姓名

李瑜章 博士  Dr. YU-Jang Li

單位與職稱

應用化學系 教授  Department of Applied Chemistry / Professor

現職

理工學院 副院長  College of Science and Engineering / Deputy Dean

聯絡方式（ Tel or e-mail)：

理工學院 副院長辦公室：理工大樓A16-308室  電話：05-271-7702

05-2717745

E-Mail：yjli@mail.ncyu.edu.tw

學歷： 1995 美國羅徹斯特化學博士 U. of Rochester (Advisor: Prof. Richard H. Schlessinger) 1987 清華大學化學研究所    1985 清華大學化學系

經歷： 1995/5-1996/6 Rensselaer Polytechnic Institute 博士後研究員 (Adviser: Prof. Arthur G. Schultz) 1996/8-2003/7 朝陽科技大學應用化學系副教授 2003/8-2011/7 嘉義大學應用化學系暨研究所副教授 2011/8- 嘉義大學應用化學系暨研究所教授 2013/2-2018/1 嘉義大學國際事務長 2019/8- 嘉義大學應用化學系系主任

專業領域/ Specialized Area： 有機合成 , 不對稱反應 , 具生物活性小分子合成

研究方向/ Research Interests：不對稱反應實驗室介紹 　My research interest has been focused on the studies of ; 1.chiral [2,3]-Wittig rearrangement of g -allyloxy substituted vinylogous urethane enolates 2. [3,3]-Claisen rearrangement of g-allyloxy substituted vinylogous urethanes. 3. Total synthesis of Dendrobatidae Alkaloids (Indolizidine 167B, 209B,209D, 209I, 195G, 223A, 3-epi-223AB, 223AB & 205B)

4. Synthesis of highly-substituted oxetanes 5. [1,2]-Wittig rearrangement of gama-benzyloxy vinylogous urethanes and their synthetic applications.   2014/09/162015/07/21 2015/12/222016/02/262019/05/15 期刊著作/ Publications (2015-)：校務系統研究成果  Total synthesis of Indolizidine Alkaloids (-)-167B, (-)-209I, and (-)-223A by Using a Common Tricyclic Lactone. Yu-Jang Li,* Chung-Chien Hou, and Kuei-Chen Chang. Eur. J. Org. Chem. 2015, 1659-1663. Supported by MOST-103-2113-M-415-009-. IF = 3.065. (19/59, Chemistry, Organic)   Stereoselective Synthesis of 2,3,4-highly Substituted Oxetanes by Intramolecular C-C Bond Forming Michael Addition, Guo-Ming Ho and Yu-Jang Li*. Chem. Commun, 2016, 52, 12108-12111. DOI: 10.1039/C6CC06857J. Supported by NSC 101-2113-M-415-002, MY2. IF =6.319. (14/157, Chemistry, Multidisciplinary). Reviewed by V. Snieckus, B. P. Schuff on SYNFACTS, 2016, 12, 1242. " Stereoselective Preparation of Substituted Oxetanes" Discovery of New Stilbene Antioxidants of the Bio-Elicited Peanut Sprout Powder (BPSP) and Longevity Extension of Mice Fed with BPSP-Supplemented Diets. Robin Y.-Y. Chiou*, Po-Chang Chiu, Ju-Chun Chang, Yu-Jang Li, Chia-Wen Hsieh, Jin-Yi Wu, Shu-Mei Lin, Yun-Lian Lin, Brian B. C. Weng. Food and Nutrition Science, 2017, 8, 141-162.                                                                                                     anti-Selective aldol reactions of chiral alcohol-substituted gama-benzyloxyl vinylogous urethanes and the synthesis of 3-benzyloxyl-4-hydroxylalkane-2-ones. Yu-Jang Li*, Chuan-Chung Chung, Pin-Zu Chen. Tetrahedron: Asymmetry 2017, 28, 1573-1581. https://doi.org/10.1016/j.tetasy.2017.10.003.  Supported by MOST-89-2113-M-324-003, MOST-105-2113-M-415-005. IF=2.379. (22/59, Chemistry, Organic)   Tandem [1,2]-Wittig Rearrangement/Lactonization of gama-benzyloxy vinylogous urethanes: Application to the Synthetic studies of Maculalactone A, Planchol C and gama-Lycorane. Guo-Ming Ho, Yu-Jang Li*. Asian J. Org. Chem. 2018,  7, 145-149. http://dx.doi.org.10.1002/ajoc.201700589. Supported by NSC-100-2119-M-415-001. IF=2.788. (20/59, Chemistry, Organic) Peroxidase characterization isolated from germinated peanut embryos (GPE) and application of the freezed-dried GPE powder as emzyme source for biomimetic production of delta-viniferin. Po-Chang Chiu, Yu-Jang Li, Robin Y.-Y. Chiou*. J. Procbio. 2018, 66, 97-105. DOI: 10.1016/j.procbio.2017.11.019.   C-H Functionalization of Amino Alcohols by Osmium Tetroxide/NMO oor TPAP/NMO: Protection Group-Free Synthesis of Indolizidines (-)-223AB and 3-epi-(-)-223AB. Wei-Lun Chen, Lee-Ya Wang, Yu-Jang Li*. Eur. J. Org. Chem. 2020, 103-107. http://dx.doi.org/10.1002/ejoc.201901494 .                 Undergraduate research students were indicated in blue color.

研討會論文 / Conferences (2015-) 25th Congress of International Society of Heterocyclic Chemistry, ISHC. Short talk 0090, page 75, " Asymmetric Synthesis of Poison Dart Frog Indolizidine Alkaloids".  Yu-Jang Li, Aug 23-28, 2015, UC Santa barbara, USA. The 10th International Conference on Cutting Edge Organic Chemistry in Asia, ICCEOCA-10. PO-C2, page 89. " Tatal Synthesis of Poison Frog Alkaloids". Yu-Jang Li, Chung-Chien Hou, Kuei-Chen Chang and Rou-Jie Huang. Nov. 2-5, 2015. Kaohsiung, Taiwan. 2015 展望 秋季演講系列, 台灣無比精彩(二)-傑出科技成就大觀, "我會忘了我自己嗎? -由熱帶雨林箭毒蛙到阿茲海默藥物開發", 李瑜章. 2015, 11月27日. 台灣大學物理系暨天文物理研究所/國立自然科學博物館. 知識大講堂 中國化學會 104年會研討會論文摘要 OR-099, " Total Synthesis of Dart Frog Indolizidine 167B, 209I and 223A" , Yu-Jang Li, Chung-Chien Hou, Kuei-Chen Chang, 2015年12月5~6日. National Dong Hua University, Hua-Liang. 中國化學會 104年會研討會論文摘要 OR-098, " Total Synthesis of Dart Frog Indolizidine 209B and 209D" , Yu-Jang Li, Lee-Ya Wang, Kui-Chen Chang and Rou-Jie Huang,  2015年12月5~6日. National Dong Hua University, Hua-Liang. 中國化學會 104年會研討會論文摘要 OR-0104, " Total Synthesis of Dart Frog Indolizidine 195G" , Yu-Jang Li, Rou-Jie Huang, 2015年12月5~6日. National Dong Hua University, Hua-Liang. 中國化學會 104年會研討會論文摘要 OR-097, " Total Synthesis of Dart Frog Indolizidine 223V" , Yu-Jang Li, Cheng-Chiao Li, 2015年12月5~6日. National Dong Hua University, Hua-Liang. The 12th International Symposium on Organic Reactions (ISOR-2016), SIL-16B, " Total Synthesis Poison Frog Indolizidine Alkaloids." , Yu-Jang LI, Chung-Chien Hou, Kuei-Chen Chang, Rou-Jie Huang, Lee-Ya Wang, Cheng-Chiao Li, April 22-24, 2016, Kyoto. Japan. ACP-2016-Korea, The 11th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-11). PO-D-13," Applications of Rearrangements of gamma-Allyloxy and gamma-Benzyloxy Vinylogous Urethanes Toward Natural Product Synthesis", Yu-Jang LI, Chung-Chien Hou, Kuei-Chen Chang, Rou-Jie Huang, Lee-Ya Wang, Cheng-Chiao Li, Guo-Ming Ho, Oct 27-30, 2016, KAIST (Daejeon), Korea. International Symposium on Catalysis and Fine Chemicals 2016, C & FC 2016, IL-32. "reactions and Applications Toward Natural Product Synthesis of gamma-Allyloxy and gamma-Benzyloxy Vinylogous Urethanes " Nov 10-14, 2016,  Taipei. 中國化學會 105年會研討會論文摘要 O-075, " Studies on the Synthesis of Penibruguieramine A" , Yu-Jang Li,Wei-Lun Chen, 2016年12月3~4日. National Chung Hsing University, Taichung. 26th Congress of International Society of Heterocyclic Chemistry, ISHC, poster II-13, " Synthetic Application of g-Benzyloxyl Vinylogous Urethanes".  Yu-Jang Li, Sep 3-8, 2017, University of Regensburg, Germany. The 12th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-12), poster B4, " Applications of g-Benzyloxy Vinylogous Urethanes Toward Natural Products and Oxetane Derivative Synthesis". Guo-Ming Ho, Chung-Chien Hou, Cheng-Chiao Li, Yu-Jang Li. Nov. 2-5, 2017. Xi'an China. 中國化學會106年會研討會論文摘要OR-033, "1,3-Oxazolidine and 1,3-oxazines synthesis from oxidative coupling of pyrrolidine with hydroxyl-tethered."Yu-Jang Li, Lee-Ya Wang, Wei-Lun Chen Yen-Shen Liu. 2017年12月1-2日. National Chiayi University, Chiayi. The 13th International Symposium on Organic Reactions (ISOR-13), SIL-6A, "Oxidative Cyclization of Cyclic Tertiary Amines with Tethered Hydroxy Group Mediated by Osmium Tetroxide." Lee-Ya Wang, Wei-Lun Chen, Yu-Jang Li, Nov. 21-24, 2018. Hsinchu, NCTU. 中國化學會107年會研討會論文摘要OR-0132, " Protection Free Synthesis of Indolizidine 223AB Analog.", Wei-Lun Chen, Lee-Ya Wang, Yu-Jang Li. 2018年12月8-9日, NSYSU, Kaohsiung. The 20th Tetrahedron Symposium, P1-87, "Oxidative cyclization of cyclic tertiary amines with tethered hydroxy group mediated by osmium tetroxide and the protection free synthesis of indolizidine 223AB." June 18-21, 2019. Bangkok, Thailand. 中國化學會107年會研討會論文摘要 OR-072. "Catalytic Oxidative Cyclization of Cyclic Aminoalcohols by Osmium tetroxide/NMO or TPAP/NMO and the Protecting Group-Free Synthesis of Indolizidine 223AB and 3-epi-223 AB". Wei-Lun Chen, Lee-Ya Wang, Yu-Jang Li, 2019, Dec 8-12, Taipei, NTU.

研究計畫/ Research Grants： 年 度 計 畫 名 稱 補助機關 89 G-HETERO 取代之 VINYLOGOUS URETHANE ENOLATES 於 CHIRAL ANTI-SELECTIVE ALDOL 反應之研究與合成應用 (89-2113-M-324-012- ) 國科會 90 掌性醇取代之 Vinylogous Urethane 於 syn-selective aldol 反應之研究及其合成應用 (90-2113-M-324-004- ) 國科會 91 間乙烯胺基甲酸酯之烯醇陰離子與醛亞胺的反應研究 (91-2113-M-324-006- ) 國科會 92 珈瑪丙烯氧取代間乙烯胺基甲酸酯烯醇負離子之不對稱 [2, 3]-Wittig 重排反應研究 (92-2113-M-415-005- ) 國科會 93 珈瑪丙烯氧取代間乙烯胺基甲酸酯烯醇負離子之 [2,3]-Wittig 重排反應研究 (2): 二級丙烯氧基取代之研究 (93-2113-M-415-003- )  國科會 94 珈瑪丙烯氧取代間乙烯胺基甲酸酯之熱力 [3,3] 重排反應研究及其合成應用 (94-2113-M-415-003-) 國科會 95 利用珈瑪丙烯氧取代之間乙烯胺酯之[3,3]重排生成之三環化合物進行不對稱反應研究(95-2113-M-415-003-) 國科會 96 利用連結扣甫消去反應與1,3-雙偶極加成反應以合成咯里西啶及哆里西啶類化合物之反應及合成研究(96-2113-M-415-002-) 國科會 97 貝他胺取代酯類化合物之連結扣甫消去反應與1,3-雙偶極環化加成反應之反應與合成應用研究 (97-2113-M-415-002) 國科會 98 重點二子題1：利用掌性三環化合物開發新合成方法以合成比咯哩西啶及引朶哩西啶架構之研究. (98-2119-M-415-001) 國科會  99  重點二子題1: 利用掌性三環化合物進行分子內自由基環化反應之研究及其於比咯哩西啶及引朵哩西啶架構之合成應用 (99-2119-M-415-001-) 國科會 100 重點二子題1: 珈瑪苯甲氧基間烯胺酯之不對稱 [1,2]- 重排反應及其合成應用研究 (100-2119-M-415-001-) 國科會 101 利用間烯胺酯化合物以合成含氧雜環化合物衍生物之研究 (101-2113-M-415-002-MY2)-1/2 國科會 102 利用間烯胺酯化合物以合成含氧雜環化合物衍生物之研究 (101-2113-M-415-002-MY2)-2/2 國科會 103 多取代引朶哩西啶天然物之總合成研究 (103-2113-M-415-009-) 科技部 104 105 106 107 109 多取代引朶哩西啶天然物之總合成研究(2) (104-2113-M-415-001) 生物鹼盤尼布蓋爾胺之總合成及其類似物之合成研究 (105-2113-M-415-005) 鄰氮碳之催化氧化研究與天然物總合成應用 (106-2113-M-415-001) 具雙鍵分子鄰氮碳之氧化加成反應研究 (107-2113-M-415-005) 2018/8-2020/7 四氧化鋨在貝它羥基環胺類化合物之合成與機制研究(109-2113-M-415-003) 科技部 科技部 科技部 科技部 科技部

教授課目： 有機化學、有機反應、有機光譜、藥物化學、觸媒化學