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鄭偉杰
As Genomics Research Center (chemistry and chemical biology division), Academia Sinica, Taiwan sociate Research Fellow, 副研究員
Telephone: (02) 2787-1262.
Email: wcheng@gate.sincia.edu.tw
Education
2002 Ph D. Department of Chemistry, University of California, Davis, CA, USA
1993 M.S. Department of Chemistry, National Tsing-Hua University, Hsinchu, Taiwan
1991 B.S. Chemistry, National Cheng-Kung National University, Taiwan
Professional Experience
2010-present Associate Research Fellow, Genomics Research Center, Academia Sinica, Taipei, Taiwan
2004-2010 Assistant Research Fellow, Genomics Research Center, Academia Sinica, Taipei, Taiwan
2002-2004 Postdoctoral Fellow, The Scripps Research Institute, USA
Honors
2013 Outstanding Young Researcher Grants, Taiwan
2007 The distinguished lectureship award (Natural products synthesis), The CSJ (Chemical society of Japan) Asian International Symposium, Japan, 2007
2002-2004 The Skaggs postdoctoral Fellowship
Research Experience
Dr. Cheng received his B.S. (1991) degree in Chemistry from National Cheng-Kung University, Taiwan and M.S. (1993) degree in Chemistry from National Tsing-Hua University, Taiwan. After military service (two years) and experience as a research assistant, he started his Ph.D. program at UC-Davis, USA in 1997. He received his Ph.D. degree in Chemistry from University of California, Davis, CA, USA (1997-2002). He then worked in Chemistry at the Scripps Research Institute, San Diego, USA as a postdoctoral fellow (2002-2004). Dr. Cheng started his independent career as Assistant Research Fellow at the Genomics Research Center at Academia Sinica, Taipei, Taiwan in 2004 and became Associate Research Fellow in 2010.
Research Interests
The major research efforts of our group are directed toward the development of new synthetic strategies for biologically interesting natural products and heterocycles. To understand the relationships between small molecules and biological systems, combinatorial approaches are applied in our diverse molecule library synthesis (core diversity, substituent diversity, and configuration diversity) with the assistance of automated or semi-automated equipment. Research interests include: Organic chemistry, Synthetic methodology, Natural product and bioactive molecule synthesis, Matrix-supported organic synthesis, Combinatorial chemistry, Synthesis of new glycophospholipids, Synthesis and functional study of Novel iminosugar alkaloids, Natural product-like library synthesis, Synthesis of bacterial (mycobacterial) cell wall components, Development of new chemical probes for biological applications, Pathogen host interaction, New molecules for innate immune study, Bioorganic chemistry, Chemical biology, Small molecules as chemical chaperones or specific stabilizers of protein drugs for potential treatments of lysosomal storage diseases, Development of new antibiotics, and Drug discovery. Recently, our lab is dedicated to “natural product inspired combinatorial chemistry” and its applications.
Publications
1. A combinatorial approach towards the synthesis of non-hydrolysable triazole–iduronic acid hybrid inhibitors of human α-L-iduronidase: discovery of enzyme stabilizers for the potential treatment of MPSI”. Chem. Commun., 2018, 54, 2647 – 2650
2. Wei-Shen Wu, Wei-Chieh Cheng, Ting-Jen R. Cheng, and Chi-Huey Wong, Affinity-Based Screen for Inhibitors of Bacterial Transglycosylase, Journal of the American Chemical Society 2018 140 (8), 2752-2755
3. Huang-Yi Li, Jay-Der Lee, Chiao-Wen Chen, Ying-Chieh Sun, and Wei-Chieh Cheng*, “Synthesis of (3S,4S,5S)-trihydroxylpiperidine derivatives as enzyme stabilizers to improve therapeutic enzyme activity in Fabry patient cell lines”,
Eur J Med Chem. 2018, 144, 626-634.
4. Kuo-Ting Chen, Yi-Fan Chang, Chia-Ming Hu, Cheng-Kun Lin, Ting-Jen R. Cheng and Wei-Chieh Cheng*, “Effect of the Lipid II Sugar Moiety on Bacterial Transglycosylase: the 4-Hydroxy Epimer of Lipid II is a TGase Inhibitor”, Chem. Commun., 2017, 53, 771-774
5. Wei-Chieh Cheng*, Jen-Hon Wang,Wen-Yi Yun,Huang-Yi Li, Jia-Ming Hu,”Rapid preparation of (3R,4S,5R) polyhydroxylated pyrrolidine-based libraries to discover a pharmacological chaperone for treatment of Fabry disease”, Eur J Med Chem. 2017, 126, 1-6.
7. Cheng-Kun Lin, Chung-Chien Hou, Yi-Yong Guo, and Wei-Chieh Cheng.*, “Design and Synthesis of Orthogonally Protected D- and L-β-Hydroxyenduracididines from D-Lyxono-1,4-lactone”, 2016, Org Lett., 18, 5216-5219.
8. Wei-Chieh Cheng*, Wang JH, Li HY, Lu SJ, Hu JM, Yun WY, Chiu CH, Yang WB, Chien YH, Hwu WL,, “Bioevaluation of sixteen ADMDP stereoisomers toward alfa-galactosidase A: Development of a new pharmacological chaperone for the treatment of Fabry disease and potential enhancement of enzyme replacement therapy efficiency”, Eur J Med Chem. 2016, 123, 14-20.
9. A Concise Approach Towards the Synthesis of the Unique N-Mannsoyl D-β-Hydroxyenduracididine Moiety in the Mannopeptimycin Series of Natural Products, Org. Biomol. Chem., 2016, 14, 4054-4060
10. Johannes Zuegg, Craig Muldoon, George Adamson, Declan McKeveney, Giang Le Thanh, Rajaratnam Premraj, Bernd Becker, Mu Cheng, Alysha G. Elliott, Johnny X. Huang, Mark S. Butler, Megha Bajaj, Joachim Seifert, Latika Singh, Nicola F. Galley, David I. Roper, Adrian J. Lloyd, Christopher G. Dowson, Ting-Jen Cheng, Wei-Chieh Cheng, Dieter Demon, Evelyne Meyer, Wim Meutermans, Matthew A. Cooper*, “Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity”, Nat. Commun., 2015, 6, 7719.
11. Cheng-Kun Lin, Li-Wei Cheng, Huang-Yi Li, Wen-Yi Yun, Wei-Chieh Cheng*, “Synthesis of Novel Polyhydroxylated Pyrrolidine–triazole/-isoxazole Hybrid Molecules”, Org. Biomol. Chem. 2015, 13, 2100–2107.
12. Po-Ting Chen, Cheng-Kun Lin, Chih-Ju Tsai, Duen-Yi Huang, Fu-Yao Nien, Wan-Wan Lin, Wei-Chieh Cheng*, “Expeditious Synthesis of Enantiopure, Orthogonally Protected Bis α-Amino Acids (OPBAAs) and their Use in a Study of Nod1 Stimulation”, Chem. Asian J. 2015, 10, 474–482.
13. Wei-Chieh Cheng*, Chih-Wei Guo, Cheng-Kun Lin, Yu-Ruei Jiang, “Synthesis and Inhibition Study of Bicyclic Iminosugar-Based Alkaloids, Scaffolds, and Libraries towards Glucosidase”, Isr. J. Chem. 2015, 55(3-4), 403-411.
14. Cheng-Kun Lin, Kuo-Ting Chen, Chia-Ming Hu, Wen-Yi Yun, Wei-Chieh Cheng*, “Synthesis of 1-C-glycoside Linked Lipid II Analogues toward Bacterial Transglycosylase Inhibition Study”, Chem. Eur. J. 2015, 21, 7511-9.
15. Kuo-Ting Chen, Duen-Yi Huang, Cheng-Hsin Chiu, Wan-Wan Lin, Pi-Hui Liang, Wei-Chieh Cheng*, “Synthesis of Diverse N-Substituted Muramyl Dipeptide Derivatives and Their Use in a Study of Human NOD2 Stimulation Activity. ” Chem. Eur. J. 2015, 21, 11984-11988.
16. Tseng, Yen-Yu; Liou, Jyh-Ming; Hsu, Tsui-Ling; Cheng, Wei-Chieh; Wu, Ming-Shiang*; Wong, Chi-Huey*, “Development of bacterial transglycosylase inhibitors as new antibiotics: moenomycin A treatment for drug-resistant Helicobacter pylori.”, Bioorganic & medicinal chemistry letters, 24(11), 2412-2414. (SCI)
17. Huang, Lin-Ya; Huang, Shih-Hsien; Chang, Ya-Chih; Cheng, Wei-Chieh; Cheng, Ting-Jen R.*; Wong, Chi-Huey*, “Enzymatic Synthesis of Lipid II and Analogues.”, Angewandte Chemie-International Edition, 53(31), 8060-8065. (SCI)
18. Hsu, Che-Hsiung; Schelwies, Mathias; Enck, Sebastian; Huang, Lin-Ya; Huang, Shih-Hsien; Chang, Yi-Fan; Cheng, Ting-Jen Rachel; Cheng, Wei-Chieh; Wong, Chi-Huey*, 2014, “Iminosugar C-Glycoside Analogues of alpha-d-GlcNAc-1-Phosphate: Synthesis and Bacterial Transglycosylase Inhibition. ”, The Journal of Organic Chemistry, 79(18), 8629-8637. (SCI)
19. New continuous fluorometric assay for bacterial transglycosylase using Forster resonance energy transfer., J. Am. Chem. Soc. 2013, 135, 17078-89.
20. Rapid modifications of N-substitution in iminosugars: development of new beta-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease., Bioorg. Med. Chem. 2013, 21, 5021-8.
21. Rapid preparation of mycobacterium N-glycolyl Lipid I and Lipid II derivatives: a biocatalytic approach., Chem. Eur. J. 2013, 19, 834-8.
22. Pan Y.-W.; Guo C.-W.; Tu H.-Y.; Tsai C.-W.; Cheng W.-C.*, Solid-Phase Synthesis of Diverse Spiroisoxazolinodiketopiperazines. ACS Comb. Sci. 2013, 15, 425-34.
23. From Natural Product-Inspired Pyrrolidine Scaffolds to the Development of New Human Golgi alpha-Mannosidase II Inhibitors., Chem. Asian J. 2013, 8, 2600-4.
24. Shih, H.-W.; Chang, Y.-F.; Li, W.-J.; Meng, F.-C.; Huang, C.-Y.; Ma, C.; Cheng, T.-J. R.; Wong, C.-H.; Cheng, W.-C.*, Effect of the Peptide Moiety of Lipid II on Bacterial Transglycosylase, Angew. Chem. Int. Ed. 2012, 51, 10123-26. (IF: 13.4) (corresponding author, (corresponding author, 7/152 in chemistry, multidisciplinary)
25. Huang, C.-Y.; Shih, H.-W.; Lin, L.-Y.; Tien, Y.-W.; Cheng, T.-J. R.; Cheng, W.-C.; Wong, C.-H.; Ma, C.: Crystal structure of Staphylococcus aureus transglycosylase in complex with a lipid II analog and elucidation of peptidoglycan synthesis mechanism. Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 6496-6501.
26. Shih, H.-W.; Chen, K.-T.; Cheng, W.-C.: One-pot synthesis of phosphate diesters and phosphonate monoesters via a combination of microwave-CCl3CN-pyridine coupling conditions. Tetrahedron Lett. 2012, 53, 243-246. (corresponding author)
27. Hsu, Y.-C.; Chen, N.-C.; Chen, P.-C.; Wang, C.-C.; Cheng, W.-C.; Wu, H.-N.: Identification of a small-molecule inhibitor of dengue virus using a replicon system. Arch. Virol. 2012, 157, 681-688.
28. Meng, F.-C.; Chen, K.-T.; Huang, L.-Y.; Shih, H.-W.; Chang, H.-H.; Nien, F.-Y.; Liang, P.-H.; Cheng, T.-J. R.; Wong, C.-H.; Cheng, W.-C.: Total Synthesis of Polyprenyl N-Glycolyl Lipid II as a Mycobacterial Transglycosylase Substrate. Org. Lett. 2011, 13, 5306-5309. (IF: 5.25) (corresponding author, 4/55 in chemistry, organic)
29. Shih, H.-W.; Chen, K.-T.; Cheng, T.-J. R. Wong, C.-H.; Cheng, W.-C. A new synthetic approach toward bacterial transglycosylase substrates, Lipid II and Lipid IV. Org. Lett. 2011, 13 (17), 4600-4603. (IF: 5.25) (corresponding author, 4/55 in chemistry, organic)
30. Chang, Y.-F.; Guo, C.-W.; Chan, T.-H.; Pan, Y.-W.; Tsou, E.-L.; Cheng, W.-C., Parallel synthesis of natural product-like polyhydroxylated pyrrolidine and piperidine alkaloids. Mol. Diversity 2011, 15 (1), 203-214. (IF: 2.071) (corresponding author, 4/61 in chemistry, applied).
31. Su, C.-Y.; Cheng, T.-J. R.; Lin, M.-I.; Wang, S.-Y.; Huang, W.-I.; Lin-Chu, S.-Y.; Chen, Y.-H.; Wu, C.-Y.; Lai, M.-C. M.; Cheng, W.-C.; Wu, Y.-T.; Tsai, M.-D.; Cheng Y.-S. E.*; Wong, C.-H.*, High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity. Proc. Natl. Acad. Sci. U.S.A. 2010, 107 (45), 19151-6. (IF: 9.432) (co-author; times cited: 2; 3/42 in multidisciplinary, science)
32. Shih, H.-W.; Chen, K.-T.; Chen, S.-K.; Huang, C.-Y.; Cheng, T.-J. R.; Ma, C.; Wong, C.-H.*; Cheng, W.-C.*, Combinatorial approach toward synthesis of small molecule libraries as bacterial transglycosylase inhibitors. Org. Biomol. Chem. 2010, 8 (11), 2586-2593. (IF: 3.762) (corresponding author, 10/55 in chemistry, organic)
33. Liu, C.-Y.; Guo, C.-W.; Chang, Y.-F.; Wang, J.-T.; Shih, H.-W.; Hsu, Y.-F.; Chen, C.-W.; Chen, S.-K.; Wang, Y.-C.; Cheng, T.-J. R.; Ma, C.; Wong, C.-H.; Fang, J.-M.*; Cheng, W.-C.*, Synthesis and evaluation of a new fluorescent transglycosylase substrate: Lipid II-based molecule possessing a dansyl-C20 polyprenyl moiety. Org. Lett. 2010, 12 (7), 1608-1611. (IF: 5.42) (corresponding author, 4/55 in chemistry, organic)
34. Cheng, T.-J. R.; Wu, Y.-T.; Yang, S.-T.; Lo, K.-H.; Chen, S.-K.; Chen, Y.-H.; Huang, W.-I.; Yuan, C.-H.; Guo, C.-W.; Huang, L.-Y.; Chen, K.-T.; Shih, H.-W.; Cheng, Y.-S. E.; Cheng, W.-C.; Wong, C.-H.*, High-throughput identification of antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) and the transglycosylase. Bioorg. Med. Chem. 2010, 18 (24), 8512-8529. (IF: 2.822) (co-author, 12/55 in chemistry, organic)
35. Chan, T.-H.; Chang, Y.-F.; Hsu, J.-J.; Cheng, W.-C.*, Straightforward synthesis of diverse 1-deoxyazapyranosides via stereocontrolled nucleophilic additions to six-membered cyclic nitrones. Eur. J. Org. Chem. 2010, 2010 (29), 5555-5559. (IF: 3.206) (corresponding author, 13/56 in chemistry, organic)
36. Tsou, E.-L.; Yeh, Y.-T.; Liang, P.-H.; Cheng, W.-C.*, A convenient approach toward the synthesis of enantiopure isomers of DMDP and ADMDP. Tetrahedron 2009, 65 (1), 93-100. (IF: 3.219, times cited: 24) (corresponding author, 16/55 in chemistry, organic)
37. Sung, M.-T.; Lai, Y.-T.; Huang, C.-Y.; Chou, L.-Y.; Shih, H.-W.; Cheng, W.-C.; Wong, C.-H.*; Ma, C.*, Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 2009, 106 (22), 8824-8829. (IF: 9.432, times cited: 20) (co-author, 3/42 in multidisciplinary, science)
38. Shih, H.-W.; Guo, C.-W.; Lo, K.-H.; Huang, M.-Y.; Cheng, W.-C.*, Solution-phase parallel synthesis of novel spirooxazolinoisoxazolines. J. Comb. Chem. 2009, 11 (2), 281-287. (IF: 3.45, times cited: 3) (corresponding author, 2/61 in chemistry, applied)
39. Tsou, E.-L.; Chen, S.-Y.; Yang, M.-H.; Wang, S.-C.; Cheng, T.-J. R.*; Cheng, W.-C.*, Synthesis and biological evaluation of a 2-aryl polyhydroxylated pyrrolidine alkaloid-based library. Bioorg. Med. Chem. 2008, 16 (24), 10198-10204.
40. (IF: 2.822, times cited: 10) (corresponding author, 12/55 in chemistry, organic)
41. Shih, H.-W.; Cheng, W.-C.*, Solution-phase parallel synthesis of highly diverse spiroisoxazolinohydantoins. Tetrahedron Lett. 2008, 49 (6), 1008-1011. (IF: 2.66, times cited: 10); (corresponding author, 21/55 in chemistry, organic)
42. Huang, C.-M.; Liu, R.-S.; Wu, T.-S.; Cheng, W.-C.*, Structural establishment of polygalatenosides A and B by total synthesis. Tetrahedron Lett. 2008, 49 (18), 2895-2898. (IF: 2.66, times cited: 3); (corresponding author, 21/55 in chemistry, organic)
43. Cheng, T.-J. R.; Sung, M.-T.; Liao, H.-Y.; Chang, Y.-F.; Chen, C.-W.; Huang, C.-Y.; Chou, L.-Y.; Wu, Y.-D.; Chen, Y.-H.; Cheng, Y.-S. E.; Wong, C.-H.*; Ma, C.*; Cheng, W.-C.*, Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics. Proc. Natl. Acad. Sci. U.S.A. 2008, 105 (2), 431-436. (IF: 9.432, time cited: 15); (corresponding author, 3/42 in multidisciplinary, science)
44. Chang, Y.-F.; Liu, C.-Y.; Guo, C.-W.; Wang, Y.-C.; Fang, J.-M.*; Cheng, W.-C.*, Solid-phase organic synthesis of polyisoprenoid alcohols with traceless sulfone linker. J. Org. Chem. 2008, 73 (18), 7197-7203. (IF: 4.219, times cited: 8); (corresponding author, 7/55 in chemistry, organic)
45. Chang, Y.-F.; Jiang, Y.-R.; Cheng, W.-C.*, Traceless sulfone linker cleavage triggered by ozonolysis: solid-phase synthesis of diverse α, β-unsaturated carbonyl compounds Tetrahedron Lett. 2008, 49 (3), 543-547. (IF: 2.66, times cited: 6); (corresponding author, 21/55 in chemistry, organic)
46. Liang, P.-H.; Cheng, W.-C.; Lee, Y.-L.; Yu, H.-P.; Wu, Y.-T.; Lin, Y.-L.; Wong, C.-H., Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: New structures for antivirals and osteoarthritis. ChemBioChem 2006, 7, 165-173. (co-author, 7/41 in chemistry, medicinal)
47. Sanna, M. G.; Wang, S.-K.; Gonzalez-Cabrera, P. J.; Don, A.; Marsolais, D.; Matheu, M. P.; Wei, S. H.; Parker, I.; Jo, E.; Cheng, W.-C.; Cahalan, M. D.; Wong, C.-H.; Rosen, H., Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat. Chem. Biol. 2006, 2, 434-441. (co-author)
48. Sawkar, A. R.; Adamski-Werner, S. L.; Cheng, W.-C.; Wong, C.-H.; Beutler, E.; Zimmer, K.-P.; Kelly, J. W., Gaucher Disease-Associated Glucocerebrosidases Show Mutation-Dependent Chemical Chaperoning Profiles. Chem. Biol. 2005, 12, 1235-1244. (co-author)
49. Best, M. D.; Brik, A.; Chapman, E.; Lee, L. V.; Cheng, W.-C.; Wong, C.-H., Rapid discovery of potent sulfotransferase inhibitors by diversity-oriented reaction in microplates followed by in situ screening. ChemBioChem 2004, 5, 811-819. (co-author)
50. Sawkar, A. R.; Cheng, W.-C.; Beutler, E.; Wong, C.-H.; Balch, W. E.; Kelly, J. W., Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease. Proc. Natl. Acad. Sci. U. S. A. 2002, 99, 15428-15433. (co-author)
51. Cheng, W.-C.; Wong, M.; Olmstead, M. M.; Kurth, M. J., Solid-Phase Synthesis of Novel Isoxazolocyclobutanones and Isoxazolinocyclobutenones. Org. Lett. 2002, 4, 741-744. (First author)
52. Cheng, W.-C.; Liu, Y.; Wong, M.; Olmstead, M. M.; Lam, K. S.; Kurth, M. J., Stereoselective Synthesis of Unnatural Spiroisoxazolinoproline-Based Amino Acids and Derivatives. J. Org. Chem. 2002, 67, 5673-5677. (First author)
53. Cheng, W.-C.; Lin, C.-C.; Kurth, M. J., Dimsyl anion in the monoalkylation of solid-phase alkyl sulfones. Tetrahedron Lett. 2002, 43, 2967-2970. (First author)
54. Cheng, W.-C.; Kurth, M. J., The Sulfone Linker in Solid-Phase Synthesis: Preparation of 3,5-Disubstituted Cyclopent-2-enones. J. Org. Chem. 2002, 67, 4387-4391. (First author)
55. Cheng, W.-C.; Kurth, M. J., The Zincke reaction. A review. Org. Prep. Proced. Int. 2002, 34, 585,587-608. (First author)
56. Cheng, W.-C.; Olmstead, M. M.; Kurth, M. J., Vinyl sulfones in solid-phase synthesis: preparation of 4,5,6,7-tetrahydroisoindole derivatives. J. Org. Chem. 2001, 66, 5528-5533. (First author)
57. Cheng, W.-C.; Halm, C.; Evarts, J. B.; Olmstead, M. M.; Kurth, M. J., Allylic Sulfones in Solid-Phase Synthesis: Preparation of Cyclobutylidenes. J. Org. Chem. 1999, 64, 8557-8562. (First author)
Invited talks and oral presentation
1. Department of Chemical Engineering, National Cheng Kung University, Taiwan, 2004,
2. Department of Chemistry, National Cheng Kung University, Taiwan, 2005
3. Department of Chemistry, National Tsing Hua University, Taiwan, 2006
4. Department of Applied Chemistry, National Defense University, Taiwan, 2006
5. The CSJ (Chemical society of Japan) Asian International Symposium, Japan, 2007.
6. Department of Chemistry, Tamkang University, Taiwan, 2007.
7. Department of Chemistry, National Chiayi University, Taiwan 2008
8. Pre-symposium of the 9th International Symposium on Organic Reactions-Workshop on Frontier Organic Synthesis and Glycoscience, National Tsing Hua University, Taiwan, 2008
9. Department of Chemistry, National Chung Hsing University, Taiwan, 2009
10. Department of Applied Chemistry, National Chiao Tung University, Taiwan, 2009.
11. Department of Chemistry, Chung Shan Medical University, Taiwan, 2009
12. The 7th International Symposium for Chinese Medicinal Chemists (ISCMC2010), Taiwan, 2010.
13. The 25th international symposium of glycosciences, Taiwan, 2010
14. The 2010 Mini-symposium on chemical biology, Taiwan, 2010
15. BIT's 1st Annual World Congress of Microbes-2011, Beijing, China
16. 2013- RIKEN-Academia Sinica Joint Conference, Taipei, Taiwan
17. The Joint Symposium of UC Davis and Academia Sinica Taiwan, USA, 2013
18. 5th AGCC, Khon Kaen, Thailand, 2013.
19. Canada-Asia glycoscience Symposium, Vancouver, Canada, 2014.
20. Glycobiology and Glycochemistry, New Taipei City, Taiwan, 2015
21. 2015 PST Medicinal Chemistry Symposium, Nantou, Taiwan, 2015.
22. RIKEN-Academia Sinica Joint Conference on Chemical Biology, Oct, 2015
23. Glycoscience Symposium, Academia Sinica, Taipei, Taiwan, Nov, 2015
24. The 10th International Conference on Cutting-Edge Organic Chemistry in Asia（ICCEOCA-10）& The 1st Advanced Research Network on Cutting-Edge Organic Chemistry in Asia（ARNCEOCA-1, Kaohsiung, Taiwan, Nov 2015
25. The international Chemical Congress of Pacific Basin Societies 2015, Hawaii, USA, Dec, 2015
26. Tenth International Symposium for Chinese Medicinal Chemistry, 10th ISCMC, Miaoli , Taiwan, 2016.
27. Bilateral symposium of GRC-Osaka Univ, Japan, 2016
28. The Joint Symposium of Peking Univ and Academia Sinica Taiwan, Taipei, 2016.
29. The 11th International Conference on Cutting-Edge Organic Chemistry in Asia / The 2nd Advanced Research Network on Cutting-Edge Organic Chemistry in Asia, Korea, 2016.
30. 8th AGCC Annual Conference (Asian Community of Glycoscience and Glycotechnology), Wuxi, China, 2016
31. Department of Medicinal and Applied Chemistry, Kaohsiung Medical Univ, Taiwan, 2017
32. Department of Chemistry, National Central University, Taiwan, 2017
33. Department of Entomology, National Taiwan University, Taiwan, 2017
34. 254th ACS National Meeting & Exposition, Washington, DC, US, 2017
35. Bilateral symposium of GRC-Osaka Univ, Taiwan, 2017
36. Department of Chemistry, Tamkang University, New Taipei City, Taiwan, 2017
37. 24th IUBMB CONGRESS & 15th FAOBMB CONGRESS, Seoul, 2018
38. The 10th Asian Community of Glycoscience and Glycotechnology, Tainan, Taiwan , 2018
39. Bilateral symposium of GRC-Osaka Univ, Japan, 2018
40. Bilateral symposium of GRC- University of the Philippines Manila’s , Philippine, 2018