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一、學歷
(Advisor: Prof.Charlie
G. Riordan)
二、經歷
2018/2-2022/1 嘉義大學 環安中心 環保組 組長 2011/10- 法務部矯正署嘉義看守所自營作業指導委員 2010/8- 嘉義大學 副教授 2005/8-2010/7 嘉義大學 助理教授 2004/8-2005/7 清華大學化學系 博士後研究 1996/8-1998/7 彰化師範大學 研究助理
三、專業領域 Bioinorganic/organicmetallic Chemistry (生物無機/有機金屬化學 ) Metal biomedical materials (金屬生物醫學材料) NO Release Agent for Repellent / Attraction of Mosquito (一氧化氮蚊蟲忌避/誘引材料之開發) Development of cosmetic materials (妝品材料之開發)
四、連絡方式 Location: 應化一館 A17-303 Tel: 05-271-7951 Email: genechiou@mail.ncyu.edu.tw
五、研究方向 1. 本實驗室之研究精神啟發於自然，研究基礎則為鐵基一氧化氮釋放分子(Iron-based nitric oxide release molecule, Fe-NORM 例如Roussin’s Red Esters, RREs)之合成，從小分子Fe-NORM至聚合奈米微胞，其性質、結構、一氧化氮釋放之條件、量之調整，乃至於Fe-NORM中引入各式螢光基團追蹤藥物進入生物體之路徑與反應機制，均是實驗室之研究重點，最後更可回饋自然，用其研究埃及斑蚊之生長抑制，亦可作為使腫瘤周邊血管正常化之潛力抗癌偕同藥物，芘基系列分子(Pyrene-Fe-NORM)亦已確認可運用於發光材料與能源產氫之催化劑。
2. 具體產業應用：
埃及斑蚊防治、醫藥-抗癌偕同藥物、發光材料、zero gap AEM電解水綠氫模組
六、近五年之學術著作 1. Chieh-Wei Chung, Bo-Wen Liao, Shu-Wei Huang, Show-JenChiou, Cheng HanChang, Sheng-JuLin, Bo-Hao Chen, Wei-Ling Liu, Shang-Hsiu Hu, Yu-Chun Chuang, Chia-Her Lin, I-Jui Hsu, Chao-Min Cheng, Chieh-Cheng Huang, and Tsai-Te Lu* Magnetic Responsive Release of Nitric Oxide from an MOF-Derived Fe3O4 @PLGA Microsphere for the Treatment of Bacteria-Infected Cutaneous Wound ACS Applied Materials and Interfaces 2022, 14(5), 6343-6357. 2. Yun-Chieh Sung1,2, Pei-Ru Jin1, Li-An Chu3, Fu-Fei Hsu4, Mei-Ren Wang5, Chih-Chun Chang1, Show-Jen Chiou6, Jiantai Timothy Qiu7,8,9, Dong-Yu Gao1, Chu-Chi Lin9, Yu-Sing Chen9, Yi-Chiung Hsu10, Jane Wang2, Fu-Nien Wang11, Pei-Lun Yu11, Ann-Shyn Chiang 3,12,13,14, Anthony Yan-Tang Wu15,16,17, John Jun-Sheng Ko1,15, Charles Pin-Kuang Lai 15,16,18, Tsai-Te Lu 1,5* Yunching Chen 1*, Delivery of nitric oxide with a nanocarrierpromotes tumour vessel normalization and potentiates anti-cancer therapies. Nature Nanotechnology, 2019, 12, 1160-1169. 3. Tsai-Te Lu*,†, Yun-Ming Wang*,‡, Chen-Hsiung Hung*,§, Show-Jen Chiou*, Wen-Feng Liaw*, Bioinorganic Chemistry of the Natural Fe(NO)2 Motif: Evolution of a Functional Model for NO-Related Biomedical Application and Revolutionary Development of a Translational Model. Inorg Chem, 2018, 57, 12425-12443.
4. Tsai-Te Lu,
Hsiao-Wen Huang, Chia-Her Lin, Yu-Ting Tseng, Wen-Feng Liaw, Hsi-Ya
Huang, Show-Jen Chiou “DINITROSYL IRON COMPLEX, PHARMACEUTICAL
COMPOSITION COMPRISING THE SAME, COMPOSITE MATERIAL COMPRISING THE SAME, AND
USES THEREOF” U.S. Patent Application No. 15/413,428, January 24, 2017.
七、研究計畫列表
八、期刊論文: 校務系統研 1. Chieh-Wei Chung, Bo-Wen Liao, Shu-Wei Huang, Show-JenChiou, Cheng HanChang, Sheng-JuLin, Bo-Hao Chen, Wei-Ling Liu, Shang-Hsiu Hu, Yu-Chun Chuang, Chia-Her Lin, I-Jui Hsu, Chao-Min Cheng, Chieh-Cheng Huang, and Tsai-Te Lu* Magnetic Responsive Release of Nitric Oxide from an MOF-Derived Fe3O4 @PLGA Microsphere for the Treatment of Bacteria-Infected Cutaneous Wound ACS Applied Materials and Interfaces 2022, 14(5), 6343-6357. 2. Yun-Chieh Sung1,2, Pei-Ru Jin1, Li-An Chu3, Fu-Fei Hsu4, Mei-Ren Wang5, Chih-Chun Chang1, Show-Jen Chiou6, Jiantai Timothy Qiu7,8,9, Dong-Yu Gao1, Chu-Chi Lin9, Yu-Sing Chen9, Yi-Chiung Hsu10, Jane Wang2, Fu-Nien Wang11, Pei-Lun Yu11, Ann-Shyn Chiang 3,12,13,14, Anthony Yan-Tang Wu15,16,17, John Jun-Sheng Ko1,15, Charles Pin-Kuang Lai 15,16,18, Tsai-Te Lu 1,5* Yunching Chen 1*, Delivery of nitric oxide with a nanocarrierpromotes tumour vessel normalization and potentiates anti-cancer therapies. Nature Nanotechnology, 2019, 12, 1160-1169. 3. Tsai-Te Lu*,†, Yun-Ming Wang*,‡, Chen-Hsiung Hung*,§, Show-Jen Chiou*, Wen-Feng Liaw*, Bioinorganic Chemistry of the Natural Fe(NO)2 Motif: Evolution of a Functional Model for NO-Related Biomedical Application and Revolutionary Development of a Translational Model. Inorg Chem, 2018, 57, 12425-12443. 4. Tsai-Te Lu, Hsiao-Wen Huang, Chia-Her Lin, Yu-Ting Tseng, Wen-Feng Liaw, Hsi-Ya Huang, Show-Jen Chiou “DINITROSYL IRON COMPLEX, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, COMPOSITE MATERIAL COMPRISING THE SAME, AND USES THEREOF” U.S. Patent Application No. 15/413,428, January 24, 2017. 5. Show-Jen Chiou; Yu-Der Wen, " Effects of curcumin on nitrosyl-iron complex-mediated DNA cleavage and cytotoxicity. Rong-Jen Shiau, Jheng-Yu Wu,," Planta Med, 2012, 78, 1342-1350. 6. Show-Jen Chiou 1, Arnold L. Rheingold 2, Glenn P.A. Yap, Charles G. Riordan, Coordination chemistry of pyrazolylbis((alkylthio)methyl)borates: Hybrid nitrogen and sulfur donor ligands, Inorganica Chimica Acta., 2010, 364, 81-88. 7. Chien-Hong Chen*, Show-Jen Chiou,*,and Hsuan-Yin Chen, Dinuclear [{Fe(NO)2}10-{Fe(NO)2}10] Dinitrosyl Iron Complex with Thiolate-CO-Bridged Ligands, Inorg. Chem., 2010, 49, 2023-2025. 8. Yu-Der Wen, Yun-Lung Ho, Rong-Jen Shiau, Jung-Kai Yeh, Jheng-Yu Wu, Wei-Lung Wang, Show-Jen Chiou*, Synergistic antitumor effect of curcumin and dinitrosyl iron complexes for against melanoma cells, J. Organomet Chem., 2010, 695, 352. 9. H.-H. Chang; H.-J. Huang; Y.-L. Ho; Y.-D. Wen; W.-N. Huang; S.-J. Chiou*.The water-soluble Roussin’s red ester acting as a potential photochemical NO-delivery agent: Photolysis reactions, DNA cleavage and anticancer activity. Dalton Trans, 2009, 6396.
10. S.-J Chiou*; C.-C. Wang, C.-M. Chang, Synthesis of dinitrosyl iron complexes (DNICs) with intramolecular hydrogen bonding. JOMC, 2008, 693, 3582.
九、研討會論文 1. Development of a novel plant extract for mosquito repellent and attractant. ICOM (19), 2018/11/24-2018/11/26, Taichung Taiwan.
2. Dinitrosyl Iron Complexes with Bischromophoric Pyrene for Water Splitting, CSLT, 2017/12/01-2017/12/02, Chiayi Tauwan.
3. 新穎斑蚊忌避與誘引劑複合植物萃液液之開發, CSLT, 2017/12/01-2017/12/02, Chiayi Taiwan.
4. Roussin’s Red Esters as Luminescent Sensors and Carriers of Nitric Oxide, TBIC, 2016/11/15, Kaohsiung Taiwan.
5. Synthesis of Photochemical NO–Release Molecules (NO-RMs) with Biomolecular Vectors and their Anticancer Activity. ICBIC(16) 2013/7/22-2013/7/26 Grenbole France
6. Synthesis of Potential Photochemical NO–Release Molecules (NO-RM), DNICs & RREs with Specific Biomolecular Vectors. ASBIC(6) 2012/11/5-2012/11/8 Hongkong China
十、研究/委辦計畫 1. 2021/01/01-2021/01/15咖啡葉萃取液面膜研發委辦計畫(農委會) 2. 2020/01/01-2020/12/31咖啡葉萃取液保養品研發計畫(農委會) 3. 2017/06/01-2018/10/31產學合作計畫-新穎蚊子忌避與誘引劑材料之開發、測試與應用。(科技部) 4. 2015/09/01-2016/05/31創新環保綠色商機:複合型天然美白化妝品開發整合服務計畫。(SBIR) 5. 2014/08/01-2015/07/31水相光敏含螢光基團具一氧化氮釋放能力之金屬錯合物:合成,特質, DNA斷切及抗癌能力之探討。(科技部) 6. 2014/06/20-2014/10/20化妝保養品中天然抗UV原料的創新與開發。(經濟部) 7. 2011/08/01-2014/07/31 水溶性、光敏含鐵一氧化氮化合物之設計合成、性質、 DNA切割及抗癌活性之探討。(國科會) 8. 2010/08/1-2011/7/31 由結合氨基酸及胜 之水溶性 2-雙羥甲基磷 -1-硫醇乙烷所修飾之亞硝化鐵錯合物 :合成、特性、 DNA斷切及抗腫瘤效應之探討。( 國科會） 9. 2009/08/01-2010/07/31 潛力之光化學一氧化氮藥物前驅物之合成、光反應、DNA切割及蛋白質活化。( 國科會） 10. 2008/08/01-2009/07/31生化擬態之DNIC及RRE性質探討:結構及一氧化氮釋放對DNA切割及蛋白質。( 國科會） 10. 2007/08/01-2008/07/31生化擬態之DNIC及RRE性質探討:結構及一氧化氮釋放對DNA切割及蛋白質活化的影響。( 國科會）
十一、教授課目 無機化學、觸媒化學、高等無機化學、有機金屬化學、生物無機化學、環境化學特論、通識-科學與生活、通識-化學與生活
十二、實驗室成員:
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