults. cardiovascular diabetology. 2011/10;10:93


10. Bao Bao Hsu, Ning Sheng Lai, Chien Hsueh Tung. Clinical Images : Lacrimal gland and renal involvement in IgG4-related sclerosing disease. Arthritis and Rheumatism. 2011/12; 63(12):3875


11. Der-Yuan Chen, Ning-Sheng Lai, Ling-Ying Lu, Hsiu Cheng Chou, Yi-Hsing Chen, Tsu-Yi Hsieh, Yi-Ming Chen, Joung-Liang Lan. A multicenter open-label phase I/II study to assess the safety, tolerability, and efficacy of three dose levels of TuNEX in patients with rheumatoid arthritis. Journal of the Chinese Medical Association (JCMA). 2011; 74:544-551


12. Ning-Sheng Lai, Chia Li Yu, Wen Yao Yin, Hui Chun Yu, Hsien Bin Huang, Chien Hsueh Tung, Ming-Chi Lu. Combination of nifedipine and subtherapeutic dose of cyclosporine additively suppresses mononuclear cells activation of patients with rheumatoid arthritis and normal individuals via Ca2+-calcineurin nuclear factor of activated T cells pathway. Clin Exp Immunol 2012/01 online.


 


13. Chang CM, Su YC, Lai NS, Huang KY, Chien SH, Chang YH, Lian WC, Hsu TW, Lee CC. The combined effect of individual and neighborhood socioeconomic status on cancer survival rates. PLoS One. 2012;7(8):e44325. Epub 2012 Aug 30


14.  Lu MC, Lai NS, Yin WY, Yu HC, Huang HB, Tung CH, Huang KY, YCL. Anti-citrullinated protein antibodies activated ERK 1/2 and JNK 1/2 mitogen-activated protein kinase via binding to surface-expressed citrullinated GRP 78 on mononuclear cells. J Clin Immunol 2012 Nov 28(Epub ahead of print)


15. Chen YC, u YC, Tsai CC, Lai NS, Fan KS, Liu KC. Subcutaneous phaeohyphomycosis caused by exophiala jeanselmei. J Microbio Immunol Infect. 2012 Jul 27 (Epub ahead of print)


16. Lee MC, Lu MC, Lai NS, Liu SC, Yu HC, Lin TY, Hung SP, Huang HB, Yin WY, Renal dysfunction by BK virus infection is correlated with activated T cell in renal transplantation. J Surg Res, 2012 May 17(Epub ahead of print)


17. Tseng KC, HoYC, Hsieh YH, Lai NS, Wen ZH, Li C, Wu SF. Elevated frequency and function of regulatory T cells in patients with active chronic hepatitis C. J Gastroenterol. 2012 Jul 47(7):823-33.


18.Wang TF, Lai NS, Huang KY, Huang HL, Lu MC, Lin YS, Chen CY, Liu SQ, Lin TH, Huang HB. Identification and characterization of the actin-binding  motif of phostensin. Int J Mol Sci 2012,13, 15967-15982. (equal first  author contribution)


 19. Lai NS et al. Aberrant expression of microRNAs in T cells from patients with ankylosing spondylitis contributes to the immunopathogenesis. Clinical and Experimental Immunology, 2013 Jul;173(1):47-57 [2013/02 online]


20. Lu JL, Lai NS, Lu MC. Decreased microRNA(miR)-145 and increased miR-224 expressin in T cells from patients with systemic lupus erythematosus involved in lupus immunopathogenesis. Clinical and Experimental Immunology.  2013 Jan;171(1):91-9 [2012/09 online]


21. Malcolm Koo, Ning-Sheng Lai, Jui-Kun Chiang. Short duration of sleep is associated with hyperleptinemia in Taiwanese adult.  J Clin Sleep Med 2013; 9(10): 1049-1055


22. Ming-Chi Lu, Wen-Yao Yin, Tzung-Yu Tsai, Malcolm Koo, Ning-Sheng Lai. Increased risk of primary Sjogren’s syndrome in female patients with thyroid disorders: a longitudinal population-base study in Taiwan. PLoS ONE 8(10):e77210. Doi: 10.1371/journal.pone.0077210


23. Targeted delivery of antigenic peptide to the endoplasmic reticulum: application for development of a peptide therapy for ankylosing spondylitis. Hui-Chun Yu, Ming-chi Lu, Chin Li, Hsien-Lu Huang, Kuang-Yung Huang, Su-Qin Liu, Ning-Sheng Lai, Hsien-Bin Huang. PLos ONE 8(10): e77451.doi: 10.1371/journal.pone 0077451 (co-corresponder)


24. Ming-Chi Lu, Chao-Hong Jheng, Tzung-Yi Tsai, Mclcolm Koo, Ning-Sheng Lai. Increased dental visits in patients prior to diagnosis of primary Sjogren syndrome: a population-based study in Taiwan. Rheumatol Int DOI 10.1007/s00296-014-3003-5, 2014


25. Ming-Chi Lu, Wen_Hsung Fa, Tzung-Yi Tsai, Malcolm Koo, Ning-Sheng Lai. Inceased utilization of eye disorder-related ambulatory medical services prior to the diagnosis of Sjogreen syndrome in female patients: a longitudinal population-based study in Taiwan. BMJ Open 2014; 4:e003862. Doi:10:1136/bmiopen-2013-003862


26. Ming-Chi Lu, Shin-Tang Yan, Wen-Yao Yin, Malcolm Koo, Ning-Sheng Lai. Risk of rheumatoid arthritis with type 2 diabetes: A nationwide population-based case-control study. PLoS ONE 9(7):e101528. Doi:10.1371/journal.pone.010528


27. Ning-Sheng Lai, Tzung-Yi Tsai, Malcolm Koo, Kuang-Yung Huang, Chien-Hsueh Tung, ming-Chi Lu. Pattern of ambulatory medical care utilization and rheumatologist consultation predating the diagnosis of systemic lupus erythematosus: a national population-base study. PLos ONE 9(7): e101485. Doi:10.1371/journal.pone.010485


Conference paper (醫學研討會論文)


1. 賴寧生. Dose Titration of Etanercept Using Disease Activity Score (DAS28) in Treatment of Patients with Rheumatoid Arthritis in Taiwan . The 28th Annual meeting of Rheumatology Association, ROC, 2010.


2. 賴寧生 劉素勤 呂明錡 童建學 黃光友 許寶寶. Impact of Inflammation on DNA Methylation in Chinese Patients with Ankylosing Spondylitis-a pilot epigenetic study showed increased methylation of SOCS-1 gene in AS. The 28th Annual meeting of Rheumatology Association, ROC, 2010


3. Lai Ning-Sheng. Dose Titration of Etanercept Using Disease Activity Score (DAS28) in Treatment of Patients with Rheumatoid Arthritis in Taiwan.   2011 symposium of the Asia Pacific League of Association for Rheumatology


4. Lai Ning-Sheng. M Chen.   Impact of Inflammation on DNA Methylation in Chinese Patients with Ankylosing Spondylitis-a preliminary epigenetic study showed increased methylation of SOCS-1 gene in AS.  2011 symposium of the Asia Pacific League of Association for Rheumatology   


5. Lai Ning –Sheng.  Outcome of Rituximab in patients with rheumatoid arthritis with TNF-treatment failure: results from a local hospital experience south Taiwan. 2011 symposium of the Asia Pacific League of Association for Rheumatology


6. Lai ning-Sheng. Epigenetics regulation in autoimmune disease. Invited speech.  


 The 29th Annual meeting of Rheumatology Association, ROC, 2011


7. 許寶寶 呂明錡 童建學 黃光友 賴寧生. Pachydermoperiostosis : A case report and review of the literature. The 29th Annual meeting of Rheumatology Association, ROC, 2011


8.呂明琦Lu MC, 賴寧生Lai NS, 游惠君Yin WY, 余家利YCL. Anti-citrullinated protein antibodies activated ERK 1/2 and JNK 1/2 mitogen-activated protein kinase via binding to surface-expressed citrullinated GRP 78 on mononuclear cells. The 30th Annual meeting of Rheumatology Association, ROC, 2012


9.李淑芳  賴寧生.風濕病患者運動處方. The 30th Annual meeting of Rheumatology Association, ROC, 2012


10.鄭添財  賴寧生.風溼病合併高危險骨鬆症 The 30th Annual meeting of Rheumatology Association, ROC, 2012


11.童建學  賴寧生. 風溼病合併高危險心血管病變. The 30th Annual meeting of Rheumatology Association, ROC, 2012


12.劉素勤 沈麗倩 游惠君 賴寧生.BK poliovirus quantification in immunosuppressed patients in Taiwan. The 30th Annual meeting of Rheumatology Association, ROC, 2012


13.童建學  許寶寶  呂明琦  賴寧生  Urinary tract involvement as a complication of systemic lupus erythematosus with abdominal vasculitis: a case report. The 30th Annual meeting of Rheumatology Association, ROC, 2012


14. 許寶寶  童建學  吳政翰  呂明琦  黃光永  賴寧生  Subacute thyroiditis in a patient with rheumatoid arthritis during treatment with humira. The 30th Annual meeting of Rheumatology Association, ROC, 2012


15.江惠玲  簡雪燕  游惠君  賴寧生  The evaluation of effects of TNF- 1031 promoter polymorphism on the therapeutic response of Enbrel, Humira and Rituximab in patients with rheumatoid arthritis. The 30th Annual meeting of Rheumatology Association, ROC, 2012


16.游惠君 劉素勤 簡雪燕 沈麗倩 劉亮君  賴寧生  The evaluation of effects of TNF- 863 promoter polymorphism on the therapeutic response of Enbrel, Humira and Rituximab in patients with rheumatoid arthritis. The 30th Annual meeting of Rheumatology Association, ROC, 2012


17.劉亮君 簡雪燕 沈麗倩 游惠君 劉素勤 龔永章 江惠玲 賴寧生  The evaluation of effects of TNF- 857 promoter polymorphism on the therapeutic response of Enbrel, Humira and Rituximab in patients with rheumatoid arthritis. The 30th Annual meeting of Rheumatology Association, ROC, 2012


18.簡雪燕 游惠君 龔永章 賴寧生  The evaluation of effects of TNF- 238 promoter polymorphism on the therapeutic response of Enbrel, Humira and Rituximab in patients with rheumatoid arthritis. The 30th Annual meeting of Rheumatology Association, ROC, 2012


19.沈麗倩簡雪燕 游惠君 劉亮君 江惠玲 賴寧生  The evaluation of effects of TNF- 308 promoter polymorphism on the therapeutic response of Enbrel, Humira and Rituximab in patients with rheumatoid arthritis. The 30th Annual meeting of Rheumatology Association, ROC, 2012


20. 許寶寶  童建學  吳政翰  呂明琦  黃光永  賴寧生  A case of rheumatoid arthritis complicated with tocilizumab-induced interstitial pneumonitis The 30th Annual meeting of Rheumatology Association, ROC, 2012


21童建學  呂明琦  許寶寶  賴寧生  High risk of cervical fracture in patients with psoriatic arthropathy- two case report. The 30th Annual meeting of Rheumatology Association, ROC, 2012


22Ming-Chi Lu, Hua-Chien Chen, Chia Li Yu, Ning-Sheng Lai. Aberrant expression of mi RNAs in T cells from patients with Rheumatoid arthritis contributes to the rheumatoid Patogenesis. The 31th Annual meeting of Rheumatology Association, ROC, 2013


23建學, 呂明琦, 黃光永, 許寶寶,賴寧生. Marginal zone lymphoma in a SLE with severe hemolytic anemia. The 31th Annual meeting of Rheumatology Association, ROC, 2013


24童建學, 呂明琦, 黃光永, 許寶寶,賴寧生. Lethal pneumocystis Jirovecii pneumonia in a Behcet’s disease patient treated with TNF blocker.  The 31th Annual meeting of Rheumatology Association, ROC, 2013






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