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20215月份
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最後更新2021/05/14
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::: * 首頁 > 師資陣容new5 > 黃建智副教授

* * 黃建智副教授
*

友善列印

黃建智   教授

一、學歷:

國立清華大學 化學系 學士 (1996)

國立清華大學 化學系博士 (2002)

二、經歷:

2005-2012        財團法人生物技術開發中心研究員

2012-2015        嘉義大學應用化學系 助理教授

2015-               嘉義大學應用化學系 副教授

三、專業領域:

藥物化學、有機化學

四、連絡方式:

  Office: 應化一館305室(A17-305)

     Office Tel: 05-2717959; Lab Tel: 05-2717408; Fax: 05-2717901

  E-mail: lukehuang@mail.ncyu.edu.tw

研究興趣:

        藥物化學、抗癌新藥開發、新有機反應開發

代表性論文:校務系統研究成果

 

1.      Chiang, C.-C.; Lin, Y.-H.; Lin, S. F.; Lai, C.-L.; Liu, C.; Wei, W.-Y.; Yang, S.-c.; Wang, R.-W.; Teng, L.-W.; Chuang, S. H.; Chang, J.-M.; Yuan, T.-T.; Lee, Y.-S.; Chen, P.; Chi, W.-K.; Yang, J.-Y.; Huang, H.-J.; Liao, C.-B.; Huang, J. J.* “Discovery of Pyrrole–Indoline-2-ones as Aurora Kinase Inhibitors with a Different Inhibition Profile,” J. Med. Chem. 2010, 53, 5929–5941.

 

2.      Lin, S. F.; Lin, Y.-H.; Lin, M.; Kao Y.-F.; Wang, R.-W.; Teng, L.-W.; Chuang, S. H.; Chang, J.-M.; Yuan, T.-T.; Fu, K.-C.; Huang, K. P.; Lee, Y.-S.; Chiang, C.-C.; Yang, S.-c.; Lai, C.-L.; Liao, C.-B.; Chen, P.-N.; Lin, Y.-S.; Lai, K.-T.; Huang, H.-J.; Yang, J.-Y.; Liu, C.-W.; Wei, W.-Y.; Chen, C.-K.; Hiipakka, R. A.; Liao, S. Huang, J.-J.* “Synthesis and Structure–Activity Relationship of 3-O-Acylated (–)-Epigallocatechins as 5a-Reductase Inhibitors,” Euro. J. Med. Chem. 2010, 45, 6068–6076.

 

3.      Chang, T.-Y.; Tu, Y.-P.; Wei, W.-Y.; Chen, H. Y.; Chen, C.-S.; Lee, Y.-S. E.; Huang, J.-J.*; Sha, C.-K.* “Synthesis and Antiproliferative Activities of Ottelione A Analogues” ACS Med. Chem. Lett. 2012, 3, 1075–1080.

 

4.      Lee, Y.-S. E.; Chuang, S.-H.; Huang, L. Y. L.; Lai, C.-L.; Lin, Y.-H.; Yang, J.-Y.; Liu, C.-W.; Yang, S.-c.; Lin, H.-S.; Chang, C.-c.; Lai, J.-Y.; Jian, P.-S.; Lam, K.; Chang, J.-M.; Lau, J. Y. N.; Huang, J.-J.* “Discovery of 4-Aryl-N-arylcarbonyl-2-aminothiazoles as Hec1/Nek2 Inhibitors. Part I: Optimization of In Vitro Potencies and Pharmacokinetic Properties,” J. Med. Chem. 2014, 57, 4098–4110.

 

5.      Liu, C.-W.; Lai, C.-L.; Lin, Y.-H.; Teng, L.-W.; Yang, S.-c.; Wei, W.-Y.; Lin, S. F.; Yang, J.-Y.; Huang, H.-J.; Wang, R.-W.; Chiang, C.-C.; Lee, M.-H.; Wang, Y.-C.; Chuang, S. H.; Chang, J.-M.; Yuan, T.-T.; Lee, Y.-S. E.; Huang, J.-J.* “Design and Synthesis of Pyrrole–5-(2,6-Dichlorobenzyl)sulfonylindolin-2-ones with A C-3 Side Chains as Potent Met Kinase Inhibitors,“ RSC Adv. 2014, 4, 58990–58998.

 

6.      Jiann-Jyh Huang* et al. One-flask synthesis of 1,3,5-trisubstituted 1,2,4-triazoles from nitriles and hydrazonoyl chlorides via 1,3-dipolar cycloaddition,” RSC Advances. 2014, 4, 14215–14220.

 

7.      Wang, L.-Y.; Chang, E.-C.; Yeh, M.-Y.; Chung, Y. H.; Huang, J.-J.; Wong, F. F.“ Synthesis of 1,3,4-oxadiazole-based aromatic and heterocyclic/phenylpyrazole derivatives,” Heteroatom Chemistry. 2014, 25, 171–177.

 

8.      31. Huang, L. Y. L.; Chang, C.-C.; Lee, Y.-S.; Huang, J. J.; Chuang, S.-H.; Chang, J.-M.; Kao, K.-J.“Inhibition of Hec1 as a novel approach for treatment of primary liver cancer,” Cancer Chemother. Pharmacol. 2014, 74, 511–520.

 

9.      Huang, L. Y. L.; Chang, C.-C.; Lee, Y.-S.; Chang, J.-M.; Huang, J.-J.; Chuang, S.-H.; Kao, K.-J.; La.Activity of a novel Hec1-targeted anticancer compound against breast cancer cell lines in vitro and in vivo,” Molecular Cancer Therapeutics. 2014, 13, 1419–1430.

 

10.  黃建智.“Vilsmeier–Haack reagent-promoted formyloxylation of a-chloro-N-arylacetamides by formamide,” RSC Advances. 2015, 5, 35934–35939.

 

專利:

  1. Hwu, J.-R.; Tsay, S.-C.; Lu, K.-L.; Huang, J.-J.; Hung, J.-T.; Yu, S.-F. “Organometallic Complex,” Eur. Patent 1,394,169 (B1), April 18, 2007.
  2. Huang, J.-J. et al. “Indolinone Compounds as Kinase Inhibitors,” U.S. Patent 7,897,602; TW201026665 (A).
  3. Lau, J.; Huang, J. J. “Modulators of HEC1 Activity And Methods Therefor,” WO2011115998 (A3); US2011230486 (A1); CA2793311 (A1); AU2011227398 (A1).
  4. Huang, J. J.; Liao, C.-B.; Chen, P. “Quinazoline Compounds as Kinase Inhibitors,” U.S. Patent 8,785,759; TW201326129 (A).
  5. Huang, J. J.; Chuang, S.-H.; Lee, Y.-S. E.; Lau, J.; Huang, Y.-L. “Modulators of Hec1 Activity And Methods Therefor,” 中華民國102099.002TW
  6. Huang, J. J.; Chuang, S.-H.; Lee, Y.-S. E.; Lau, J.; Huang, Y.-L. “Improved Modulators of Hec1 Activity and Methods Therefor,” US Application No. 13/689590; PCT Application No. PCT/US12/67123.
  7. Chen, A.; Ka, S.-M.; Chang, J.-M.; Huang, J.-J. “Use of Epigallocatechin-3-gallate for Immune Regulation,” US20120309821(A); TW201249436A.
  8. Wu, R.-Y.; Chen, H.-L.; Wu, Y.-Y.; Huang, J.-J.; Lee, S.-S.; King, K-L. “GLP-1 Potentiators from Hedychium coronarium and Their Applications,” US2013331323 (A1).

八、研究計畫:國科會

九、教授課目:普通化學,   有機化學,  有機合成,  書報討論,  專題研究,  化學應用概論, 科學與生活


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