張耿瑞副教授--國立嘉義大學獸醫學系

教師姓名：張耿瑞

現　　職：副教授

學　　歷：

國立中興大學獸醫學系學士 (1997-2002)

國立中興大學獸醫學研究所碩士 (2002-2004)

國立中興大學獸醫學研究所博士 (2004- 2009)

Name：Geng-Ruei Chang

E-mail：grchang@mail.ncyu.edu.tw

TEL ：05-2732946

FAX ：05-2732917

簡要經歷：

國立嘉義大學獸醫學系副教授 (2018/8-現職)

國立嘉義大學獸醫學系助理教授 (2016/8-2018/7)

日本北海道大學獸醫學系獸醫環境科學講座毒理學研究室訪問學者 (2013/8 – 2013/9)

行政院農業委員會農業藥物毒物試驗所助理研究員(2010/11 – 2016/7)

苗栗縣政府農業處公職獸醫師 (2005/9 – 2010/11)

台中市動物保護防疫所公職獸醫師 (2005/8)

國家考試及格：

91年專門職業及技術人員考試獸醫師類科

92年台灣省基層公務人員特種考試三級公職獸醫師類科(中區)

94年公務人員高等考試三級公職獸醫師類科

專長：

動物藥理學、動物生理學、人類疾病動物模式研究、分析毒理學、食品安全研究

研究興趣：

代謝症候群之藥物和分子調控機制、人類免疫抑制和腫瘤之實驗動物模式、野生動物繁殖內分泌生理學、動物基質中藥物及毒物殘留分析檢測、中獸藥之基礎研究及應用

主要教授課程：

獸醫藥理學、實驗動物學、獸醫中藥學、中獸醫方劑學

最近5年參與的研究計畫案：

計畫擔任工作

委託單位

執行期限

計畫名稱

主持人

科技部

107/08/01-108/07/31

調查國內水產物中環境荷爾蒙殘留量和國人食用之風險評估

主持人

農委會

108/01/01-108/12/31

畜禽藥物殘留風險評估管理計畫

主持人

農委會

108/01/01-108/12/31

動物用藥生體可用率及生體相等性先期試驗評估

共同主持人

農委會

108/01/01-108/12/31

新增水產用藥磺胺一甲氧嘧啶與歐美德普複方(Sulfamonomethoxine/Ormetoprim)研究計畫

共同主持人

農委會

108/01/01-108/12/31

養殖烏魚重要疾病監測及防治技術研究

主持人

農委會

109/01/01-109/12/31

畜禽藥物殘留風險評估管理

主持人

農委會

109/01/01-109/12/31

動物用藥生體可用率及生體相等性先期試驗評估

主持人

農委會

110/01/01-110/12/31

畜禽藥物殘留風險評估管理

主持人

農委會

110/01/01-110/12/31

動物用藥生體可用率及生體相等性先期試驗評估

共同主持人

農委會

110/01/01-110/12/31

新增水產用藥磺胺嘧啶與三甲氧芐氨嘧啶複方研究計畫

1. (A)期刊論文:

1. Chang GR, Hou PH, Wang CM, Lin JW, Lin WL, Lin TC, Liao HJ, Chan CH, Wang YC. Imipramine accelerates nonalcoholic fatty liver disease, renal impairment, diabetic retinopathy, insulin resistance and urinary chromium loss in obese mice. Veterinary Sciences 2021; 8: 189. (SCI; Veterinary Sciences: Rank Factor = 35/146, 23.9%; IF = 2.304)

2. Wang JH, Chang CP, Chang CC, Wang CM, Lin CF, Lin JW, Lin WL, Liao HY, Kao CY, Fan PS, Yang WC, Chang GR. Analysis of persistent organochlorine pesticides in shellfish and their risk assessment from aquafarms in Taiwan. Marine Pollution Bulletin 2021; 172: 112811. (SCI; MARINE & FRESHWATER BIOLOGY: Rank Factor = 3/110, 2.7%; IF = 5.553)

3. Chang GR, Kuo CY, Tsai MY, Lin WL, Lin TC, Liao HJ, Chen CH, Wang YC. Anti-cancer effects of zotarolimus combined with 5-fluorouracil treatment in HCT-116 colorectal cancer-bearing BALB/c nude mice. Molecules 2021; 26: 4683. (SCI; CHEMISTRY, MULTIDISCIPLINARY: Rank Factor = 63/179, 35.2%; IF = 4.411)

4. Chang GR, Hsieh WT, Chou LS, Lin CS, Wu CF, Lin JW, Lin WL, Lin TC, Liao HJ, Kao CY Lin CF. Curcumin improved glucose intolerance, renal injury, and nonalcoholic fatty liver disease and decreased chromium loss through urine in obese mice. Processes 2021; 9: 1132. (SCI; ENGINEERING & CHEMICAL: Rank Factor = 68/156, 43.6%; IF = 2.847)

5. Chang GR, Liu HY, Yang WC, Wang CM, Wu CF, Lin JW, Lin WL, Wang YC, Lin TC, Liao HJ, Hou PH, Chan CH, Lin CF. Clozapine worsens glucose intolerance, nonalcoholic fatty liver disease, kidney damage and retinal injury and increases renal reactive oxygen species production and chromium loss in obese mice. International Journal of Molecular Sciences 2021; 22: 6680. (SCI; BIOCHEMISTRY & MOLECULAR BIOLOGY: Rank Factor = 67/298, 22.5%; IF = 5.923)

6. Wu CF, Wu CY, Chiou RYY, Yang WC, Lin CF, Wang CM, Hou PH, Lin TC, Kuo CY, Chang GR. The anti-cancer effects of a zotarolimus and 5-fluorouracil combination treatment on A549 cell-derived tumors in BALB/c nude mice. International Journal of Molecular Sciences 2021; 22: 4562. (SCI; BIOCHEMISTRY & MOLECULAR BIOLOGY: Rank Factor = 67/298, 22.5%; IF = 5.923)

7. Tsai MY, Yang WC, Lin CF, Wang CM, Liu HY, Lin CS, Lin JW, Lin WL, Lin TC, Fan PS, Hung KH, Lu YW, Chang GR. The ameliorative effects of fucoidan in thioacetaide-induced liver injury in mice. Molecules 2021; 26: 1937. (SCI; CHEMISTRY, MULTIDISCIPLINARY: Rank Factor = 63/179, 35.2%; IF = 4.411)

8. Chang GR, Hou PH, Yang WC, Wang CM, Fan PS, Liao HJ, Chen TP. Doxepin exacerbates renal damage, glucose intolerance, nonalcoholic fatty liver disease and urinary chromium loss in obese mice. Pharmaceuticals 2021; 14: 267. (SCI; PHARMACOLOGY & PHARMACY: Rank Factor = 37/275, 13.5%; IF = 5.863; first author and corresponding author)

9. Chang GR, Hou PH, Wang CM, Wu CF, Su HK, Liao HJ, Chen TP. Chronic everolimus treatment of high fat diet mice leads to a reduction in obesity but impaired glucose tolerance. Pharmacology Research & Perspectives 2021; 9: e00732. (SCI; PHARMACOLOGY & PHARMACY: Rank Factor = 174/275, 63.3%; IF = 2.794; first author and corresponding author)

10. Tsai HP, Hou PH, Mao FC, Chang CC, Yang WC, Wu CF, Liao HJ, Lin TC, Chou LS, Hsiao LW, Chang GR. Risperidone exacerbates glucose intolerance, nonalcoholic fatty liver disease, and renal impairment in obese mice. International Journal of Molecular Sciences 2021; 22: 49. (SCI; BIOCHEMISTRY & MOLECULAR BIOLOGY: Rank Factor =67/298, 22.5%; IF = 5.923)

11. Hseu YC, Chiang YC, Gowrisankar YV, Lin KY, Huang ST, Shrestha S, Chang GR, Yang HL. The in vitro and in vivo anticancer properties of chalcone flavokawain b through induction of ros-mediated apoptotic and autophagic cell death in human melanoma cells. Cancers. 2020; 12: 2936. (SCI; ONCOLOGY; Rank Factor = 51/242, 21.1%; IF = 6.639; corresponding author)

12. Wu CF, Hou PH, Mao FC, Su YC, Wu CY, Yang WC, Lin CS, Tsai HP, Liao HY, Chang GR. Mirtazapine reduces adipocyte hypertrophy and increases glucose transporter expression in obese mice. Animals 2020; 10: 1423. (SCI; VETERINARY SCIENCES: Rank Factor = 19/146, 13.0%; IF = 2.752)

13. Wu CF, Chen CH, Wu CY, Lin CS, Su YC, Wu CF, Tsai HP, Fan PS, Yeh CH, Yang WC, Chang GR. Quinolone and organophosphorus insecticide residues in bivalves and their associated risks in Taiwan. Molecules 2020; 25: 3636. (SCI; CHEMISTRY, MULTIDISCIPLINARY: Rank Factor = 63/179, 35.2%; IF = 4.411)

14. Chang GR, Hou PH, Chen WK, Lin CT, Tsai HP, Mao FC. Exercise affects blood glucose levels and tissue chromium distribution in high-fat diet-fed C57BL6 mice. Molecules 2020; 25: 1658. (SCI; CHEMISTRY, MULTIDISCIPLINARY: Rank Factor = 63/179, 35.2%; IF = 4.411)

15. Chang CP, Hou PH, Yang WC, Wu CF, Chang CC, Tsai MY, Tsai HP, Lin CT, Xue YJ, Wang JH, Chang GR. Analytical detection of sulfonamides and organophosphorus insecticide residues in fish in Taiwan. Molecules 2020; 25: 1501. (SCI; CHEMISTRY, MULTIDISCIPLINARY: Rank Factor = 63/179, 35.2%; IF = 4.411)

16. Tsai MY, Ho CH, Chang HY, Yang WC, Lin CF, Lin CT, Xue YJ, Lai JM, Wang JH, Chang GR. Analysis of pollution of phthalates in pork and chicken in Taiwan using liquid chromatography-tandem mass spectrometry and assessment of health risk. Molecules 2019; 24: 3817. (SCI; CHEMISTRY, MULTIDISCIPLINARY: Rank Factor = 63/179, 35.2%; IF = 4.411)

17. Tsai MY, Lin CF, Yang WC, Lin CT, Hung KH, Chang GR. Health risk assessment of banned veterinary drugs and quinolone residues in shrimp through liquid chromatography–tandem mass spectrometry. Applied Sciences 2019; 9: 2463. (SCI; CHEMISTRY, MULTIDISCIPLINARY: Rank Factor = 82/216, 38.0%; IF = 2.679)

18. Chang HY, Yang WC, Xue YJ, Tsai MY, Wang JH, Chang GR. Phthalates and organophosphorus insecticide residues in shrimp determined by liquid/gas chromatography–tandem mass spectrometry and a health risk assessment. Marine Pollution Bulletin 2019; 144: 140-145. (SCI; MARINE & FRESHWATER BIOLOGY: Rank Factor = 3/110, 2.7%; IF = 5.553)

19. Hseu YC, Chang GR, Pan JY, Rajendran P, Mathew DC, Li ML, Liao JW, Chen WT, Yang HL. Antrodia camphorata inhibits epithelial-to-mesenchymal transition by targeting multiple pathways in triple-negative breast cancers. Journal of Cellular Physiology 2019; 234: 4125-4139. (SCI; PHYSIOLOGY: Rank Factor = 7/81, 8.6%; IF = 6.384)

20. Hou PH, Chang GR, Chen CP, Lin YL, Chao IS, Shen TT, Mao FC. Long-term administration of olanzapine induces adiposity and increases hepatic fatty acid desaturation protein in female C57BL/6J mice. Iranian Journal of Basic Medical Sciences 2018; 21: 495-501. (SCI; MEDICINE, RESEARCH & EXPERIMENTAL: Rank Factor = 94/140, 67.1%; IF = 2.699)

21. Hou PH, Mao FC, Chang GR, Huang MW, Wang YT, Huang SS. Newly Diagnosed Bipolar Disorder and the Subsequent Risk of Erectile Dysfunction: A Nationwide Cohort Study. Journal of Sexual Medicine 2018; 15: 183-191. (SCI; UROLOGY & NEPHROLOGY: Rank Factor = 25/90, 27.8%; IF = 3.802)

22. Chang GR. Persistent organochlorine pesticides in aquatic environments and fishes in Taiwan and their risk assessment. Environmental Science and Pollution Research 2018; 25: 7699-7708. (SCI; ENVIRONMENTAL SCIENCES: Rank Factor = 91/274, 33.2%; IF = 4.223)

23. Chang GR. Surveys on banned veterinary drugs residues in marine bivalves and gastropods in Taiwan between 2010 and 2015: a mini review. Journal of Aquatic Pollution and Toxicology 2017; 1: 1-5.

24. Teng IH, Lee MW, Lin CF, Chang GR. Fibrosarcoma of the lower eyelid in a dog. Integrative Journal of Veterinary Biosciences 2017; 1: 1-3.

25. Chang GR, Chen WK, Hou PH, Mao FC. Isoproterenol exacerbates hyperglycemia and modulates chromium distribution in mice fed with high fat diet. Journal of Trace Elements in Medicine and Biology 2017; 44: 315-321. (SCI; BIOCHEMISTRY & MOLECULAR BIOLOGY: Rank Factor =151/298, 50.7%; IF = 3.849)

26. 張耿瑞、曾昭銘、陳慧珊。以高效能液相層析串聯式質譜儀進行魚及蝦類中13種動物用藥之殘留量調查。台灣農業化學與食品科學期刊。2016; 54(5): 200-211.

27. Chang GR, Chen HS, Chuang WC. Preliminary determination of phthalates in field vegetables and fruits in Taiwan. Taiwanese Journal of Agricultural Chemistry and Food Science 2016; 54: 212-217.

28. Chang GR, Chen HS, Lin FY. Analysis of banned veterinary drugs and herbicide residues in shellfish by liquid chromatography-tandem mass spectrometry (LC/MS/MS) and gas chromatography-tandem mass spectrometry (GC/MS/MS). Marine Pollution Bulletin 2016; 113: 579-584. (SCI; MARINE & FRESHWATER BIOLOGY: Rank Factor = 3/110, 2.7%; IF = 5.553)

29. Chiu TY, Chang GR, Chen WY, Chao TH, Mao FC. The anti-cancer effects of resveratrol combined with 5-fluorouracil treatment in BALB/c mice bearing CT-26 cells. The Journal of Society of Colon and Rectal Surgeon 2016; 27: 65-73.

30. Chang GR, Chen PL, Hou PH, Mao FC. Resveratrol protects against diet-induced atherosclerosis by reducing low-density lipoprotein cholesterol and inhibiting inflammation in apolipoprotein E-deficient mice. Iranian Journal of Basic Medical Sciences 2015; 18(11): 1063-1071. (SCI; MEDICINE, RESEARCH & EXPERIMENTAL: Rank Factor = 94/140, 67.1%; IF = 2.699)

31. Chang GR, Chiu YS, Wu YY, Lin YC, Hou PH, Mao FC. Rapamycin impairs HPD-induced beneficial effects on glucose homeostasis. British Journal of Pharmacology 2015; 172: 3793-3804. (SCI; PHARMACOLOGY & PHARMACY: Rank Factor = 11/275, 4.0%; IF = 8.739)

32. Chao TH, Chang GR, Chen WY, Chen PL, Mao FC. The synergistic effect of rapamycin combined with 5-fluorouracil in BALB/cByJNarl mice bearing CT-26 tumor cells. Anticancer Research 2014;34:3329-3335. (SCI; ONCOLOGY: Rank Factor = 203/244; IF = 1.994)

33. Chan FT, Chang GR, Wang HC, Hsu TH. Anesthesia with isoflurane and sevoflurane in the crested serpent eagle (Spilornis cheela hoya): minimum anesthetic concentration, physiological effects, hematocrit, plasma chemistry and behavioral effects. Journal of Veterinary Medical Science 2013; 75(12): 1591-1600. (SCI; VETERINARY SCIENCES: Rank Factor = 88/146, 60.3%; IF = 1.267)

34. Chan FT, Lin PI, Chang GR, Wang HC, Hsu TH. Hematocrit and plasma chemistry values in adult collared scops owls (Otus lettia) and crested serpent eagles (Spilornis cheela hoya). Journal of Veterinary Medical Science 2012; 74(7): 893-898. (SCI; VETERINARY SCIENCES: Rank Factor = 88/146, 60.3%; IF = 1.267)

35. Chang GR, Yang CC, Hsu SH, Lin C, Chiu CL, Chan FT, Mao FC. Fecal reproductive steroids profiles for monitoring reproductive pattern in female Formosan black bears (Ursus thibetanus formosanus). Annales Zoologici Fennici 2011; 48(5): 275-286. (SCI; ZOOLOGY: Rank Factor = 100/175, 57.1%; IF = 1.324)

36. Chang GR, Wu YY, Chiu YS, Chen WY, Liao JW, Hsu HM, Chao TH, Hung SW, Mao FC. Long-term administration of rapamycin prevents against adiposity, but impairs glucose tolerance in high fat diet-fed KK/HlJ mice. Basic & Clinical Pharmacology & Toxicology 2009; 105(3): 188-198. (SCI; PHARMACOLOGY & PHARMACY: Rank Factor = 102/275, 37.1%; IF = 4.080)

37. Chang GR, Chiu YS, Wu YY, Chen WY, Liao JW, Chao TH, Mao FC. Rapamycin protects against high fat diet-induced obesity in C57BL/6J mice. Journal of Pharmacological Sciences 2009; 109(4): 496-503. (SCI; PHARMACOLOGY & PHARMACY: Rank Factor = 145/275, 52.7%; IF = 3.337) *cited by Selman et al., in Science, vol 326, p.140-144, 2009.

38. Chang GR, Hsu SH, Hsu TH, Yang CC, Chan FT, Mao FC. Seasonal influence on fecal testosterone concentrations of male Formosan black bears (Ursus thibetanus formosanus). European Journal of Wildlife Research. 2009; 55(3): 203-208. (SCI; ZOOLOGY: Rank Factor = 58/175, ; IF = 1.381)

39. Chang GR, Mao FC, Yang CC, Chan FT. Hematological profiles of Formosan black bear (Ursus thibetanus formosanus). Zoolgical Studies 2006; 45(1): 93-97. (SCI; ZOOLOGY: Rank Factor = 78/168, 46.4%; IF = 1.983)

40. 楊吉宗、毛嘉洪、張耿瑞、何東輯、詹芳澤。利用糞類固醇激素監測圈養台灣黑熊的繁殖狀態。特有生物研究。2006; 8(1): 1-11。

41. Chang GR, Mao FC, Yang CC, Chan FT. Seasonal changes in reproductive hormones of female Formosan black bears (Ursus thibetanus formosanus) in captivity. Endemic Species Research 2004; 6(2): 27-34.

(B)研討會論文　

1. 張耿瑞、陳慧珊、林鳳宜。利用液相及氣相層析串聯式質譜儀檢測貝類水產物中禁用之動物用藥及農藥殘留。2015。104年度食品衛生檢驗科技研討會。P.139。(台北) *壁報論文競賽優勝獎

2. Chang GR, Chen HS, Lin CH, Li HP. Determination of chloramphenicols, tetracyclines, and dyes residues by liquid chromatography tandem mass spectrometry in shellfishs. 2012. The Taiwan Association of Veterinary Medicine and Animal Husbandry Spring Symposium. P.95. (台北)

3. Chang GR, Chen HS, Lin CH, Tu CY, Li HP. A survey of veterinary drugs and pesticides residues in aquatic products by liquid/gas chromatography tandem mass spectrometry. 2011. The Taiwan Association of Veterinary Medicine and Animal Husbandry Annual symposium. P.73. (嘉義)

4. Chang GR, Lin CH, Chen HS, Chuang WC, Li HP. Determination of phthalates in vegetables and fruits by LC-MS/MS and GC-MS/MS. 2011. The Taiwan Association of Official Analytical Chemists (AOAC). Annual symposium. P.173. (台北)

5. 張耿瑞。消風散治療犬慢性濕診病例報告。2011。第四屆國際藥王孫思邈醫學論壇研討會。P.707. (台北)

6. Chang GR, Chen HS, Lin CH, Tu CY, Li HP. Simultaneous determination of animals drugs in aquatic products by liquid chromatography tandem mass spectrometry. 2011. Taiwan Society for Mass Spectrometry. P.174. (台北)

7. 林秋華、林利鑫、張耿瑞、李宏萍。利用液相層析飛行時間質譜儀於農產品中多重農藥殘留篩檢技術之應用。2012。第四屆世界華人質譜研討會暨台灣質譜年會。P.161。(台南)

8. Chang GR, Tu CY, Lin FY, Li HP. Determination of formaldehyde in tilapia using 2,4-dinitrophenylhydrazine (DNPH) derivatization by HPLC-UV. 2011. The Taiwan Association of Veterinary Medicine and Animal Husbandry Spring Symposium. P.59. (屏東)

9. 林彥伶、陳京嬪、趙逸璇、沈婷婷、侯伯勳、張耿瑞、毛嘉洪。飲食中補充白胺酸對於奧氮平誘發C57BL/6JNarl小鼠肥胖代謝上之影響。2011。100年度獸醫學相關學會春季聯合學術研討會。P.97。(屏東)

10. 侯伯勳、趙逸璇、陳京嬪、張耿瑞、毛嘉洪。Olanzapine對小鼠體重、體脂肪和肝臟之影響。2010。中華民國獸醫學會暨台灣省畜牧獸醫學會99年度聯合年會暨學術論文發表會。P.37。(台中)

11. Chang GR, Wu YY, Chiu YS, Chen WY, Liao JW, Chiu CL, Hsu HM, Chao TS, Hou PH, Mao FC. mTOR inhibition by rapamycin exacerbates the blood glucose homeostasis but prevents against obesity state in KK/HlJ mice fed a high fat diet. 2010. Asian Federation of Laboratory Animal Science Associations. 4th Congress Meeting. P.111. (台北).

12. Chang GR, Wu YY, Chiu YS, Chen WY, Liao JW, Chiu CL, Hsu HM, Chao TS, Mao FC. Long-term administration of rapamycin improves adiposity in high fat diet-induced obesity KK/HlJ mice. 2009. The Taiwan Association of Veterinary Medicine and Animal Husbandry. Annual Meeting. P.46. (台北).

13. Chiu CL, Chang GR, Mao FC. Acetaminophen aggravated movement of hepatic chromium and hypoglycemia in KK/HlJ mice on high-fat diet. 2008. The Chinese Taipei Society of Laboratory Animal Sciences. Annual Meeting. P.100. (台北).

14. Hsu HM, Chen WY, Chang GR, Mao FC. Extracts of Vitis thunbergii roots protect against the high fat diet-induced obesity in C57BL6/JNarl mice. 2008. The Chinese Taipei Society of Laboratory Animal Sciences. Annual Meeting. P.102. (台北)

15. Chang GR, Wu YY, Chiu YS, Mao FC. Prevention of high fat diet-induced obesity in C57BL6/JNarl mice by the administration of an immunosuppressive drug rapamycin. 2008. The Chinese Taipei Society of Laboratory Animal Sciences. Annual Meeting. P.103. (台北)*壁報論文競賽優勝獎

16. Chang GR, Yang CC, Mao FC. Annual changes in fecal testosterone concentrations of male Formosan black bears (Ursus thibetanus formosanus). 2006. 17th International Conference on Bear Research and Management. P.106. (日本長野)

17. Chang GR, Wu YY, Chiu YS, Mao FC. Rapamycin enhances glucagons-stimulated blood glucose concentration in high fat diet-induced obese mice. 2006.The Taiwan Association of Veterinary Medicine and Animal Husbandry.Spring Symposium. P.59. (嘉義).

18. Chang GR, Yang CC, Chen FT, Mao FC. Hematological profiles of Formosan black bear (Ursus thibetanus formosanus). 2005. The Taiwan Association of Veterinary Medicine and Animal Husbandry.Annual Meeting. P.80. (台中).

(C)其他著作　

1. 吳昆泰、賴政宏、張耿瑞。獸醫針灸與按摩療法-臨床獸醫師中醫基礎暨臨床防治教材。2010。中華亞太小動物中醫學會出版。