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一、學歷
(Advisor: Prof.Charlie
G. Riordan)
二、經歷
2018/2-2022/1 嘉義大學 環安中心 環保組 組長 2011/10- 法務部矯正署嘉義看守所自營作業指導委員 2010/8- 嘉義大學 副教授 2005/8-2010/7 嘉義大學 助理教授 2004/8-2005/7 清華大學化學系 博士後研究 1996/8-1998/7 彰化師範大學 研究助理
三、專業領域 Bioinorganic/organicmetallic Chemistry (生物無機/有機金屬化學 ) Metal biomedical materials (金屬生物醫學材料) NO Release Agent for Repellent / Attraction of Mosquito (一氧化氮蚊蟲忌避/誘引材料之開發) Development of cosmetic materials (妝品材料之開發)
四、連絡方式 Location: 應化一館 A17-303 Tel: 05-271-7951 Email: genechiou@mail.ncyu.edu.tw
五、研究方向 1. 本實驗室之研究精神啟發於自然，研究基礎則為鐵基一氧化氮釋放分子(Iron-based nitric oxide release molecule, Fe-NORM 例如Roussin’s Red Esters, RREs)之合成，從小分子Fe-NORM至聚合奈米微胞，其性質、結構、一氧化氮釋放之條件、量之調整，乃至於Fe-NORM中引入各式螢光基團追蹤藥物進入生物體之路徑與反應機制，均是實驗室之研究重點，最後更可回饋自然，用其研究埃及斑蚊之生長抑制，亦可作為使腫瘤周邊血管正常化之潛力抗癌偕同藥物，芘基系列分子(Pyrene-Fe-NORM)亦已確認可運用於發光材料與能源產氫之催化劑。
2. 具體產業應用：
埃及斑蚊防治、醫藥-抗癌偕同藥物、發光材料、zero gap AEM電解水綠氫模組
六、研究計畫列表
七、期刊論文: 校務系統研
1. Show-Jen Chiou, Yi-Chien Lin, Yi-Fu Chang, Yu-Fen Chen, Tzu-Hao Lo, Chia-Shen Tsai, Hung-Chun Liao, Pei-Yi Tsai, Shih-Hsien Chuang, and Jiann-Jyh Huang*Copper I Catalyzed Intramolecular Tandem Acylation O-Arylation under Mild Conditions Synthesis of Benzofuro 3,2- cquinolin-6(5 H)-ones and G-Quadruplex-Targeting Analogues JOC, 2024, 90, 794-805.
2. Chieh-Wei Chung, Bo-Wen Liao, Shu-Wei Huang, Show-JenChiou, Cheng HanChang, Sheng-JuLin, Bo-Hao Chen, Wei-Ling Liu, Shang-Hsiu Hu, Yu-Chun Chuang, Chia-Her Lin, I-Jui Hsu, Chao-Min Cheng, Chieh-Cheng Huang, and Tsai-Te Lu* Magnetic Responsive Release of Nitric Oxide from an MOF-Derived Fe3O4 @PLGA Microsphere for the Treatment of Bacteria-Infected Cutaneous Wound ACS Applied Materials and Interfaces 2022, 14(5), 6343-6357. 3. Yun-Chieh Sung1,2, Pei-Ru Jin1, Li-An Chu3, Fu-Fei Hsu4, Mei-Ren Wang5, Chih-Chun Chang1, Show-Jen Chiou6, Jiantai Timothy Qiu7,8,9, Dong-Yu Gao1, Chu-Chi Lin9, Yu-Sing Chen9, Yi-Chiung Hsu10, Jane Wang2, Fu-Nien Wang11, Pei-Lun Yu11, Ann-Shyn Chiang 3,12,13,14, Anthony Yan-Tang Wu15,16,17, John Jun-Sheng Ko1,15, Charles Pin-Kuang Lai 15,16,18, Tsai-Te Lu 1,5* Yunching Chen 1*, Delivery of nitric oxide with a nanocarrierpromotes tumour vessel normalization and potentiates anti-cancer therapies. Nature Nanotechnology, 2019, 12, 1160-1169. 4. Tsai-Te Lu*,†, Yun-Ming Wang*,‡, Chen-Hsiung Hung*,§, Show-Jen Chiou*, Wen-Feng Liaw*, Bioinorganic Chemistry of the Natural Fe(NO)2 Motif: Evolution of a Functional Model for NO-Related Biomedical Application and Revolutionary Development of a Translational Model. Inorg Chem, 2018, 57, 12425-12443. 5. Tsai-Te Lu, Hsiao-Wen Huang, Chia-Her Lin, Yu-Ting Tseng, Wen-Feng Liaw, Hsi-Ya Huang, Show-Jen Chiou “DINITROSYL IRON COMPLEX, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, COMPOSITE MATERIAL COMPRISING THE SAME, AND USES THEREOF” U.S. Patent Application No. 15/413,428, January 24, 2017. 6. Show-Jen Chiou; Yu-Der Wen, " Effects of curcumin on nitrosyl-iron complex-mediated DNA cleavage and cytotoxicity. Rong-Jen Shiau, Jheng-Yu Wu,," Planta Med, 2012, 78, 1342-1350. 7. Show-Jen Chiou 1, Arnold L. Rheingold 2, Glenn P.A. Yap, Charles G. Riordan, Coordination chemistry of pyrazolylbis((alkylthio)methyl)borates: Hybrid nitrogen and sulfur donor ligands, Inorganica Chimica Acta., 2010, 364, 81-88. 8. Chien-Hong Chen*, Show-Jen Chiou,*,and Hsuan-Yin Chen, Dinuclear [{Fe(NO)2}10-{Fe(NO)2}10] Dinitrosyl Iron Complex with Thiolate-CO-Bridged Ligands, Inorg. Chem., 2010, 49, 2023-2025. 9. Yu-Der Wen, Yun-Lung Ho, Rong-Jen Shiau, Jung-Kai Yeh, Jheng-Yu Wu, Wei-Lung Wang, Show-Jen Chiou*, Synergistic antitumor effect of curcumin and dinitrosyl iron complexes for against melanoma cells, J. Organomet Chem., 2010, 695, 352. 10. H.-H. Chang; H.-J. Huang; Y.-L. Ho; Y.-D. Wen; W.-N. Huang; S.-J. Chiou*.The water-soluble Roussin’s red ester acting as a potential photochemical NO-delivery agent: Photolysis reactions, DNA cleavage and anticancer activity. Dalton Trans, 2009, 6396. 11. S.-J Chiou*; C.-C. Wang, C.-M. Chang, Synthesis of dinitrosyl iron complexes (DNICs) with intramolecular hydrogen bonding. JOMC, 2008, 693, 3582.
八、研討會論文
2024 Carbon Footprint Assessment of NCYU-TN1, A New Drought Tolerant Rice Cultivar from NCYU. Third Trilateral Symposium on Sustainability 2023 The Applications of Fluorescent Iron-based Nitric Oxide Release Molecules. The International Conference of Biological Inorganic Chemistry. Adelaide. Australian 2023 Photo-Activated, Cell-Penetrating, Fluorescent Iron-based Nitric Oxide Release Molecules (NORMs): Synthesis, Characterization, and Potential Applications TBIC 2023 Synthesis and Application of Roussin’s Red Ester with Pyrene Derivatives with α-Ketoamide Structure as Peroxyl Radical Probes TBIC 2022 The Growth Regulation of Aedes aegypti Larvae by the Iron-based Nitric Oxide Release Molecules TBIC 2022 Synthesis ana characterization of Roussin Red Esters with Derivatives of Pyene Group for the detection of ROS The 8th Asian Conference on Coordination Chemistry (ACCC) 2022 The Applications of Fluorescent Iron-based Nitric Oxide Release Molecules 20th International Conference of Biological Inorganic Chemistry
九、研究/委辦計畫 1. 2021/01/01-2021/01/15咖啡葉萃取液面膜研發委辦計畫(農委會) 2. 2020/01/01-2020/12/31咖啡葉萃取液保養品研發計畫(農委會) 3. 2017/06/01-2018/10/31產學合作計畫-新穎蚊子忌避與誘引劑材料之開發、測試與應用。(科技部) 4. 2015/09/01-2016/05/31創新環保綠色商機:複合型天然美白化妝品開發整合服務計畫。(SBIR) 5. 2014/08/01-2015/07/31水相光敏含螢光基團具一氧化氮釋放能力之金屬錯合物:合成,特質, DNA斷切及抗癌能力之探討。(科技部) 6. 2014/06/20-2014/10/20化妝保養品中天然抗UV原料的創新與開發。(經濟部) 7. 2011/08/01-2014/07/31 水溶性、光敏含鐵一氧化氮化合物之設計合成、性質、 DNA切割及抗癌活性之探討。(國科會) 8. 2010/08/1-2011/7/31 由結合氨基酸及胜 之水溶性 2-雙羥甲基磷 -1-硫醇乙烷所修飾之亞硝化鐵錯合物 :合成、特性、 DNA斷切及抗腫瘤效應之探討。( 國科會） 9. 2009/08/01-2010/07/31 潛力之光化學一氧化氮藥物前驅物之合成、光反應、DNA切割及蛋白質活化。( 國科會） 10. 2008/08/01-2009/07/31生化擬態之DNIC及RRE性質探討:結構及一氧化氮釋放對DNA切割及蛋白質。( 國科會） 10. 2007/08/01-2008/07/31生化擬態之DNIC及RRE性質探討:結構及一氧化氮釋放對DNA切割及蛋白質活化的影響。( 國科會）
十、教授課目 無機化學、觸媒化學、高等無機化學、有機金屬化學、生物無機化學、環境化學特論、通識-科學與生活、通識-化學與生活
十一、實驗室成員:
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