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20215月份
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最後更新2021/05/14
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::: * 首頁 > 師資陣容new5 > 黃人則副教授(合聘)

* * 黃人則副教授(合聘)
*

友善列印

黃人則 教授           



Current Position: 

 Associate Research Fellow, Institute of Chemistry, Academia Sinica.

Office Address:

Rm B607, Institute of Chemistry, Academia Sinica, Nangang 115, Taipei, Taiwan

Tel:     02-2789-8652

Fax:    02-2783-1237

E-mail: jthuang@gate.sinica.edu.tw

 

EDUCATION:

 

2000-2004                    National Taiwan University, Taipei, Taiwan

                                      Ph. D. Chemistry, Biophysical Chemistry

1996-1998                    National Tsing Hua University, Hsin-Chu, Taiwan

                                      M. S. Chemistry, Bioorganic Chemistry

1992-1996                    National Tsing Hua University, Hsin-Chu, Taiwan

                                      B. S. Chemistry

 

FIELD OF SPECIALRY:

l  Protein Chemistry

l  Biophysics

l  Biochemistry

 

EMPLOYMENT:

2014-present   Associate Research Fellow

              Institute of Chemistry, Academia Sinica, Taiwan

2007-2013          Assistant Research Fellow

                            Institute of Chemistry, Academia Sinica, Taiwan

2005-2007           Postdoctoral Research Associate    

                            Department of Chemistry, University of Wisconsin-Madison, USA

2004-2005           Postdoctoral Fellow                                                                     

                            Institute of Chemistry, Academia Sinica, Taiwan

 

RESEARCH INTEREST:

 

1.       Explore the process of co-translational protein folding and the roles of chaperones.

2.       The normal function of TDP-43 and its role in Amyotrophic Lateral Sclerosis (ALS).

3.       The characterization of the aggregation process of TDP-43 and Huntingtin (Htt) in Amyotrophic Lateral Sclerosis (ALS) and Huntington’s disease (HD).

4.       The development of therapeutic strategies against neurodegenerative diseases.

 

HONORS AND AWARDS:

 

Awards:

2012             Excellent Young Scholar Award

Award received from the Chemical Society Located in Taipei

2012             「科學大師」系列講座講師

Award received in Taipei Municipal University of Education

2005-2007    Taiwan Merit Scholarship

Join program of Taiwan’s Ministry of Education, Council for Economic Planning and Development, and National Science Council.

2004             Best Ph. D. Thesis

Award received from the dean of the Science School, National Taiwan University.

2004             Ph. D. Thesis Excellent Poster Presentation

Award received in Department of Chemistry, National Taiwan University.

2002             The First Place of Poster Competition

                     Award received in the 8th Symposium of Biophysical Society in Taiwan.

1997             Li-Ching Graduate Thesis Scholarship

                     Award received from Li-Ching Foundation, Taiwan.

1994             Taoyuan County Government Scholarship

                     Award received from Taoyuan County Government, Taiwan.

1993             Mr. Jung Ya Wu Educational Scholarship

                     Award received from Jung Ya Wu Foundation, Taiwan.

 

Advisor of Student Awards:

 

2014             Poster Competition Award

                     Award received from the 19th Biophysical Conference, Advisor of the 1st prize

2013             Oral Competition Award

Award received in 10th TIGP-Molecular Medicine (TIGP-MM) Retreat, 1st Prize

2012             Dissertation award

Award received in Department of Chemistry, National Taiwan University, Advisor of Excellence Award

2012             Poster Competition Award

Award received from the 17th Biophysics Conference, Advisor of the 2nd Prize

2011             Dissertation award

Award received from the Chemical Society Located in Taipei, Advisor of Honorable Mentions

2010             Dissertation award

Award received from the Chemical Society Located in Taipei, Advisor of Excellence Award

Invited Lectures:

                     (International Symposium)

2016             KAUST-NTU-AS Workshop for Enhancing collaborations on Research and Education in Chemical and Materials Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia

2015             2015-Advances in Peptide and Protein Chemistry: International Chemical Congress of Pacific Basin Societies, Honolulu, Hawaii, USA

2015             分子科學前沿海峽兩岸交流會/中國科學院化學研究所/北京/中國

2014             The 2nd Taiwan-Tohoku University Neuroscience Workshop for Young Scientists : The Brain in Function and Malfunction: a Naurogenetic Approach, The Miyagi-Zao Royal Hotel and Tohoku University, Miyagi, Japan

2014             International Symposium on Nanomedicine Molecular Science, Nagoya University Hospital, Nagoya, Japan

2013             Institute for Protein Research Seminar 2013, Osaka, Japan

2013             2013 Academia Sinica and UC Davis Neuroscience Symposium, University of California, San Francisco, USA

2011                                           The 11th Tateshina Conference on Organic Chemistry, Nagoya, Japan

2011                                           The 1st International Kyoto Conference on Organic Nanostructures, Kyoto University, Kyoto, Japan

2010             Pacifichem 2010 Symposium, Hawaii, USA

 

                     (Domestic Symposium)

2015             2015-Annual Meeting of Chinese Chemical Society, National Dong Hwa University, Hualien

2015             2015 Taipei International Workshop for Soft Matter and Biophysics, Astronomy-Mathematics Building, National Taiwan University, Taipei, Taiwan

2015            The 6th Taiwan-Japan Symposium on Nanomedicine, Academia Sinica, Taipei, Taiwan

2014             2014 TIGP-NCKU Interdisciplinary Neuroscience Retreat, Tainan, Tainan

2013             2013 The Hebrew University of Jerusalem, Israel - Academia Sinica Bilateral Workshop on Nanoscience and Nanotechnology

2013             2013 Technologies for Medical Diagnosis Therapy Symposium, Academia Sinica, Taiwan

2012                                           17th Symposium of Biophysical Society in Taiwan, Academia Sinica, Taiwan

2012                                           Frontiers in Chemistry-A symposium dedicated to the memory of Prof. Ta-shue Chou, Academia Sinica

2011                                           2011-Annual Meeting of Chemical Society, National Tsing-Hua University, Hsinchu

2011                                           16th Symposium of Biophysical Society in Taiwan, Hua Lien, Taiwan

2010                                           2010 Annual meeting of Chinese Chemical Society, Taipei, Taiwan

2009             Frontier of protein aggregation and neurodegenerative disease Symposium, Academia Sinica, Taipei, Taiwan

 

                     (Others)

2012                                           The different faces of intrinsically disordered domains of TDP-43 in Amyotrophic Lateral Sclerosis/Taipei Municipal University of Education

2011             Light up the folding zone within the ribosome tunnel/Sunney Chan Symposium/Academia Sinica, Taiwan

2011         Structural and functional characterization of TDR-DNA binding protein (TDP-43) in Amyotrophic Lateral Sclerosis/National Tsing Hua University

2011             The impact of co-translational protein folding within the ribosome tunnel on chaperone recruitment/ National Dong-Hwa University

2010             Protein misfolding in neuron degenerative disease/National Chia-Yi University

2010         Dance with Chemistry and Biology-From protein misfolding to the new therapeutic strategy against neurodegenerative diseases/National Taiwan University

2010             From TAR-DNA binding protein to Neuron Degenerative Disease/National Taiwan Normal University

2008             Novel biophysical approach to protein folding studies/National Tsing-Hua University

2008             Ultrafast and cotranslational protein folding studies/National Chiao-Tung University

 

 

JOURNAL REFEREE:

                   

Acta Biomaterialia

BBA - Molecular Basis of Disease

Biochemistry

Journal of Neurochemistry

Journal of Biological Chemistry

International Journal of Immunopathology and Pharmacology

Journal of the Chinese Chemical Society

 

List of Research Publications:

 

JOURNAL ARTICLES:

1.         He, R.-Y.; Huang, Y.-C.; Chiang, C.-W.; Tsai, Y.-J.; Ye, T.-J.; Gao, H.-D.; Wu, C.-Y.; Lee, Y.-M.; Huang, J. J.-T.* Characterization and real-time imaging of the FTLD-related protein aggregation induced by amyloidogenic peptides. Chem. Commun. 201551, 8652. (IF: 6.8, ▲: 1)

2.         Sun, C.-S. ; Lee, C.-C.; Li, Y-N; Yang S. Y.-C.; Lin, C.-H.; Chang, Y.-C.; He, R.-Y.; Liu, P.-F.; Wang ,C.-H.; Chen, W.; Chern, Y.*; Huang J. J.-T.* Conformational switch of polyglutamine expanded huntingtin into benign aggregates leads to neuroprotective effect. Sci. Rep. 20155, 14992. (IF: 5.6, ▲: 1)

3.         Koubek, J.; Chen, Y.-R.; Cheng, R.-P.; Huang, J. J.-T.* Nonorthogonal tRNAcysAmber for protein and nascent chain labeling. RNA 201521, 1672. (IF: 4.9)

4.         Sun, C.-S.Wang, C. Y.-H.Chen, B.-W.He, R.-Y.Wang, C.-H.Chen, W.Chern, Y.Huang, J. J.-T.* The influence of mutations and proline substitutions in TDP-43 C-terminal peptides on its amyloid properties and cellular toxicity. PLoS ONE 2014, 9(8), e103644 (IF: 3.7, ▲: 6)

5.         Huang , C.-C.Bose J.-K.Majumder P.Lee K.-H.Huang, J. J.-T.Huang J. K.Shen J. C.-K.* Metabolism and mis-metabolism of the neuropathological signature protein TDP-43. J. Cell Sci. 2014, 127, 3024-3038  (IF: 5.9, ▲: 11)

6.         Liu, G. C.-H.Chen, B. P.-W.Ye, N. T.-J.Wang, C.-H.Chen, W.Lee, H.-M.Chan, S. I.Huang, J. J.-T.* Delineating the membrane-disrupting and seeding properties of the TDP-43 amyloidogenic core. Chem. Commun. 2013, 49,11212-11214. (IF: 6.8, ▲: 5)

 (Highlighted in Significant Research Achievements of Academia Sinica 2013)

7.         Koubek, J.Lin, K.-F.Chen, Y.-R.Cheng, R.-P.*Huang, J. J.-T.* Strong anion exchange fast performance liquid chromatography as a versatile tool for preparation and purification of RNA produced by in vitro transcription. RNA 2013, 19,1449-1459 (IF: 5.088, ▲: 12)

8.         Huang, Y.-C.Lin, K.-FHe, R.-Y.Tu, P.-H.Koubek, J.Hsu, Y.-C.Huang, J. J.-T.* Inhibition of TDP-43 aggregation by nucleic acid binding. PLoS One 2013, 8(5), e64002  (IF: 3.73, ▲: 11)

9.         Chang, C.-K.Wu, T.-H.Wu, C.-Y.Chiang, M.-H.Toh, E.-K.Hsu, Y.-C.Lin, K.-F. Liao, Y.-H.Huang, T.-H.*Huang, J. J.-T.* The N-terminus of TDP-43 promotes its oligomerization and enhances DNA binding affinity. Biochem. Biophys. Res. Commun. 2012, 425, 219-224  (IF: 2.406, ▲: 14)

10.     Lin, K.-F.Sun, C.-S.Huang, Y.-C.Chan, S.-I.Koubek, J.Wu, T.-H.Huang, J. J.-T.* Cotranslational Protein Folding within the Ribosome Tunnel Influences Trigger-Factor Recruitment. Biophys. J. 2012, 102, 2818-2827. (IF: 3.832, ▲:16)

11.     Huang, J. J.-T.; Larsen, R.-W.; Chan, S.-I.* The Interplay of Turn Formation and Hydrophobic Interactions on the Early Kinetic Events in Protein Folding. Chem. Commun. 2012, (Feature Article), 48, 487-497.(IF: 6.718, ▲:7)

12.     Chen, K.-H.; Lin, Y.-Y.; Xie, Z.-J.; Tu, P.-H.; Chen, P.-Y.; Liao, T.-Y.; Chen, W.; Wang, C.-H.; Huang, J. J.-T.* Induction of Amyloid Fibrils by the C-Terminal Fragments of TDP-43 in Amyotrophic Lateral Sclerosis. J. Am. Chem. Soc. 2010, 132, 1186-1187. (IF: 11.4, ▲:49) (Highlighted in Significant Research Achievements of Academia Sinica 2010) (Selected in 2010 Science and Technology Yearbook of Republic of China)

13.     Hwu, J. R.*; Huang, J. J.-T.; Tsai, F.-Y.; Tsay, S.-C.; Hsu, M.-H.; Hwang, K. C.; Horng, J.-C.; Ho, J. A.; Lin, C.-C. Photochemical activities of N-nitroso carboxamides and sulfoximides as well as their application to DNA cleavage. Chem. Eur. J. 2009, 15, 8742-8750. (Cover Article) (IF: 5.93, ▲:5)

14.     Huang, J. J.-T.*; Jhan, J.-W. Ultra-fast and Cotranslational Protein Folding. Natural Sciences Newsletter. 2008, 20, 50-53.

15.     Kirchdoerfer, R. N.; Huang, J. J.-T.; Isola, M. K.; Cavagnero, Silvia.* Fluorescence-Based Analysis of Aminoacyl- and Petidyl-tRNA by Low-pH SDS PAGE. Anal. Biochem. 2007, 364, 92-94. (IF: 3.247, ▲:11)

16.     Kuo, N. N.-W.; Huang, J. J.-T.; Miksovska, J.; Chen, P.-Y.; Larsen, R.; Chan, S.I.* Effects of turn stability on the kinetics of refolding of a hairpin in β-sheet. J. Am. Chem. Soc. 2005, 127, 48, 16945-16954. (IF: 10.678, ▲:16)

17.     Chen, R. P. Y.; Huang, J. J.-T.; Chen, H. L.; Jan, H.; Velusamy, M.; Lee, C. T.; Fann, W. S.; Larsen, R. W.; Chan, S. I.* Measuring the refolding of beta-sheets with different turn sequences on a nanosecond time scale. Proc. Natl. Acad. Sci. U. S. A. 2004, 101, 7305-7310. (IF: 9.737, ▲:56)

 

BOOK CHAPTER:

1.   Chan, S. I. *; Huang, J. J.-T.; Larsen, R. W.; Rock, R. S.; Hansen, K. C. Early kinetic events in protein folding: The development and applications of caged peptides in Dynamic Studies in Biology; Goeldner, M. and Givens. R. (eds), Wiley-VCH GmbH & Co. Germany, 2005, pp 479-494.

 

POPULAR SCIENCE IN CHINESE:

2.   Protein Folding: The journey from ribosome to cellular function (Academia Sinica Newsletter 2012, 1364, 5-8)

蛋白質摺疊:從核醣體到細胞功能的旅程(中央研究院週報20121364-知識天地專刊)

3.   Unfreeze Amyotrophic Lateral Sclerosis, Special topics from Neuroscience Program in Academia Sinica (NPAS) (Scientific American-Chinese version 2012, 107, 7-10)

解凍漸凍人(科學人雜誌2011107-中央研究院挑戰卓越系列-跨領域攜手合作,揭開神經疾病的奧秘)

 

PATENT AND TECHNOLOGY TRANSFER

4.   Tu P-H, Chen P-Y, Huang J-T, Chern Y, Jang Y-S. Bipartite Molecules and Uses Thereof in Treating Diseases Associated with Abnormal Protein Aggregates, Attorney Docket No.: A0988.70055US00, Client Reference No.: 12A-1021120.

 

 

Grant Review:

n   Medical Research Council (United Kingdom)

n   National Science Council Grants, Taiwan

 

 

Invited Talks:

2015       2015-Advances in Peptide and Protein Chemistry: International Chemical Congress of Pacific Basin Societies/Honolulu, Hawaii, USA

2015   分子科學前沿海峽兩岸交流會/中國科學院化學研究所/北京/中國

2015    2015-Annual Meeting of Chinese Chemical Society, National Dong Hwa University/ Hualien

2014         淺談化學 (化學和生物共舞)/ 中央研究院2014院慶演講

2014         TIGP-INS program orientation talk

2013         Institute for Protein Research Seminar 2013/Osaka, Japan

2013         2013 Academia Sinica and UC Davis Neuroscience Symposium, University of California/San Francisco, USA

2012         17th Symposium of Biophysical Society in Taiwan/Academia Sinica, Taiwan

2012         Frontiers in Chemistry-A symposium dedicated to the memory of Prof. Ta-shue Chou/Academia Sinica

2012     The different faces of intrinsically disordered domains of TDP-43 in Amyotrophic Lateral Sclerosis/ Taipei Municipal University of Education

2011         2011-Annual Meeting of Chemical Society/National Tsing Hua University, Hsinchu

2011         11th Tateshina Conference on Organic Chemistry/Nagoya, Japan

2011         The 1st International Kyoto Conference on Organic Nanostructures/Kyoto University, Kyoto, Japan

2011         16th Symposium of Biophysical Society in Taiwan/Hua Lien, Taiwan

2011         Sunney Chan Symposium/Academia Sinica, Taiwan

2011     Structural and functional characterization of TDR-DNA binding protein (TDP-43) in Amyotrophic Lateral Sclerosis/ National Tsing Hua University

2011     Application of Protein Engineering and Evolution to Bio-Industry/Academia Sinica                                                                  

2011         The impact of co-translational protein folding within the ribosome tunnel on chaperone recruitment/ National Dong-Hwa University

2010         Protein misfolding in neuron degenerative disease/ National Chia-Yi University

2010     Dance with Chemistry and Biology-From protein misfolding to the new therapeutic strategy against neurodegenerative diseases /National Taiwan University

2010         From TAR-DNA binding protein to Neuron Degenerative Disease/National Taiwan Normal University

2010         Pacifichem Symposium/Hawaii, USA

2010     Annual meeting of Chinese Chemical Society/Taipei, Taiwan

2009         The Induction of TDP-43 C-terminal Fragment into Amyloid Fibrils by G294A Mutation in Amyotrophic Lateral Sclerosis/ Frontier of Protein Aggregation and Neurodegenerative Diseases

2008         Novel biophysical approach to protein folding studies/ National Tsing-Hua University

2008          Ultrafast and cotranslational protein folding studies/ National Chiao-Tung University

2008          淺談化學 (化學和生物的圓舞曲:可樂的化學與水母的螢光)/ 中央研究院2008院慶演講

 

ORGANIZED SYMPOSIUMS:

 

1.     2015-Advances in Peptide and Protein Chemistry/2015-12-15~2015-12-20/ International Chemical Congress of Pacific Basin Societies, Honolulu, Hawaii, USA (Co-organizer and Section chair).

 

2.     2013-Biophysics Conference/2013-6-27~2013-6-29/ Institute of Biomedical Sciences, Academia Sinica (Co-organizer and Section chair)

 

3.     2010-Sunney Chan Lecture /2010-11-26 /Institute of Chemistry, Academia Sinica (Co-Organizer)

 

4.     Frontier of Protein Aggregation and Neurodegenerative Diseases/ 2009-06-04~2009-06-05/ Institute of Chemistry/ Institute of Biochemistry/ Institute of Biomedical Chemistry/ Genomics Research Center/ Institute of Cellular and Organismic Biology/Institute of Molecular Biology (Co-organizer and Section chair)

 

SERVICE AND TEACHING

 

Service

1.         Instrumentation committee members in Academia Sinica

2.         Qualify exam committee members in TIGP-CBMB program, Academia Sinica (2011-)

3.         Dormitory committee members in Academia Sinica (2008-)

4.         Core members in Neuron Science Program in Academia Sinica (NPAS)(2008-2012)

5.         BioPhysics instrumentation user committee members in Academia Sinica (2011-)

6.         Academic committee members in Institute of Chemistry, Academia Sinica (2007-)

7.         Instrumentation committee members in Institute of Chemistry, Academia Sinica (2011-)

8.         Library committee member in Institute of Chemistry, Academia Sinica (2007-)

9.         Adjunct professor in Department of Chemistry, National Central University

10.     Adjunct professor in Department of Chemical Engineering, National Taiwan University of Science and Technology (2010-)

11.     Adjunct professor in National Defense Medical Center (2010-)

12.     Adjunct professor in Taipei Municipal University of Education (2012-)

13.     Academic committee members in Institute of Chemistry, Academia Sinica (2013-)

 

Teaching

1.         Experimental Molecular Biophysics, TIGP-CBMB program, Academia Sinica (2014) (three lectures)

2.         Biochemistry, National Central University (2008-2009) (five lectures)

3.         Seminar coordinator, National Central University (2008)

4.         Fundamental Chemical Biology and Molecular Biophysics, TIGP-CBMB program, Academia Sinica (2009-2010)(three lectures)

5.         The Chemical Biology of Protein Science, National Taiwan University (2010)(two lectures)

6.         Application of Protein Engineering and Evolution to Bio-Industry, TIGP-MBAS program, Academia Sinica (2010-2011)(three lectures)

7.         Special Topics in Chemical Biology, National Central University (2011)(five lectures)

8.         Seminar, TIGP-CBMB program, Academia Sinica (2013)

9.         Modern Spectroscopy in Chemistry, Institute of Chemistry, Academia Sinica (2013)(one lecture)

10.     Advances in Chemical Biology, National Central University (2013)(six lectures)

11.     Special Topics in Chemical Biology, National Central University (2013)(six lectures)

12.     Biomolecular Analysis and Engineering, TIGP-MBAS program, Academia Sinica (2013)(two lectures)

 

POSTER PRESENTATION:

2016          A Simple Way to Determine Stoichiometry of Protein-DNA/RNA Interaction nd the binding mode of TDP-43 RNA Recognition Domains

2015          Synthetic Q/N-rich Polypeptides from TDP-43 Exhibit Amyloidogenic Properties and Induce the Cytoplasmic Aggregation by Microinjection/2015 Annual Meeting of Chemical Society Located in Taipei

2015          Early recognition by SecA targets secretory protein near the ribosome exit tunnel/ Protein synthesis and translational control/Germany

2015        The local and global effects of DnaK and Trigger Factor on ribosome-bound nascent chain dynamics/ Molecular chaperones: From molecules to cells and misfolding diseases/ Greece

2014          The amyloid and prion-like properties of the TDP-43 peptides in Amyotrophic Lateal Sclerosis/ The 2nd Taiwan-Tohoku University Neuroscience Workshop for Young Scientists/ Japan

2014          Synthetic Gluntamine/Asparagine-rich polypeptides from TDP-43 exhibit amyloid properties and induce prion-like aggregation in amyotrophic lateral scelerosis/ The 2nd Taiwan-Tohoku University Neuroscience Workshop for Young Scientists/ Japan

2014          Development of cysteine-specific tRNA and tRNA synthetase for site-specific protein fluorescence labeling in co-translational protein folding studies/25th tRNA Conference/ Greece

2014          Delineating the membrane-disrupting and seeding properties of the TDP-43 amyloidogenic core/ The 19th Biophysics Conference

2014          The modulation of FKBP12 on the mutant Huntintin-induced neurotoxicity and aggregation/ The 19th Biophysics Conference    

2013     Modulate polyglutamine protein aggregation by Trigger factor and FKBP12/ NPAS Summer student discussion

2013          Characterization of the aggregation properties of amyloid core in the TDP-43 C-terminal fragments/ NPAS Summer student discussion

2013     C-terminal aggregation-prone domain of neurodegenerative TDP-43 is required for altering ssDNA/RNA structure/ The 18th Biophysics Conference

2013     Characterization of the thermal induced fiber from TDP-43 and its association with single-stranded DNA/ The 18th Biophysics Conference

2013     Inhibition of TDP-43 aggregation by nucleic acid binding/ The 18th Biophysics Conference

2013     Directional binding of nucleic acid to TAR DNA-binding protein (TDP-43) RRM1 domain provides insight into splicing regulation/ The 18th Biophysics Conference

2013     Structure characterization of ATPase-chaperone-preprotein recognition in the secretory pathway/ The 18th Biophysics Conference

2013     Modulate polyglutamin protein aggregation by Trigger factor and FKBP12/ The 18th Biophysics Conference

2012     The influence of molecular chaperones on the mHtt protein aggregation process/2012 Annual Meeting of Chemical Society

2012          Co-translational Protein Folding: The Journey from the Ribosome Tunnel to Cellular Function/The 12th Annual Meeting of the Protein Science Society of Japan

2012          The roles of TDP-43 associated oligonucleotides on its aggregation process/The 12th Annual Meeting of the Protein Science Society of Japan

2012          Characterization of the aggregation properties of amyloid core in the TDP-43 C-terminal fragments/The 17th Biophysics Conference

2012          The impact of mutations in TDP-43 fragments on the formation of amyloid fibers and cellular toxicity/The 17th Biophysics Conference

2012          Co-translational protein folding within the ribosome tunnel influences trigger-factor recruitment/The 17th Biophysics Conference

2012          Observing the oligomerization in living cell model of Huntington’s disease by advanced time-lapse microscopy/NPAS-NCKU Neuroscience Retreat.

2011          Characterize the aggregation process of the mHtt protein in the presence of chaperone/France-Taiwanese Symposium on Neurobiology, IGBMC

2011                                   The Discovery of the Amyloid Fibrils from the C-terminal Fragments of TDP-43 in Amyotrophic Lateral Sclerosis/The 11th Tateshina Conference on Organic Chemistry , Nagoya, Japan

2011     Study the aggregation properties of TDP-43 in the presence of chaperone and DNA/ The 16th Biophysics Conference

2011     Explore the conformational change and DNA binding mode of TDP-43/The 16th Biophysics Conference

2011     Characterize the biophysical and chemical properties of TDP-43 in ALS/The 16th Biophysics Conference

2011     Characterization of the C-terminal Fragments of TDP-43 in Amyotrophic Lateral Sclerosis/The 16th Biophysics Conference

2010    Identify the specific conformation of the C-terminal Fragments of TDP-43 in Amyotrophic Lateral Sclerosis /NeuroTalk-2010 Conference

2009                                   Study on Cotranslational Protein Folding within the Ribosomal Exit Tunnel/Joint International Conference of Biophysics and 14th Annual Conference of the Biophysical Society of ROC

2009                Mutation in TDP-43 C-terminal Fragment can Induce Beta-Amyloid Fibril Formation/Joint International Conference of Biophysics and 14th Annual Conference of the Biophysical Society of ROC



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