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陳玉如教授(合聘)

陳玉如 教授教授近照

一、學歷:

美國愛荷華州立大學物理化學博士

二、經歷:
  • 代理所長(108年迄今-),
  • 81年國立台灣大學化學學士,
  • 86年美國愛荷華州立大學物理化學博士。
  • 86年美國Ames實驗室博士後研究員,
  • 87至88年國立清華大學博士後研究員,
  • 88年94年中央研究院化學研究所助研究員。

三、專業領域:

生物質譜法、蛋白質體學

四、連絡方式( Tel or e-mail):

   886-2-27898660  

  yjchen@chem.sinica.edu.tw

五、研究方向:

本實驗室團隊的研究興趣,主要是發展及利用各種質譜學方法,進行蛋白質體學的研究。目前,我們朝三個主要研究方向進行深入的探討:

‧利用電噴灑質譜法,結合化學交錯鍵結策略,研究蛋白質複合體的非共價鍵性交互作用,並藉此了解蛋白質複合體的可能聚合的方式與結構。
‧藉由比較蛋白質體學的技術,深入探討疾病的可能成因,進而開發可用於臨床檢測的生物標記分子。同時,我們亦投注心力於改良及開發新式的比較蛋白質體學技術。
‧發展高專一性、高靈敏度的奈米質譜法,可快速分離及檢測感興趣的蛋白質,並將此一技術應用於其他蛋白質體學研究。

六、期刊著作:

  • “Mechanistic Aspect of Co(HAPP)(TFA)2 in DNA Bulge-Specific Recognition” Chien-Chung Cheng*, Wei-Chun Huang-Fu, Kuo-Chan Hung, Po-Jui Chen, Wen Jwu Wang, and Yu-Ju Chen*, Nucleic Acid Res . 31 , 2227-2233 (2003).

  • “Quantitative proteomic analysis of metabolic regulation by copper ions in methylococcus capsulatus (Bath)”,Wei-Chun Kao, Yat-Ren Chen, Eugene C. Yi, Hookeun Lee, Qiang Tian, Keh-Ming Wu, Shih-Feng Tsai, Steve S. -F. Yu, Yu-Ju Chen, Ruedi Aebersold, and Sunney I. Chan, J. Biol. Chem. , 279 , 51554-51560 (2004).

  • “Identification of Acute Phase Proteins in Sera of Nude Mice Inoculated with Human Cancer Cells Using Proteomics Techniques” Hsueh-Fen Juan, Jenn-Han Chen*, Wei-Tse Hsu, Su-Ching Huang, Shui-Tein Chen, John Yi-Chung Lin, Yu-wang Chang, Chih-Yin Chiang, Li-Li Wen, De-Chuan Chan, Yao-Chi Liu, Yu-Ju Chen*, Proteomics , 4 , 2766-2775 (2004) (featured as cover story) .

  • “Plasma proteome of Severe Acute Respiratory Syndrome (SARS) analyzed by two-dimensional gel electrophoresis and mass spectrometry”, Jenn-Han Chen*, Yu-Wang Chang, Chen-Wen Yao, Tzong-Shi Chiueh, Su-Chin Huang, Ko-Yi Chien, An Chen, Feng-Yee Chang, Chi-Huey Wong, and Yu-Ju Chen*, Proc. Natl. Acad. Sci. USA., 101 , 17039-17044 (2004).

  • “Structural characterization of sialic acid synthase by electrospray mass spectrometry a tetrameric enzyme composed of dimeric dimers” Hsin-Hung Huang, Hsin-Kai Liao, Tzann-Shun Hwang, Yi-Han Lin, Chun-Hung Lin and Yu-Ju Chen*, J. Am. Soc. Mass Spectrom. 16, 324-332 (2005)

  • “Carbohydrate-Encapsulated Gold Nanoparticle for Rapid Target Protein Identification and Binding Epitope Mapping” Yu-Ju Chen*, Shu-Hua Chen, Yuh-Yih Chien, Yu-Wan Chang, Hsin-Kai Liao, Chih-Yang Chang, Mi-Dan Jan, Ken-Tseng Wang, and Chun-Cheng Lin*, ChemBioChem, 6 ,1169-1173

  • “Nanoprobe-Based Affinity Mass Spectrometry for Selected Protein Profiling in Human Plasma” Po-Hung Chou, Shu-Hua Chen, Hsin-Kai Liao, Po-Chiao Lin, Gour Rong Her, Alan Chuan-Ying Lai, Chun-Cheng Lin,* and Yu-Ju Chen,* Anal. Chem . 77 , 5990-5997 (2005)

  • “Determination of SMN1/SMN2 Gene Dosage by a Quantitative Genotyping Platform Combining Capillary Electrophoresis and MALDI-TOF Mass Spectrometry.” Hung-Yi Kao, Yi-Ning Su, Hsin-Kai Liao, Ming S. Liu, and Yu-Ju Chen, Clin. Chem. 52 , 361-369 (2006)

  • “Ethylene Glycol-Protected Magnetic Nanoparticles for Multiplexed Immunoassay in Human Plasma.” Po-Chiao Lin, Po-Hung Chou, Shu-Hua Chen, Hsin Kai Liao, Kai-Yi Wang, Yu-Ju Chen,* and Chun-Cheng Lin,* Small , 2 , 485-489 (2006)

七、 研討會論文

八、研究計畫:

九、其他:

十、教授課目: